Enfamil Gentlease Vs All Enfamil Formulas: The Ultimate Comparison

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Enfamil Gentlease is a formula designed for babies who have allergic responses to lactose and the intact cow’s milk protein by reducing lactose to 20%, the other 80% is from corn syrup solids, and by using partially hydrolyzed nonfat milk protein to ease digestion for your baby.

In this article, we will see a complete comparison between Enfamil Gentlease and all Enfamil formulas to help you choose the right one for your LO.

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Enfamil Gentlease vs Enfamil Neuropro Gentlease:

Enfamil Gentlease vs Neuropro Gentlease

Enfamil Gentlease and Enfamil Neuropro Gentlease are both partially hydrolyzed and lactose-reduced formulas by 80% designed for babies with gas, fussiness, spit-up, crying, and who have negative reactions to lactose and standard milk-based formulas. The difference between them is the 2′-FL HMO prebiotic, the high inositol and Vitamin D levels, and the MFGM (milk fat globule membrane) in the Neropro Gentlease formula that is missing in Enfamil Gentlease. We could say they are very similar and these extra features are made just for marketing.

Furthermore, Enfamil Neuropro Gentlease is available in a ready-to-feed version contrary to Enfamil Gentlease.

A partially hydrolyzed formula is a formula where the protein is broken a little bit in size to be like that found in breastmilk to prevent negative reactions in babies who can’t tolerate the intact protein in regular formula.

I did a full comparison between Enfamil Neuropro Gentlease and all Enfamil formulas if you want to check.

Image source: Nestle Health Science

The MFGM is extracted from whey protein concentrate, it has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).

The inositol level in Enfamil Neuropro Gentlease is 24 mg per 100 calories whereas in breastmilk the level is from 22 to 48mg /100kcal.

Inositol is an essential nutrient required by human cells in culture for growth and survival. Inositol promotes maturation of several components of surfactant and may play a critical role in fetal and early neonatal life.

Says National Library of Medicine

Related: This is The Best Formula For Babies With Colic in 2022!

Can I Switch Between Enfamil Gentlease and Enfamil Neuropro Gentlease?

Yes, you can switch between Enfamil Gentlease and Neuropro Gentlease back and forth because they are both partially hydrolyzed formulas and lactose-reduced by the same percentage (80%). The extra features in the Neuropro Gentlease formula don’t make a big difference and their presence or not doesn’t have any impact on your baby’s health.

Enfamil GentleaseEnfamil NeuroPro Gentlease
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Partially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Whey to Casein Ratio60:4060:40
Carbohydrate source80 % Corn syrup solids
20 % Lactose
80 % Corn syrup solids
20 % Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
Extra FeaturesMFGM
Prebiotics2′-FL HMO
Generic Brands6 Generic brands6 Generic brands
Protein (g)2.3 /100 Cal2.3 /100 Cal
Fat (g)5.3 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.8 /100 Cal10.8 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)2 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal12 /100 Cal
Inositol (mg)6 /100 Cal24 /100 Cal
Calcium (mg)82 /100 Cal82 /100 Cal
Phosphorus (mg)46 /100 Cal46 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal1 /100 Cal
Manganese (mcg)15 /100 Cal15 /100 Cal
Sodium (mg)40 /100 Cal40 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilSchizochytrium sp. oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz

27.7 oz
35.83 $
1.29 /oz
19.5 oz
27.98 $
1.44/oz

27.4 oz
38.36 $
1.40 /oz

35.2 oz
47.46 $
1.35 /oz
Rating4.8 of 5.0
3589 reviews
4.6 of 5
3370 reviews
Ready-to-feedNoYes
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 19.5 oz HERE

Buy 27.4 oz HERE

Buy 35.2 oz HERE

Buy Ready-to-use
Overall Note3/107/10
Enfamil Neuropro Gentlease vs Enfamil Gentlease

Enfamil Gentlease vs Enfamil Infant:

Enfamil Gentlease vs Enfamil regular formula

The difference between Enfamil Gentlease and Enfamil Infant is that the latter is a standard milk-based formula using the intact cow’s milk protein designed for babies with no health issues whereas the Neuropro Gentlease formula is a partially hydrolyzed formula and lactose-reduced made for babies with gas, fussiness, spit-up, crying, and who have bad reactions to lactose and intact cow’s milk protein.

Moreover, Enfamil Infant is cheaper and available in a ready-to-feed version, also it has two prebiotics and 9 generic brands you replace it with while Enfamil Neuropro Gentlease doesn’t have a prebiotic, however, it’s enriched with minerals more than regular Enfamil.

