Similac Pro Sensitive Vs All Enfamil Formulas: Full Comparison

You are currently viewing Similac Pro Sensitive Vs All Enfamil Formulas: Full Comparison

Similac Pro Sensitive is a lactose-reduced formula by 99% designed to help reduce gas, and fussiness due to lactose sensitivity made from milk protein isolate with an 18:82 whey to casein ratio. It’s palm oil-free and has two prebiotics (2′-FL HMO and FOS) to help the immune system. According to moms’ reviews, it’s good for fussiness and has good taste, but it can cause constipation and gas for some babies, also, it’s too foamy.

In this article, we will see a full comparison between Similac Pro Sensitive and all Enfamil formulas. Stay with me!

“When you buy something using my links, I may earn a small commission at no additional cost to you. This is a kind of support to me. This website doesn’t accept money for reviews. “

Similac Pro Sensitive vs Enfamil Neuropro Sensitive:

Similac Pro Sensitive vs Enfamil Neuropro Sensitive

Similac Pro Sensitive and Enfamil Neuropro Sensitive are both lactose-reduced formulas by 99% designed for babies who have fussiness and gassiness due to lactose sensitivity, as a protein source they use milk protein isolate with a different whey to casein ratio; Pro Sensitive has 18:82 while Neuropro Sensitive has 60:40. Furthermore, the latter add no sugar and has the MFGM feature whereas Similac Pro Sensitive doesn’t add palm oil in carbs sources.

Moreover, Neuropro Sensitive has the 2′-FL HMO prebiotic to help promote gut health. In contrast, Pro Sensitive has two prebiotics (2′-FL HMO and FOS).

In terms of nutrients, Neuropro Sensitive has more vitamins and minerals than Similac Pro Sensitive.

Enfamil Neuropro Sensitive has added a new feature called MFGM (milk fat globule membrane) extracted from whey protein-lipid concentrate which protects against some infectious diseases and promotes brain development whereas the new feature of Similac Pro Sensitive is OptiGro which is a blend of DHA, lutein, and vitamin E for the brain, cell, and eye development.

In terms of price, we can’t compare the two formulas because they haven’t the same sizes. However, buying the 29.8oz can of Pro Sensitive saves you more money because it costs 1.24$ /oz whereas Neuropro Sensitive has only a 19.5 oz can that costs 1.73$ /oz. Also, Pro Sensitive has a ready-to-feed form that costs 25.4 ¢/fl oz.

Moms Reviews of Pro Sensitive and Neuropro Sensitive:

Similac Pro SensitiveEnfamil Neuropro Sensitive
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
– Good for babies with
lactose sensitivity
– Good for reflux
– Good for gas
– Good taste
Negative
Reviews
May cause constipation
May cause gas
Too foamy
Doesn’t have a big size
Doesn’t have RTF
Expensive
Hard to find

Can you switch between Similac Pro Sensitive and Enfamil Neuropro Sensitive?

Yes, your baby can take Similac Pro Sensitive and Enfamil Neuropro Sensitive interchangeably in case you didn’t find your primary formula because they are of the same type (lactose-reduced) and have the same protein and carbohydrate sources and the same nutrient value your baby needs.

You can switch gradually or cold turkey, both ways are safe.

Most babies can take 1 to 2 weeks to get used to the new formula. Thus, don’t switch quickly and give your baby time on every formula he drinks so you can judge whether the formula is good or not.

This table shows a complete comparison between those two formulas. For a better view rotate your phone screen.

Similac Pro SensitiveEnfamil Neuropro Sensitive
Protein sourceMilk Protein Isolate70%  Milk Protein Isolate
30% whey protein-lipid concentrate
Whey to Casein Ratio18:8260:40
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
– 1% Lactose
– 99% Corn Syrup
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroMFGM
Prebiotics– 2′-FL HMO
Short-chain Fructooligosaccharides
2′-FL HMO
Generic Brands7 Generic brands7 Generic brands
Protein (g)2.1 /100 Cal2.2 /100 Cal
Fat (g)5.4 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.9 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal88 /100 Cal
Phosphorus (mg)56 /100 Cal59 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)30 /100 Cal33 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilSchizochytrium sp. oil
Size and Price29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
19.5 oz
33.77 $
1.73 /oz
Rating4.3 of 5.0
895 reviews
4.8 of 5.0
621 reviews
Ready-to-feedYesNo
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 19.5 oz HERE
Overall Note7.5/107.5/10
Similac Pro Sensitive vs Enfamil Neuropro Sensitive

