Enfamil Enspire Optimum Vs Similac 360 Total Care: Full Comparison

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Key Differences:

Enfamil Enspire Optimum and Similac 360 Total Care are both standard milk-based formulas for babies without specific health issues. Both formulas aim to support immune system function, brain development, and digestive health, but there are key differences that lie in their extra features, nutrients, and price:

Enfamil Enspire Optimum includes a premium immune blend comprising MFGM, Lactoferrin, and HuMO6, along with 2 HMO prebiotics. Notably, it contains palm oil and is priced between $1.83 to $2.29 per ounce. On the other hand, Similac 360 Total Care, also designed for healthy babies in the same age range, features a blend of DHA, lutein, and vitamin E, along with 5 HMO prebiotics. A significant difference is that Similac 360 Total Care does not contain palm oil and is priced at a slightly lower range, ranging from $1.62 to $1.72 per ounce.

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The Best One?

Choosing the best formula depends on various factors, including the specific needs and preferences of the baby, as well as any potential concerns or priorities for the parents. Here’s a breakdown of the information you provided for Enfamil Enspire Optimum and Similac 360 Total Care:

Extra Features:

Enfamil Enspire Optimum contains specific components such as MFGM (Milk Fat Globule Membrane), Lactoferrin, and HuMO6 (Premium Immune Blend), in addition to 2 HMO Prebiotics. These elements are designed to support immune system development, brain function, and digestive health. If you prioritize these specific components, Enfamil Enspire Optimum might be a suitable choice.

Palm Oil:

Enfamil Enspire Optimum contains palm oil, while Similac 360 Total Care does not. Some parents prefer formulas without palm oil due to concerns about its impact on digestion and nutrient absorption. If this is a priority for you, 360 Total Care might be the preferred option.


Enspire Optimum offers a high mineral content compared to 360 Total Care, so if you prioritize this aspect, then choose Enspire Optimum.


Comparing the prices per ounce for both Enfamil Enspire Optimum and Similac 360 Total Care, we find that the latter is cheaper, thus it will be the best choice if your budget is limited.

Ready to Feed:

Similac 360 Total Care offers multiple ready-to-feed sizes, providing convenience for parents with busy lifestyles or those who prioritize ease of use. If this is a crucial factor for you, then choose this formula.

After carefully reviewing the details of both formulas, our recommendation leans towards Similac 360 Total Care because of its 5 HMO prebiotics, multiple ready to feed forms, and an affordable price.

Mom’s Reviews Comparison:

In the realm of maternal reviews, Enfamil Enspire Optimum and Similac 360 Total Care elicit varying sentiments based on user experiences:

Positive Reviews: Enfamil Enspire Optimum receives praise for being considered the closest to breast milk, thanks to its added Lactoferrin, with mothers noting a smooth transition from breastfeeding. Many highlight that their babies experienced no digestion problems, showcasing the formula’s gentle nature on the infant’s stomach. Additionally, positive reviews emphasize noticeable improvements in baby growth and developmental milestones, reinforcing the formula’s efficacy.

Negative Reviews: Some mothers express dissatisfaction with the cost, deeming the formula as “overpriced.” Complaints about an unpleasant smell or taste are raised, which may contribute to a less enjoyable feeding experience for both mothers and babies. A few users report challenges in dissolving the formula adequately, potentially leading to concerns regarding ease of preparation.

Positive Reviews: Similac 360 Total Care garners positive feedback for its good taste, making it more palatable for babies. Mothers appreciate the formula’s ready-to-feed bottles (2 fl oz and 8 fl oz), for being easy to travel with and easy to use. The formula shows good results in addressing gas issues, with many mothers reporting it as gentle on their baby’s stomach.

Negative Reviews: Some mothers report instances of their babies experiencing spit-up after consuming Similac 360 Total Care. Concerns about dark or unusual stool colors are mentioned, raising potential worries among parents. Additionally, a few users express difficulties in finding the product in physical stores, suggesting potential availability challenges.

Ingredients Comparison:

Age Range (0-12 months):

Both formulas are explicitly designed to meet the nutritional needs of infants aged 0-12 months. This crucial developmental stage necessitates specialized nutrition to support growth, cognitive development, and overall well-being.

