Enfamil Gentlease is a formula designed for babies who have allergic responses to lactose and the intact cow’s milk protein by reducing lactose to 20%, the other 80% is from corn syrup solids, and by using partially hydrolyzed nonfat milk protein to ease digestion for your baby.
In this article, we will see a complete comparison between Enfamil Gentlease and all Enfamil formulas to help you choose the right one for your LO.
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Enfamil Gentlease vs Enfamil Neuropro Gentlease:

Enfamil Gentlease and Enfamil Neuropro Gentlease are both partially hydrolyzed and lactose-reduced formulas by 80% designed for babies with gas, fussiness, spit-up, crying, and negative reactions to lactose and standard milk-based formulas.
The difference between them is the 2′-FL HMO prebiotic, the high inositol and Vitamin D levels, and the MFGM (milk fat globule membrane) in the Neropro Gentlease formula that is missing in Enfamil Gentlease. We could say they are very similar and these extra features are made just for marketing.
Furthermore, Enfamil Neuropro Gentlease is available in a ready-to-feed version contrary to Enfamil Gentlease.
A partially hydrolyzed formula is a formula where the protein is broken a little bit in size to be like that found in breast milk to prevent negative reactions in babies who can’t tolerate the intact protein in regular formula.

I did a full comparison between Enfamil Neuropro Gentlease and all Enfamil formulas if you want to check.
The MFGM is extracted from whey protein concentrate, it has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).
Nutrition Information:
Enfamil Gentlease and Neuropro Gentlease have almost the same nutrient, vitamins, and minerals levels. However, they differ in the inositol and vitamin D level.
The inositol level in Enfamil Neuropro Gentlease is 24 mg per 100 calories whereas in breastmilk the level is from 22 to 48mg /100kcal.
Inositol is an essential nutrient required by human cells in culture for growth and survival. Inositol promotes maturation of several components of surfactant and may play a critical role in fetal and early neonatal life.
Says National Library of Medicine

Related: Best 6 Generic brands of Enfamil Neuropro Gentlease.
Can I Switch Between Enfamil Gentlease and Enfamil Neuropro Gentlease?
Yes, you can switch between Enfamil Gentlease and Neuropro Gentlease back and forth because they are both partially hydrolyzed formulas and lactose-reduced by the same percentage (80%). The extra features in the Neuropro Gentlease formula don’t make a big difference and their presence or not doesn’t have any impact on your baby’s health.
Price and Rating:
Enfamil Gentlease and Neuropro Gentlease have the same price except for the 27.7 oz cans, Gentlease is slightly cheaper. In terms of moms’ reviews, Enfamil Gentlease got a good rating.
Enfamil Gentlease | Enfamil NeuroPro Gentlease |
---|---|
12.4 oz 18.26 $ 1.47/oz 19.9 oz 28.30 $ 1.42 /oz 27.7 oz 35.83 $ 1.29 /oz | 19.5 oz 27.98 $ 1.44/oz 27.4 oz 38.36 $ 1.40 /oz 35.2 oz 47.46 $ 1.35 /oz |
4.8 of 5.0 3589 reviews | 4.6 of 5 3370 reviews |
No RTF form | It has an RTF |
Buy 12.4 oz HERE Buy 19.9 oz HERE Buy 27.7 oz HERE | Buy 19.5 oz HERE Buy 27.4 oz HERE Buy 35.2 oz HERE Buy Ready-to-use |
Enfamil Gentlease vs Enfamil Enspire:

The difference between Enfamil Gentlease and Enfamil Enspire is that the latter is a standard milk-based formula made for babies with no sensitivity problems whereas the Gentlease formula is partially hydrolyzed and lactose-reduced formula by 80% designed for babies with gas, fussiness, spit-up, crying, and who have allergic responses to lactose and standard milk-based formulas.

Lactoferrin is a protein source for Enfamil Enspire, it has a lot of benefits; like protecting against viruses and infections. Also, it helps regulate iron absorption by the body.
Whey protein-lipid concentrate is a source of MFGM (milk fat globule membrane), it has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).
Nutrition Information:
Enfamil Enspire has a high inositol and vitamin D level than Gentlease. However, Gentlease is enriched with calcium, phosphorus, and sodium more than Enspire.
The table below shows a comparison between Gentlease and Enspire in terms of nutrients, vitamins, and minerals:

Can I Switch Between Enfamil Gentlease and Enfamil Enspire?
You can switch from Enfamil Enspire to Enfamil Gentlease in case your baby has shown allergic responses to the first formula. However, you can’t do the opposite if your baby still has a sensitivity to lactose or intact cow’s milk protein.
Price and Rating:
Enfamil Gentlease is way cheaper than Enspire for all sizes. Enspire is expensive because of the features added like Lactoferrin, Omega 3 DHA, MFGM, and triple prebiotics, which makes it the closest one to breast milk.
However, the “closest formula to breast milk” is a sort of marketing made by baby formula brands to attract moms that want to give the best for their babies.
All baby formulas are approved by the FDA, which means that they give the baby the nutrients value he needs. Furthermore, the “extra features” are not extracted from human milk but from cow’s milk, so…
The table below shows a comparison between Gentlease and Enspire in terms of price and rating:
Enfamil Gentlease | Enfamil Enspire |
---|---|
12.4 oz 18.26 $ 1.47/oz 19.9 oz 28.30 $ 1.42 /oz 27.7 oz 35.83 $ 1.29 /oz | 20.5 oz 39.98 $ 1.95 /oz 30 oz 56.97 $ 1.90 /oz |
4.8 of 5.0 3589 reviews | 4.8 of 5 1671 reviews |
No RTF | No RTF |
Buy 12.4 oz HERE Buy 19.9 oz HERE Buy 27.7 oz HERE | Buy 20.5 oz HERE Buy 30 oz HERE |
To know how much money we will save on Enfamil Gentlease, we should see how much formula a baby drinks (I did a full guide with an infographic about this subject if you want to check HERE)
A baby drinks about 25 oz of formula per day in the first 6 months. On average, Gentlease costs 1.42 /oz which means you’ll spend 35.5 $ per day and 1065 $ per month whereas on the Enspire formula you will spend 1425 $ monthly. That’s an extra 360 $ per month!!
In case you want to save more money, generic brands are the best way because they are cheaper almost by half!!
Enfamil Gentlease vs Enfamil Neuropro Sensitive:

Enfamil Gentlease and the Neuropro Sensitive formulas are both lactose-reduced; the latter is by 99% and the first is by 80%. However, they have different protein sources; the Gentlease formula uses partially hydrolyzed nonfat milk whereas the other uses milk protein isolate.

Furthermore, the NeuroPro Sensitive formula has the 2′-FL HMO prebiotic and MFGM (milk fat globule membrane) extracted from whey protein-lipid concentrate, also it’s enriched with minerals more than Enfamil Gentlease. However, it’s available only in one size.
« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott
Nutrition Comparison:

Related: Best 7 generic brands of Neuropro Sensitive.
Price and Rating:
Neuropro Sensitive has only one available size and it’s more expensive than Gentlease, the more available sizes the better for three reasons, small sizes are good for testing the formula, big sizes are good for saving money, and it’s easy to find in stores.
Enfamil Gentlease | Enfamil Neuropro Sensitive |
---|---|
12.4 oz 18.26 $ 1.47/oz 19.9 oz 28.30 $ 1.42 /oz 27.7 oz 35.83 $ 1.29 /oz | 19.5 oz 30.28 $ 1.55 /oz |
4.8 of 5.0 3589 reviews | 4.8 of 5.0 587 reviews |
No RTF | No RTF |
Buy 12.4 oz HERE Buy 19.9 oz HERE Buy 27.7 oz HERE | Buy 19.5 oz HERE |
Enfamil Gentlease vs Enfamil Reguline:

Enfamil Gentlease and Enfamil Reguline are both partially hydrolyzed and lactose-reduced formulas and they have the same ingredients. However, Enfamil Reguline is lactose-reduced by 50% and has two prebiotics, also it has a low iron level which makes it good for constipation, whereas Enfamil Gentlease is lactose-reduced by 80% and available in big cans at a cheaper price, but, it doesn’t contain a prebiotic.

Nutrition Comparison:

Can I Switch Between Enfamil Gentlease and Enfamil Reguline?
Your baby may experience constipation on Enfamil Gentlease because it doesn’t have prebiotics, thus, switching to Enfamil Reguline will be a good decision as many moms did because of the low iron level and the presence of two prebiotics.
Your baby can take both formulas interchangeably because they are of the same type (partially hydrolyzed formula) and have the same amount of vitamins and minerals.
Price and Rating:
Enfamil Gentlease | Enfamil Reguline |
---|---|
12.4 oz 18.26 $ 1.47/oz 19.9 oz 28.30 $ 1.42 /oz 27.7 oz 35.83 $ 1.29 /oz | 12.4 oz 18.72 $ 1.51 /oz 19.5 oz 29.98 $ 1.54/oz |
4.8 of 5.0 3589 reviews | 4.8 of 5.0 984 reviews |
No RTF | No RTF |
Buy 12.4 oz HERE Buy 19.9 oz HERE Buy 27.7 oz HERE | Buy 12.4 oz HERE Buy 19.5 oz HERE |
Final Thoughts:
Among all these formulas, the best alternative for Enfamil Gentlease in the Enfamil brand is the Neuropro Gentlease and Enfamil Reguline formulas because they are of the same type (partially hydrolyzed and lactose-reduced formulas) they are using the same protein, carbohydrate, and fat sources. In terms of price, Enfamil Gentlease is cheaper than other formulas.