Similac Pro Sensitive vs Enfamil Neuropro Gentlease:

Similac Pro Sensitive vs Enfamil Neuropro Gentlease

The difference between Similac Pro sensitive and Enfamil Neuropro Gentlease is that the latter has a partially hydrolyzed protein plus a whey protein concentrate (source of MFGM) to help reduce crying, spit-up, gas, and fussiness for babies with intact milk protein and lactose allergy, also, it’s lactose-reduced by 80% and sugar-free whereas Pro Sensitive has an intact cow’s milk protein (milk protein isolate) and uses only 1% of lactose among carbohydrate sources the other sources are from corn syrup and sugar.

Similac Pro Sensitive has a whey to casein ratio of 18:82. In contrast, Neuropro Sensitive has 60:40. Thus, the latter has the closest ratio to breastmilk which is between 70% to 30% and 80% to 20% in early lactation and 50% to 50% in late lactation.

I did a full comparison between Enfamil Gentlease and Similac Pro Sensitive if you want to check.

The body quickly digests the whey protein whereas casein stays in the stomach as curds and takes more time to be digested.

A partially hydrolyzed formula is a formula that chopped the protein a little bit in size to resemble that found in breast milk and not to be detected by the immune system. Sometimes, the latter can detect this protein and elicit allergic responses, that’s why there are extensively hydrolyzed formulas (hypoallergenic formulas) like Nutramigen, Alimentum, and Gerber Extensive HA that have a protein size of 3 KiloDalton while the normal size range is 14 to 67 KiloDalton.

In case the immune system reacts to hypoallergenic formulas, the only solution is the amino-acid formulas like Alfamino and Puramino they have a protein size of 1KiloDalton.

Image source: Nestle Health Science

In terms of price, Similac Pro Sensitive is available in powder and RTF forms and they are cheaper than those of Enfamil Neuropro Gentlease.

Moms Reviews of Pro Sensitive and Neuropro Gentlease:

Similac Pro SensitiveEnfamil Neuropro Gentlease
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
– Good for fussiness
– Good for gas
– Good for reflux
– RTF is cheaper
Negative
Reviews
May cause constipation
May cause gas
Too foamy
Taste not so pleasant
doesn’t mix well

The table below shows a full comparison between those two formulas. For a better view rotate your phone screen.

Similac Pro SensitiveEnfamil Neuropro Gentlease
Protein sourceMilk Protein IsolatePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Whey to Casein Ratio18:8260:40
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
80 % Corn syrup solids
20 % Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroMFGM
Prebiotics– 2′-FL HMO
Short-chain Fructooligosaccharides
2′-FL HMO
Generic Brands7 Generic brands6 Generic brands
Protein (g)2.1 /100 Cal2.3 /100 Cal
Fat (g)5.4 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.9 /100 Cal10.8 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal82 /100 Cal
Phosphorus (mg)56 /100 Cal46 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)30 /100 Cal40 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilSchizochytrium sp. oil
Size and Price29.8 oz
36.96 $
1.24 /oz


32 fl oz
8.12$
25.4 ¢/fl oz
19.5 oz
27.98 $
1.44/oz

27.4 oz
38.36 $
1.40 /oz

35.2 oz
47.46 $
1.35 /oz

32 Fl Oz
9.64$
30.1 ¢/fl oz
Rating4.3 of 5.0
895 reviews
4.6 of 5
3370 reviews
Ready-to-feedYesYes
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 19.5 oz HERE

Buy 27.4 oz HERE

Buy 35.2 oz HERE

Buy Ready-to-use
Overall Note7.5/107.5/10
Similac Pro Sensitive vs Enfamil Neuropro Gentlease

Similac Pro Sensitive vs Enfamil Reguline:

Similac Pro Sensitive vs Enfamil Reguline

The difference between Similac Pro sensitive and Enfamil Reguline is that the latter is a partially hydrolyzed formula designed for babies who have stool issues (like hard stools..). Also, it’s lactose-reduced by 50% and sugar-free. In contrast, Similac Pro Sensitive has an intact cow’s milk protein (milk protein isolate) and contains only 1% of lactose among carbohydrate sources the other sources are corn syrup and sugar.

Related: What Does a Combo-Fed Baby Poop Looks Like?

