Similac 360 Total Care Vs Enfamil Gentlease: Which One to Choose?

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Key Differences?

Similac 360 Total Care and Enfamil Gentlease are two distinct infant formulas with notable differences:

Similac 360 Total Care is tailored for healthy babies without specific health issues, featuring a protein source of nonfat milk and whey protein concentrate, a whey to casein ratio of 48:52, and 100% lactose as the carbohydrate source. It includes extra features like a blend of DHA, lutein, and vitamin E, prebiotics, and is GMO-free with no palm oil.

On the other hand, Enfamil Gentlease is formulated to alleviate fussiness, gas, crying, and spit-up, containing partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), with a 60:40 whey to casein ratio and a carbohydrate composition of 20% lactose and 80% corn syrup solids. Enfamil Gentlease does not have additional features like DHA or lutein, is not labeled GMO-free, and contains palm oil. 

Which One to Choose?

Choosing between Similac 360 Total Care and Enfamil Gentlease depends on various factors such as your baby’s specific needs, preferences, and any health recommendations from healthcare providers. Here’s a breakdown of the key features of each formula to help you make an informed decision:

Baby’s Health Status:

  • Similac 360 Total Care: Designed for healthy babies without specific health issues.
  • Enfamil Gentlease: Formulated to ease fussiness, gas, crying, and spit-up.

Nutritional Components:

Similac 360 Total Care:

  • Contains a blend of DHA, lutein, and vitamin E, which are beneficial for eye and brain development.
  • Includes prebiotics, specifically 5 HMO prebiotics, which can support gut health.
  • GMO-free with no palm oil, which might be preferable for some parents.
  • High carbohydrate levels, which can provide sustained energy for your baby.

Enfamil Gentlease:

  • Contains partially hydrolyzed protein and reduced lactose by 80%, making it easier to digest and potentially reducing fussiness and gas.
  • High protein and fat content, which can be beneficial for growth and development.
  • High mineral levels, which contribute to overall nutrition but might need to be monitored, especially if your baby has specific health concerns related to mineral intake.

Form and Convenience:

  • Similac 360 Total Care offers ready-to-feed options in various sizes (2 fl oz, 8 fl oz, and 32 fl oz), which can be convenient for travel or nighttime feedings.
  • Enfamil Gentlease may come in similar ready-to-feed options, but the availability can vary.

Personal Preferences and Considerations:

  • Some parents prefer formulas without certain additives like palm oil or GMO ingredients, in which case Similac 360 Total Care might be preferable.
  • If your baby has shown symptoms of fussiness, gas, or spit-up, Enfamil Gentlease’s specific formulation for these issues is more suitable.

In summary, if your baby is generally healthy and you prioritize a formula with additional nutritional benefits like DHA and prebiotics, Similac 360 Total Care will be a good choice. On the other hand, if your baby is experiencing issues like fussiness or gas due to lactose sensitivity or intact cow’s milk protein, Enfamil Gentlease’s specialized formula will provide the relief your baby needs.

Mom’s Reviews Comparison:

Enfamil Gentlease:

Positive Reviews:

  • Effective Gas Relief: Numerous moms praised this formula for effectively reducing gas discomfort in their infants, leading to a happier, more comfortable baby.
  • Gentle on Sensitive Stomachs: Parents with babies prone to stomach sensitivity appreciated how this formula was gentle and easy to digest.
  • Colic Soothing Properties: Many reviews highlighted the formula’s ability to alleviate colic symptoms, providing relief for both babies and parents.
  • Reduced Spit-Up: Several users noted a decrease in spit-up occurrences, indicating improved digestion and comfort for their babies.

Negative Reviews:

  • Spit-Up Concerns: Some mothers reported an increase in spit-up incidents after switching to Enfamil Gentlease, which may not work well for all babies.
  • Stool Color Changes: A few reviews mentioned concerns about unusual or dark stool colors, prompting some parents to seek clarification from healthcare providers.
  • Availability Challenges: Difficulty in finding Enfamil Gentlease in stores was a common issue for some parents, leading to inconvenience and added stress.

