Similac 360 Total Care Vs Gerber Good Start Gentle: Full Comparison

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Key Differences?

Similac 360 Total Care and Gerber Good Start Gentle are both infant formulas designed for healthy babies without specific health issues. However, they differ in several key aspects:

Firstly, in terms of protein composition, Similac 360 Total Care has a whey to casein ratio of 48:52, while Gerber Good Start Gentle has a ratio of 70:30. This indicates that Similac may provide a more balanced blend of proteins, which could be advantageous for some babies.

Secondly, Similac 360 Total Care contains 5 HMO prebiotics, whereas Gerber Good Start Gentle contains only 1 HMO prebiotic. HMOs are essential for gut health and immunity. Additionally, while Similac 360 Total Care does not contain probiotics, Gerber Good Start Gentle does, potentially offering added digestive support for babies.

Another notable difference is the use of palm oil: Similac 360 Total Care does not include palm oil, while Gerber Good Start Gentle does. Lastly, there is a price discrepancy between the two formulas, with Similac 360 Total Care being more expensive than Gerber Good Start Gentle.

The Best One?

Choosing the best formula depends on various factors, including your baby’s specific needs, preferences, and any dietary considerations they may have. Based on the information provided:

  1. Similac 360 Total Care:
    • Contains 5 HMO prebiotics, which can support gut health.
    • No Palm Oil, which can be a preference for some parents.
    • Available in multiple sizes and ready-to-feed forms for convenience.
    • Higher fat content, which can be beneficial for some babies.
    • Fortified with minerals for overall nutrition.
  2. Gerber Good Start Gentle:
    • Contains probiotics (B. lactis), which can also support gut health.
    • Cheaper than Similac 360 Total Care, which can be a factor for some families.
    • Higher protein and carbohydrate content, potentially suitable for babies with higher energy needs.
    • Contains more vitamins, which are essential for overall development.

Considering these factors, if your baby doesn’t have any specific dietary requirements or sensitivities, both formulas can be suitable options. If gut health is a primary concern, Similac 360 Total Care may be preferred due to its prebiotic content. However, if cost is a significant factor or if your baby needs higher protein and carbohydrate intake, Gerber Good Start Gentle could be the better choice. Always consult with your pediatrician before making any changes to your baby’s formula.

Ingredients Comparison:

When comparing Similac 360 Total Care and Gerber Good Start Gentle infant formulas in terms of ingredients, several distinctions emerge. Both formulas are suitable for babies without specific health issues, catering to an age range of 0-12 months and using a protein base of nonfat milk and whey protein concentrate. However, notable differences arise in their formulations:

Whey to Casein Ratio:

Similac 360 Total Care exhibits a whey to casein ratio of 48:52, indicating a balanced blend of these proteins. In contrast, Gerber Good Start Gentle leans towards a higher whey content with a ratio of 70:30. This variance is significant as whey protein tends to be quicker for infants to digest compared to casein, influencing gastrointestinal comfort and nutrient absorption.

Fat Source:

The fat composition in both formulas differs slightly. Similac 360 Total Care incorporates a mix of high oleic safflower oil, soy oil, and coconut oil, omitting palm oil from its ingredients. On the other hand, Gerber Good Start Gentle includes palm oil alongside similar oils. The inclusion or exclusion of palm oil can impact the fatty acid profile and may have implications for digestion and nutrient absorption.

Extra Features:

Similac 360 Total Care sets itself apart by integrating a blend of DHA, lutein, and vitamin E into its formulation. These additional nutrients offer potential benefits for brain and eye development as well as overall immune support. Conversely, Gerber Good Start Gentle introduces B. lactis probiotic, which contributes to a healthy gut microbiome, fostering digestive well-being in infants.


Both formulas feature 2′-FL HMO as a prebiotic, known for its role in supporting gut health and immune function. However, Similac 360 Total Care extends its prebiotic profile by incorporating additional prebiotics such as Lacto-N-Tetraose, 3-Fucosyllactose, 6′-Sialyllactose, and 3′-Sialyllactose. This comprehensive prebiotic blend provides broader support for digestive health and immune function compared to Gerber’s formulation.

