Enfamil Infant and Enfamil Enspire are both standard milk-based formulas for babies with no health issues, made from nonfat milk + whey protein concentrate and 100% lactose, they have as fat source palm oil, soy oil, high oleic safflower oil, and coconut oil. However, they differ in prebiotics, price, and added extra features.
In this article, we will see a complete comparison between Enfamil Infant and Enfamil Enspire regarding mom’s reviews, ingredients, nutrition, and price. Stay with me!!
Mom’s Reviews Comparison:
Most moms have found that both formulas are easy to mix and digest and babies are loving the taste. However, Enspire doesn’t have a small can, the issue here is when you want to try Enspire if it works or not you should buy a small can.
In case your baby drinks these standard milk-based formulas and shows negative reactions (gas – spit-up – fussiness..) then he may have lactose sensitivity or cow’s milk allergy, you should consult your pediatrician to give the right formula type your baby should drink.
The table below shows a comparison between Enspire and the regular Enfamil in terms of mom’s reviews:

Ingredients Comparison:
In terms of ingredients, both formulas have the same protein, carbohydrate, and fat sources as they are both standard milk-based formulas for babies with no health issues.
However, there are some differences in the extra feature and prebiotics, Enfamil Enspire has three added features: Omega 3 DHA, MFGM (milk fat globule membrane) that supports brain development and protects against some infectious diseases, and Lactoferrin which is a protein source that protects against viruses and infections and helps regulate iron absorption by the body.
Furthermore, Enfamil Infant has two prebiotics to promote digestive health (Galactooligosaccharides and Polydextrose) whereas Enspire has three prebiotics one of them is an HMO prebiotic called 2′-Fucosyllactose.
« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott
These are small differences, the most important thing to take into consideration in a formula is the protein, carbohydrate, and fat sources.
The table below shows a comparison between these two formulas in terms of ingredients:

There is another standard milk-based formula similar to Enfamil Infant which is Enfamil Neuropro, I made a comparison between these two if you want to check.
Related: The Best 9 Generic brands of Enfamil Infant
Nutrition Comparison:
In terms of nutrition, Enfamil Infant and Enfamil Enspire have the same nutrients, vitamins, and minerals level except for vitamin D, Enspire has 70 /100cal whereas Enfamil Infant has 60 /100cal.

Related: Enfamil Infant vs Similac 360 Total Care: which one is the best?
Price Comparison:
Regarding price, Enfamil Enspire is more expensive than regular Enfamil and doesn’t have a small size and a ready-to-feed form. The overprice of Enspire is due to its three extra features (Omega 3 DHA, MFGM, Lactoferrin) and the 2′-FL HMO prebiotic.
According to mom’s reviews, both formulas have the same positive reviews which means that these extra features and prebiotics aren’t making a big difference, thus, it’s better to start with Enfamil Infant because it’s cheaper.
To know how much money you will save on Enfamil Infant compared to Enspire, we must know how much formula a baby eats. On average, a baby could drink up to 25 oz per day, that’s almost 9000 oz per year.
Therefore, Enfamil Infant will cost up to 11000 $ whereas Enfamil Enspire will cost up to 17000 $. Thus, you will save 6000$ per year!!
Generic brands are cheaper by half, also they are safe and approved by the FDA. I wrote a lot of articles about generic brands of almost all formulas, you can check them out here.
The table below shows a full comparison between Enfamil Infant and Enspire in terms of price, size, and rating:
ENFAMIL INFANT | ENFAMIL ENSPIRE |
---|---|
12.5 oz 17.26 $ 1.38 /oz 21.1 oz 25.27 $ 1.20 /oz 29.4 oz 35.83 $ 1.22 /oz 32 fl oz 8.98$ 28.1 ¢/fl oz | 20.5 oz 39.98 $ 1.95 /oz 30 oz 56.97 $ 1.90 /oz |
4.8 of 5.0 3133 reviews | 4.8 of 5.0 1693 reviews |
Buy 12.5 oz HERE Buy 21.1 oz HERE Buy 29.4 oz HERE Buy Ready-to-use | Buy 20.5 oz HERE Buy 30 oz HERE |
Can You Mix and Switch Between Enfamil Infant and Enfamil Enspire?
Yes, you can mix and switch between Enfamil Infant and Enfamil Enspire as you want because they are of the same type (standard milk-based formula) made for babies with no health issues.
The Best One?
After this comparison, we conclude that Enfamil Infant is the best because it gives babies the nutritional value they need at less price and doesn’t elicit bad reactions in babies with no sensitivity issues. Furthermore, it’s easy to mix its powder and has good taste.