Can I Switch Between Enfamil Gentlease and Enfamil Infant?

In case your baby shows bad reactions to Enfamil Infant like gas, fussiness, or a lot of crying, then switching to Enfamil Gentlease will be a good decision because it’s easy to digest than the regular formula, if it didn’t work either, then you must switch to an extensively hydrolyzed formula (hypoallergenic formula).

However, you can’t switch from Enfamil Gentlease to Enfamil Infant if your baby is diagnosed as sensitive to lactose or intact cow’s milk, unless he recovers from this sensitivity and you want to save some money, then go ahead.

Enfamil GentleaseEnfamil Infant
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio60:4060:40
Carbohydrate source80 % Corn syrup solids
20 % Lactose
100% Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
Prebiotics– Galactooligosaccharides
– Polydextrose
Generic Brands6 Generic brands9 Generic brands
Protein (g)2.3 /100 Cal2 /100 Cal
Fat (g)5.3 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.8 /100 Cal11.3 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal12 /100 Cal
Inositol (mg)6 /100 Cal6 /100 Cal
Calcium (mg)82 /100 Cal78 /100 Cal
Phosphorus (mg)46 /100 Cal43 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal1 /100 Cal
Manganese (mcg)15 /100 Cal 15 /100 Cal
Sodium (mg)40 /100 Cal27 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz

27.7 oz
35.83 $
1.29 /oz
12.5 oz
17.26 $
1.38 /oz

21.1 oz
25.27 $
1.20 /oz

29.4 oz
35.83 $
1.22 /oz
Rating4.8 of 5.0
3589 reviews
4.4 of 5
117 reviews
Ready-to-feedNoYes
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 12.5 oz HERE

Buy 21.1 oz HERE

Buy 29.4 oz HERE

Buy Ready-to-use
Enfamil Regular Formula vs Enfamil Gentlease

Enfamil Gentlease vs Enfamil Reguline:

Enfamil Gentlease vs Enfamil Reguline

Enfamil Gentlease and Enfamil Reguline are both partially hydrolyzed and lactose-reduced formulas and they have the same ingredients. However, Enfamil Reguline is lactose-reduced by 50% and has two prebiotics, also it has a low iron level which makes it good for constipation, whereas Enfamil Gentlease is lactose-reduced by 80% and available in big cans, also it’s slightly cheaper, but, it doesn’t contain a prebiotic.

Can I Switch Between Enfamil Gentlease and Enfamil Reguline?

Your baby may experience constipation on Enfamil Gentlease because it doesn’t have prebiotics, thus, switching to Enfamil Reguline will be a good decision as many moms did because of the low iron level and the presence of two prebiotics.

Your baby can take both formulas interchangeably because they are of the same type (partially hydrolyzed formula) and have the same amount of vitamins and minerals.

Enfamil GentleaseEnfamil Reguline
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Partially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Whey to Casein Ratio60:4060:40
Carbohydrate source80 % Corn syrup solids
20 % Lactose
50 % Corn syrup solids
50 % Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
PrebioticsGalactooligosaccharides
polydextrose
Generic Brands6 Generic brands6 Generic brands
Protein (g)2.3 /100 Cal2.3 /100 Cal
Fat (g)5.3 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.8 /100 Cal11.1 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal12 /100 Cal
Inositol (mg)6 /100 Cal6 /100 Cal
Calcium (mg)82 /100 Cal82 /100 Cal
Phosphorus (mg)46 /100 Cal46 /100 Cal
Iron (mg)1.8 /100 Cal1.5 /100 Cal
Zinc (mg)1 /100 Cal1 /100 Cal
Manganese (mcg)15 /100 Cal15 /100 Cal
Sodium (mg)40 /100 Cal36 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz


27.7 oz
35.83 $
1.29 /oz
12.4 oz
18.72 $
1.51 /oz

19.5 oz
29.98 $
1.54/oz
Rating4.8 of 5.0
3589 reviews
4.8 of 5.0
984 reviews
Ready-to-feedNoNo
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 12.4 oz HERE

Buy 19.5 oz HERE
Enfamil Reguline vs Enfamil Gentlease

Enfamil Gentlease vs Enfamil Enspire:

Enfamil Gentlease vs Enfamil Enspire

The difference between Enfamil Gentlease and Enfamil Enspire is that the latter is a standard milk-based formula made for babies with no sensitivity problems whereas the Gentlease formula is partially hydrolyzed and lactose-reduced formula by 80% designed for babies with gas, fussiness, spit-up, crying, and who have allergic responses to lactose and standard milk-based formulas.