Protein Source:

Enfamil Enspire Optimum: The protein composition is carefully calibrated with 55% nonfat milk, 1% lactoferrin, and 44% whey protein concentrate. This blend, with a whey-to-casein ratio of 65:35, mirrors the protein profile of breast milk, emphasizing the importance of whey for easy digestion.

Similac 360 Total Care: Utilizes a combination of nonfat milk and whey protein concentrate, with a slightly different whey to casein ratio of 48:52. The balanced protein profile ensures a comprehensive amino acid profile for optimal growth and development.

Carbohydrate Source:

Both formulas Solely relies on 100% lactose as the carbohydrate source. Lactose is the predominant carbohydrate in breast milk, providing a natural and easily digestible source of energy.

Fat Source:

Enfamil Enspire Optimum Incorporates a diverse blend of fats, including palm oil, high oleic sunflower oil, soy oil, and coconut oil. This combination ensures a comprehensive array of essential fatty acids for brain development whereas Similac 360 Total Care doesn’t include palm oil which is a factor to consider for parents who don’t love palm oil.

DHA/ARA Source:

Enfamil Enspire Optimum: Sources DHA from Schizochytrium sp. oil and ARA from Mortierella alpina oil. These omega-3 and omega-6 fatty acids are critical for brain and visual development.

Similac 360 Total Care: Sources DHA from Crypthecodinium cohnii oil and ARA from Mortierella alpina oil, emphasizing their roles in cognitive and visual development, respectively.

Extra Features:

Enfamil Enspire Optimum: Stands out with additional features like MFGM, lactoferrin, and HuMO6 (Premium Immune Blend). These elements contribute to immune support and overall nutritional richness.

MFGM (Milk Fat Globule Membrane) is a complex structure present in breast milk that encapsulates fat globules. It contains various bioactive components, including lipids and proteins, believed to support brain development, cognitive function, and immune health.

Lactoferrin is a protein with antimicrobial properties that helps regulate iron absorption. In infant formulas, it is often added to support the immune system and contribute to overall health. Enfamil Enspire Optimum is the only formula that has this component until now.

HuMO6 is a blend of 2′-FL (2′-Fucosyllactose) and LNnT (Lacto-N-neotetraose) Human Milk Oligosaccharides. Although not directly derived from human milk, these components replicate the composition of breast milk. In addition to these two prebiotics, it includes also essential nutrients such as Vitamin C, Vitamin E, Selenium, and Zinc. Together, these constituents work to support infant immune health, enhance gut well-being, and contribute to overall developmental benefits, mirroring the advantages of breast milk for formula-fed infants.

Similac 360 Total Care: incorporates a combination of DHA (docosahexaenoic acid), lutein, and vitamin E. These components play crucial roles in supporting cognitive development (DHA), eye health (lutein), and antioxidant protection (vitamin E).


Enfamil Enspire Optimum Contains 2 HMO prebiotics in the form of 2′-FL HMO and Lacto-N-neotetraose whereas Similac 360 Total Care adds three more HMO prebiotics, 3-Fucosyllactose, 6′-Sialyllactose, and 3′-Sialyllactose.

2′-FL HMO (2′-Fucosyllactose) is a type of human milk oligosaccharide (HMO), a complex sugar found in breast milk. It acts as a prebiotic, promoting the growth of beneficial bacteria in the infant’s gut and supporting a healthy microbiome.


Both Formulas are GMO-Free, ensuring that the ingredients used in the formula have not been genetically modified.

Nutrients Comparison:


Protein Content: Enfamil Enspire Optimum has a slightly higher protein content, which may be a factor for parents looking to ensure optimal growth for their infants.

Fat Composition: Both formulas provide a comparable amount of fat, 360 Total Care is slightly higher, emphasizing the importance of essential fatty acids for brain and visual development.

Carbohydrate Levels: Enfamil Enspire Optimum has a marginally higher carbohydrate content, offering additional energy for the infant’s growth and development.


There is a notable difference in terms of vitamin levels between the two formulas, Enfamil Enspire Optimum has higher levels of Vitamin C, D, E, K, and B12 as well as of Folic Acid and Pantothenic Acid than 360 Total Care while the latter has higher levels of Vitamin B1, B2, Niacin, and Biotin.

here’s a brief overview of the roles of the mentioned vitamins:

Vitamin C: Essential for collagen synthesis, antioxidant defense, immune function, and iron absorption.