2′-Fucosyllactose (2′-FL) is a type of human milk oligosaccharide (HMO) prebiotic found naturally in breast milk. It plays a crucial role in promoting the growth of beneficial bacteria, particularly Bifidobacteria, in the infant gut microbiome. These beneficial bacteria help to support a healthy digestive system and contribute to overall immune function. Furthermore, 2′-FL has been associated with various health benefits, including reduced risk of infections, improved gut barrier function, and modulation of the immune response.


While Similac 360 Total Care does not include probiotics, Gerber Good Start Gentle integrates B. lactis probiotic into its formula. Probiotics are known to promote a healthy balance of gut bacteria, potentially reducing digestive discomfort and enhancing immune function in infants.

Bifidobacterium lactis (B. lactis) is a probiotic bacterium commonly found in the human gut microbiome and often included in infant formulas for its potential health benefits. As a probiotic, B. lactis has been studied extensively for its role in promoting digestive health and supporting the immune system. It is known to help maintain a balanced gut flora, which can aid in alleviating symptoms of digestive discomfort such as gas, bloating, and constipation in infants.

Nutrients Profile:


Gerber Good Start Gentle has a slightly higher protein 2.1g and carbohydrate content at 11.4g compared to Similac 360 Total Care’s 10.5g whereas this last has a higher fat content at 5.6g compared to Good Start Gentle’s 5.1g.


In terms of vitamins, Gerber Good Start Gentle has a higher level of Vitamin D (Essential for calcium absorption and bone development), Vitamin E (Acts as an antioxidant, supporting immune function and skin health), Vitamin B6 (Plays a role in brain development and function), Vitamin B12 (Necessary for DNA synthesis and nervous system function), and Vitamin C (Supports immune function and aids in iron absorption).

In contrast, 360 Total Care is fortified with high levels of Vitamin B2 (Supports energy metabolism and tissue repair) and Inositol (Important for brain development and nerve function).


In terms of minerals, Gerber Good Start Gentle contains higher levels of Magnesium (supports muscle and nerve function), Zinc (essential for immune function and growth), Manganese (supports bone formation and metabolism), and Selenium (acts as an antioxidant and supports thyroid function), Sodium, and Potassium.

Conversely, Similac 360 Total Care provides higher levels of Calcium (essential for bone and teeth development), Phosphorus (crucial for bone health), Iron (crucial for cognitive development and oxygen transport), Copper (essential for the production of red blood cells), Iodine (important for thyroid function). Both formulas contain equal amounts of Chloride.

Size and Price Comparison:

Price Variation Across Sizes: Both brands offer various sizes of their formulas, catering to different consumer needs and usage patterns. The prices per ounce vary across these sizes, with larger sizes generally offering a lower cost per unit compared to smaller sizes.

Comparison of Cost per Unit: When comparing the cost per ounce or fluid ounce, Gerber Good Start Gentle tends to have a lower price per unit in most cases. For example, in the 12.7 oz and 27 oz sizes, Good Start Gentle is notably cheaper per ounce compared to Similac 360 Total Care.

Ready to Feed: While Gerber Good Start Gentle may have a lower cost per unit in certain sizes, it’s essential to note that it is not available in the ready-to-feed form whereas 360 Total Care offers three forms (2fl oz, 8 fl oz, and 32 l oz) which are perfect for traveling and night feeding.

Consumer Ratings: Both formulas receive high ratings from consumers, with identical scores of 4.8 out of 5.0. This suggests that both brands are well-liked and trusted by parents, indicating comparable quality and effectiveness.

Where to Buy?