Lactoferrin is a protein source for Enfamil Enspire, it has a lot of benefits; like protecting against viruses and infections. Also, it helps regulate iron absorption by the body.

Whey protein-lipid concentrate is a source of MFGM (milk fat globule membrane), it has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).

Can I Switch Between Enfamil Gentlease and Enfamil Enspire?

You can switch from Enfamil Enspire to Enfamil Gentlease in case your baby has shown allergic responses to the first formula. However, you can’t do the opposite if your baby still has a sensitivity to lactose or intact cow’s milk protein.

Enfamil GentleaseEnfamil Enspire
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Nonfat Milk
Whey Protein Concentrate
Lactoferrin
Whey protein-lipid concentrate
Whey to Casein Ratio60:4060:40
Carbohydrate source80 % Corn syrup solids
20 % Lactose
100% Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
PrebioticsGalactooligosaccharides
polydextrose
Extra FeaturesOmega 3 DHA
Lactoferrin
MFGM
Generic Brands6 Generic brands9 Generic brands
Protein (g)2.3 /100 Cal2.1 /100 Cal
Fat (g)5.3 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.8 /100 Cal11.3 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)2 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal12 /100 Cal
Inositol (mg)6 /100 Cal24 /100 Cal
Calcium (mg)82 /100 Cal78 /100 Cal
Phosphorus (mg)46 /100 Cal43 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal1 /100 Cal
Manganese (mcg)15 /100 Cal15 /100 Cal
Sodium (mg)40 /100 Cal27 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz


27.7 oz
35.83 $
1.29 /oz
20.5 oz
39.98 $
1.95 /oz

30 oz
56.97 $
1.90 /oz
Rating4.8 of 5.0
3589 reviews
4.8 of 5
1671 reviews
Ready-to-feedNoNo
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 20.5 oz HERE

Buy 30 oz HERE
Enfamil Enspire vs Enfamil Gentlease

Enfamil Gentlease vs Enfamil Neuropro Sensitive:

Enfamil Gentlease vs Enfamil Neuropro Sensitive

Enfamil Gentlease and the Neuropro Sensitive formulas are both lactose-reduced; the latter is by 99% and the first is by 80%. However, they have different protein sources; the Gentlease formula is using partially hydrolyzed nonfat milk whereas the other is using milk protein isolate.

Furthermore, the NeuroPro Sensitive formula has the 2′-FL HMO prebiotic and MFGM (milk fat globule membrane) extracted from whey protein-lipid concentrate, also it’s enriched with minerals more than Enfamil Gentlease. However, it’s available only in one size.

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

Can I Switch Between Enfamil Gentlease and Enfamil Neuropro Sensitive?

Enfamil GentleaseEnfamil Neuropro Sensitive
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
70%  Milk Protein Isolate
30% whey protein-lipid concentrate
Whey to Casein Ratio60:4060:40
Carbohydrate source80 % Corn syrup solids
20 % Lactose
– 1% Lactose
– 99% Corn Syrup
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
Prebiotics2′-FL HMO
Extra FeaturesMFGM
Generic Brands6 Generic brands7 Generic brands
Protein (g)2.3 /100 Cal2.2 /100 Cal
Fat (g)5.3 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.8 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)2 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal12 /100 Cal
Inositol (mg)6 /100 Cal24 /100 Cal
Calcium (mg)82 /100 Cal88 /100 Cal
Phosphorus (mg)46 /100 Cal59 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal1 /100 Cal
Manganese (mcg)15 /100 Cal15 /100 Cal
Sodium (mg)40 /100 Cal33 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilSchizochytrium sp. oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz


27.7 oz
35.83 $
1.29 /oz
19.5 oz
30.28 $
1.55 /oz
Rating4.8 of 5.0
3589 reviews
4.8 of 5.0
587 reviews
Ready-to-feed?NoNo
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 19.5 oz HERE
Enfamil Neuropro sensitive vs Enfamil Gentlease

Final Thoughts:

Among all these formulas, the best alternative for Enfamil Gentlease in the Enfamil brand is the Neuropro Gentlease and Enfamil Reguline formula because they are of the same type (partially hydrolyzed and lactose-reduced formulas) they are using the same protein, carbohydrate, and fat sources. In terms of price, Enfamil Gentlease is cheaper than other formulas.

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