Vitamin D: Promotes calcium absorption, supports bone health, and plays a role in immune system function.

Vitamin E: Acts as a potent antioxidant, supporting cell protection and immune function.

Vitamin K: Crucial for blood clotting, bone health, and cardiovascular support.

Vitamin B12: Essential for red blood cell formation, nervous system maintenance, and cognitive function.

Folic Acid (Vitamin B9): Vital for DNA synthesis, cell division, and prevention of neural tube defects during pregnancy.

Pantothenic Acid (Vitamin B5): Functions in metabolic pathways, aids in energy metabolism, and contributes to skin health.

Vitamin B1 (Thiamin): Converts carbohydrates into energy, supports nerve function, and is essential for amino acid metabolism.

Vitamin B2 (Riboflavin): Aids in energy production from fats, carbohydrates, and proteins, maintaining healthy skin, eyes, and nerves.

Niacin (Vitamin B3): Essential for energy metabolism, supports skin, nerves, and digestion, and plays a role in cholesterol regulation.

Biotin (Vitamin B7): Metabolizes fats, carbs, and proteins, supports healthy skin, hair, and nails, and aids in glucose production during fasting.


In the realm of essential minerals, Enfamil Enspire Optimum and Similac 360 Total Care exhibit nuanced distinctions. Enfamil Enspire Optimum edges higher in Magnesium content (crucial for muscle and nerve function), Zinc content (impacts immune function and growth), Manganese (contributing to bone formation), Copper content (vital for iron metabolism), and Selenium (antioxidant).

Whereas Similac 360 Total Care takes the lead in the Copper content which is crucial for iron metabolism.

Price Comparison:

In terms of price, Similac 360 Total Care wins thanks to its affordable prices, compared to Enspire Optimum, with prices ranging from $1.62 to $1.70 per ounce and it has three multiple ready-to-feed sizes (2 fl oz, 8 fl oz, 32 fl oz) which make travel with the formula very easy.

In contrast, the prices of Enspire Optimum range from $1.83 /oz to $2.29 /oz which makes it the expensive one. Furthermore, it doesn’t offer ready-to-use forms.

Frequently Asked Questions:

Which Enfamil is Closest to Breast Milk?

Enfamil Enspire Optimum is the closest Enfamil formula to breast milk, featuring key components like lactoferrin, which supports immune health, and MFGM (Milk Fat Globule Membrane), known for its role in brain development, and HMOs (Human Milk Oligosaccharides). With its blend of nutrients, including 2’-FL & LNnT HMO, vitamins, and minerals, it aims to replicate the benefits of breast milk for infant development.

Which Enfamil is similar to Similac 360 Total Care?

When exploring alternatives to Similac 360 Total Care, Enfamil NeuroPro emerges as a standout choice for discerning parents. It’s GMO-Free and contains triple prebiotics, promoting a robust and balanced gut microbiome for optimal digestive health. Additionally, fortified with Milk Fat Globule Membrane (MFGM) and Human Milk Oligosaccharide 6 (HuMO6), NeuroPro contributes to cognitive development and immune system support, respectively.

Read: Similac 360 Total Care Vs Enfamil Neuropro

Which Similac is Similar to Enfamil Enspire Optimum?

If you are looking for Similac formulas that provide comprehensive nutrition and are designed for overall baby development as Enfamil Enspire Optimum, then Similac Pro-Advance and Similac 360 Total Care are good options:

Similac Pro-Advance: is a well-rounded infant formula that provides essential nutrients for overall growth and development. This formula features the OptiGRO blend, which includes DHA (Docosahexaenoic Acid), lutein, and vitamin E. DHA is crucial for brain development, lutein supports eye health, and vitamin E acts as an antioxidant.

Similac 360 Total Care: This is designed to provide comprehensive support for infant development. Furthermore, this formula is formulated with a combination of nutrients to support immune system development, brain health, and gut health thanks to its 5 HMO (Human Milk Oligosaccharide) prebiotics. HMOs are special prebiotics found in breast milk that contribute to the development of a baby’s immune system and support a healthy gut microbiome.

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