Enfamil Reguline has no extra features but it has two prebiotics (GOS and PDX) to help gut health whereas Pro Sensitive has the OptiGro feature explained above and also has two prebiotics (2′-FL HMO and FOS). Also, it has no palm oil to prevent calcium and fat malabsorption.

Enfamil Reguline has a low iron level (1.5 mg/100 Cal) to help promote soft stools compared to Similac Pro Sensitive (1.8 mg/100 Cal).

Furthermore, Similac Pro Sensitive has a ready-to-feed form while Reguline hasn’t.

Moms Reviews of Pro Sensitive and Reguline:

Similac Pro SensitiveEnfamil Reguline
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
– Great for constipation
– Soft stools
– Good taste
– Easy to mix
Negative
Reviews
May cause constipation
May cause gas
Too foamy
Expensive
Doesn’t have big sizes

The table below shows a full comparison between those two formulas. For a better view rotate your phone screen.

Similac Pro SensitiveEnfamil Reguline
Protein sourceMilk Protein IsolatePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Whey to Casein Ratio18:8260:40
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
50 % Corn syrup solids
50 % Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGro
Prebiotics– 2′-FL HMO
– Short-chain Fructooligosaccharides
Galactooligosaccharides
polydextrose
Generic Brands7 Generic brands6 Generic brands
Protein (g)2.1 /100 Cal2.3 /100 Cal
Fat (g)5.4 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.9 /100 Cal11.1 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal6 /100 Cal
Calcium (mg)84 /100 Cal82 /100 Cal
Phosphorus (mg)56 /100 Cal46 /100 Cal
Iron (mg)1.8 /100 Cal1.5 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)30 /100 Cal36 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
12.4 oz
18.72 $
1.51 /oz

19.5 oz
29.98 $
1.54/oz
Rating4.3 of 5.0
895 reviews
4.8 of 5.0
1020 reviews
Ready-to-feedYesNo
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 12.4 oz HERE

Buy 19.5 oz HERE
Overall Note7.5/108/10
Similac Pro Sensitive vs Enfamil Reguline

Similac Pro Sensitive vs Enfamil Infant:

Similac Pro Sensitive vs Enfamil Infant

The difference between Similac Pro Sensitive and Enfamil Infant is that the latter is a standard milk-based formula designed for babies with no sensitivity issues made from nonfat milk plus whey protein concentrate as protein sources and 100% lactose as a carbohydrate source. In contrast, Pro sensitive is a formula for babies with lactose sensitivity made from milk protein isolate as a protein source and 1% lactose plus corn syrup and sugar as carbohydrate sources.

In terms of price, Enfamil Infant is cheaper in the powder form whereas Pro Sensitive is cheaper in the ready-to-use form.

Moms Reviews of Pro Sensitive and Enfamil Infant:

Similac Pro SensitiveEnfamil Infant
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
Good taste
Easy to mix
Easy to digest
Available in RTF
Negative
Reviews
May cause constipation
May cause gas
Too foamy
has palm oil

Can you switch between Similac Pro Sensitive and Enfamil Infant?

Switching from regular formula to a sensitive formula is safe, thus you can switch from Enfamil Infant to Pro Sensitive in case your baby has bad reactions to the first formula because Pro Sensitive is lactose-reduced by 99% so it will reduce negative reactions due to lactose sensitivity.

In contrast, switching from Pro Sensitive to Enfamil Infant is not recommended if the baby still has lactose intolerance in this case you may switch to another lactose-reduced (like Neuropro Sensitive and Similac Total Comfort/ Pro Total Comfort) or a lactose-free formula (like Nutramigen, Alimentum, and Gerber Extensive HA).

There are 4 alternatives to Similac Sensitive in the Similac brand, I did a complete comparison between Similac Pro Sensitive vs all Similac formulas.

However, if the baby has recovered from lactose sensitivity, then he can take both formulas interchangeably.

The table below shows a complete comparison between Pro Sensitive and Enfamil Infant. For a better view rotate your phone screen.