Buy 12.7 ozBuy 20.6 oz
Buy 27 ozBuy 30.8 oz
Buy 2-fl-oz
Buy 8-fl-oz
Buy 32-fl-oz

Alternatives to Similac 360 Total Care:

1. Enfamil NeuroPro:

Enfamil NeuroPro is another option similar to Similac 360 Total Care. It focuses on brain development in babies and contains nutrients like MFGM and DHA, which are important for brain growth and eye development. It’s suitable for babies from birth to 12 months and aims to provide similar nutrition to breast milk. Read Similac 360 Total Care Vs Enfamil Neuropro.

2. Enfamil Enspire Optimum:

Enfamil Enspire Optimum is another good choice for babies. It aims to give babies all the nutrition they need and contains ingredients like lactoferrin and MFGM to help with immune support and brain development, similar to breast milk. It also includes DHA and choline for brain growth. Read Enfamil Enspire Optimum Vs Similac 360 Total Care.

3. Similac Pro Advance:

Similac Pro Advance is a part of the Similac family and is similar to Similac 360 Total Care. It helps support babies’ immune systems and contains DHA, lutein, and vitamin E for brain and eye development. Read Similac Pro Advance vs Similac 360 Total Care.

4. HiPP Combiotic:

HiPP Combiotic is an organic formula option for Similac 360 Total Care. It’s made with organic ingredients and includes important nutrients like prebiotics and omega-3 and omega-6 fatty acids for babies’ growth. It’s suitable for babies from birth onwards and is a good choice for parents looking for organic formula options.

Alternatives to Gerber Good Start Gentle:

When considering alternatives to Gerber Good Start Gentle formulas, several options stand out in the market, each with its unique blend of nutrients and benefits:

1. Enfamil Neuropro:

Enfamil Neuropro is renowned for its focus on brain-building nutrition, much like Gerber Good Start Gentle. It contains MFGM (Milk Fat Globule Membrane) and DHA, key components known to support cognitive development. This formula is designed to mimic the structure of breast milk closely, making it an excellent option for parents seeking a gentle alternative.

2. Enfamil Enspire Optimum:

Enfamil Enspire Optimum is another notable alternative, boasting a unique blend of nutrients, including MFGM and lactoferrin, which are found in breast milk. This formula aims to support immune health and brain development, aligning closely with the goals of Gerber Good Start Gentle.

3. Enfamil Neuropro Care:

Enfamil Neuropro Care offers specialized nutrition for babies with specific needs, such as those born prematurely or with medical concerns. It contains essential nutrients like DHA and choline to support brain development, making it a reliable alternative for parents seeking a formula that caters to their baby’s unique requirements.

4. Enfamil Infant:

Enfamil Infant formula provides a balanced blend of nutrients necessary for healthy growth and development. While it may not contain specialized ingredients like MFGM, it offers complete nutrition for infants, making it a suitable alternative for parents looking for a reliable and well-rounded formula. Read Enfamil Infant Vs Gerber Good Start Gentle.

5. Similac Pro-Advance:

Similac Pro-Advance is a widely recognized formula known for its blend of OptiGRO™, a unique mix of DHA, lutein, and vitamin E, which supports brain and eye development. While it differs slightly from Gerber Good Start Gentle in terms of formulation, it remains a popular choice among parents seeking a trusted alternative.

4. HiPP Combiotic:

HiPP Combiotic is an organic formula option. It’s made with organic ingredients and includes important nutrients like prebiotics and omega-3 and omega-6 fatty acids for babies’ growth. It’s suitable for babies from birth onwards and is a good choice for parents looking for organic formula options. Read HiPP Combiotic VS Gerber Good Start Gentle.


In conclusion, the comparison between Similac 360 Total Care and Gerber Good Start Gentle reveals two commendable infant formulas, each with its distinct advantages. Similac 360 Total Care boasts prebiotics and no palm oil, promoting gut health and addressing potential dietary concerns. On the other hand, Gerber Good Start Gentle offers probiotics and a more affordable option, alongside higher protein and vitamin content. The ultimate choice depends on individual preferences, budget considerations, and specific nutritional needs of the infant. Consulting with healthcare professionals remains paramount in ensuring the optimal choice for the well-being of the baby.

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