Similac Pro SensitiveEnfamil Infant
Protein sourceMilk Protein IsolateNonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio18:8260:40
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGro
Prebiotics– 2′-FL HMO
– Short-chain Fructooligosaccharides
– Galactooligosaccharides
– Polydextrose
Generic Brands7 Generic brands9 Generic brands
Protein (g)2.1 /100 Cal2 /100 Cal
Fat (g)5.4 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.9 /100 Cal11.3 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal6 /100 Cal
Calcium (mg)84 /100 Cal78 /100 Cal
Phosphorus (mg)56 /100 Cal43 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)30 /100 Cal27 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
12.5 oz
17.26 $
1.38 /oz

21.1 oz
25.27 $
1.20 /oz

29.4 oz
35.83 $
1.22 /oz


32 fl oz
8.98$
28.1 ¢/fl oz
Rating4.3 of 5.0
895 reviews
4.8 of 5.0
3133 reviews
Ready-to-feedYesYes
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 12.5 oz HERE

Buy 21.1 oz HERE

Buy 29.4 oz HERE

Buy Ready-to-use
Overall Note7.5/107/10
Similac Pro Sensitive vs Enfamil Infant

Similac Pro Sensitive vs Enfamil Enspire:

Similac Pro Sensitive vs Enfamil Enspire

The difference between Enfamil Enspire and Similac Pro Sensitive is that the first is a regular milk-based formula designed for babies with no health issues, it has as protein sources nonfat milk plus whey protein concentrate, and 100% lactose as a carbohydrate source whereas Pro sensitive is a formula designed to help reduce gas and fussiness due lactose sensitivity made from milk protein isolate as a protein source and 1% lactose plus corn syrup and sugar as carbohydrate sources.

Enfamil Enpsire has added three features; Omega 3 DHA, Lactoferrin (which is a protein source and its role is to protect against viruses and infections. Also, it helps regulate iron absorption by the body), and MFGM (milk fat globule membrane) extracted from whey protein-lipid concentrate, it protects against some infectious diseases and helps promote brain development.

With these features, Enfamil Enspire is considered the closest formula to breast milk in the Enfamil brand and that explains the high price (1.9$ /oz). In contrast, Pro Sensitive has a reasonable price (1.24$ /oz).

Every brand wants to promote that their formulas are the closest to breast milk by adding some features and prebiotics so they you convince to stick with that specific brand. In fact, the lack of these features and prebiotics hasn’t an impact on your baby’s health. The most important thing to consider in a formula is the protein, carbohydrate sources, and nutrient value.

Moms Reviews of Pro Sensitive and Enspire:

Similac Pro SensitiveEnfamil Enspire
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
Good taste
Easy to mix
Easy to digest
Negative
Reviews
May cause constipation
May cause gas
Too foamy
Doesn’t have a small size
Doesn’t have RTF
Overpriced

Can you switch between Similac Pro Sensitive and Enfamil Enspire?

Switching from Enfamil Enspire to Pro Sensitive is safe because the safe switching is being from regular formula to a more sensitive one. In contrast, switching from Pro Sensitive to Enfamil Enspire is not recommended if the baby still has lactose intolerance in this case you may switch to another lactose-reduced or lactose-free formula.

However, if your baby hasn’t an allergy to lactose, he can take those formulas interchangeably.

The table below shows a complete comparison between Pro Sensitive and Enfamil Enspire. For a better view rotate your phone screen.

Similac Pro SensitiveEnfamil Enspire
Protein sourceMilk Protein IsolateNonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio18:8260:40
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOmega 3 DHA
Lactoferrin
MFGM
Prebiotics– 2′-FL HMO
– Short-chain Fructooligosaccharides
– Galactooligosaccharides
– Polydextrose
Generic Brands7 Generic brands9 Generic brands
Protein (g)2.1 /100 Cal2.1 /100 Cal
Fat (g)5.4 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.9 /100 Cal11.3 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal78 /100 Cal
Phosphorus (mg)56 /100 Cal43 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)30 /100 Cal27 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
20.5 oz
39.98 $
1.95 /oz

30 oz
56.97 $
1.90 /oz
Rating4.3 of 5.0
895 reviews
4.8 of 5.0
1693 reviews
Ready-to-feedYesNo
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 20.5 oz HERE

Buy 30 oz HERE
Overall Note7.5/107/10
Similac Pro Sensitive vs Enfamil Enspire

Final Thoughts:

The best alternative to Similac Pro Sensitive in the Enfamil brand is Enfamil Neuropro Sensitive because they are lactose-reduced by 99% and have the same protein source (milk protein isolate). Thus, they help reduce gas and fussiness due to lactose sensitivity.

In terms of price, Similac Pro Sensitive is cheaper than Enfamil Neuropro Sensitive and has a ready-to-feed form.

Enfamil Neuropro Gentlease could be also an alternative to Pro Sensitive although it has more lactose (20% lactose). However, we can’t judge until the baby tries it.

Credit:

Vs Vectors by Vecteezy

Leave a Reply