Similac 360 Total Care:

Positive Reviews:

  • Delightful Taste: Many moms raved about the pleasant taste of Similac 360 Total Care, making it easier for picky eaters to accept and enjoy.
  • Travel-Friendly: Parents found this formula convenient for travel, thanks to its multiple ready-to-feed forms (2 fl oz, 8 fl oz, and 32 fl oz).
  • User-Friendly Preparation: Users appreciated the straightforward and quick preparation process of Similac 360 Total Care, saving time and hassle.
  • Effective Gas Relief: Similar to Enfamil Gentlease, this formula was commended for its ability to reduce gas and discomfort in babies.
  • Gentle on Digestion: Positive feedback emphasized how gentle and soothing this formula was on babies’ delicate stomachs.

Negative Reviews:

  • Taste Discrepancies: Some mothers reported that their babies did not take well to the taste of Similac 360 Total Care, leading to feeding challenges for a few families.

Ingredients Comparison:

Age Range:

Both Enfamil Gentlease and Similac 360 Total Care are suitable for infants aged 0 to 12 months, providing essential nutrition during this critical period of growth and development.

Protein Source:

Enfamil Gentlease utilizes a blend of partially hydrolyzed nonfat milk and whey protein concentrate solids derived from soy. This means that the proteins in the formula have been broken down into smaller fragments, making them easier to digest, which can be beneficial for infants with sensitive stomachs.

Similac 360 Total Care, on the other hand, relies on nonfat milk and whey protein concentrate as its primary protein sources, which provide essential amino acids necessary for healthy growth and development.

Whey to Casein Ratio:

Enfamil Gentlease has a whey to casein ratio of 60:40, which means it contains more whey protein than casein protein. Whey protein digests more quickly and is often gentler on the stomach, which can be beneficial for infants who experience digestive discomfort.

Similac 360 Total Care has a slightly different ratio of 48:52, providing a balance of whey and casein proteins for overall nutrition. This ratio may offer benefits for infants who require a different protein balance.

Carbohydrate Source:

Enfamil Gentlease contains a combination of 20% lactose and 80% corn syrup, providing energy and nutrition. Lactose is the primary carbohydrate found in breast milk and is easily digestible, while corn syrup serves as an alternative carbohydrate source to ensure adequate nutrition.

Similac 360 Total Care relies solely on lactose, the primary carbohydrate in breast milk. This ensures optimal digestibility and nutrient absorption, as lactose closely mimics the carbohydrate composition of breast milk.

Fat Sources:

Enfamil Gentlease incorporates various oils such as palm oil, high oleic sunflower oil, soy oil, and coconut oil, along with DHA and ARA for brain and eye development. These fats provide essential fatty acids necessary for healthy growth and development.

Similac 360 Total Care includes high oleic safflower oil, soy oil, and coconut oil, supplemented with DHA, lutein, and vitamin E for enhanced nutritional support. These fats also provide essential fatty acids and additional nutrients for infant development.

Extra Features and prebiotics:

Enfamil Gentlease does not include additional features beyond its core nutritional components.

Similac 360 Total Care offers a blend of DHA, lutein, and vitamin E, providing added benefits for infant development. DHA is important for brain development, lutein supports eye health, and vitamin E acts as an antioxidant.

Furthermore, it incorporates a blend of five human milk oligosaccharides (HMOs) as prebiotics, each playing a crucial role in fostering a healthy gut microbiome and supporting digestive health in infants. These HMOs include 2′-Fucosyllactose (2′-FL), Lacto-N-Tetraose, 3-Fucosyllactose, 6′-Sialyllactose, and 3′-Sialyllactose. 2′-FL, one of the most abundant HMOs in breast milk, nourishes beneficial bacteria in the gut, contributing to immune system development and gastrointestinal health.


Enfamil Gentlease is not labeled as GMO-Free, indicating potential use of genetically modified ingredients. While the safety and efficacy of GMOs in infant formula remain a topic of debate, some parents may prefer formulas with non-GMO ingredients for personal or philosophical reasons.

Similac 360 Total Care is certified GMO-Free, assuring parents concerned about genetically modified organisms in infant formula. This designation may appeal to parents seeking formulas with minimal processing and a focus on natural ingredients.

Nutrients Profile:

Macronutrients and Vitamins:

In terms of macronutrients, Enfamil Gentlease has a higher level of protein and carbohydrate to provide more growth and development to babies whereas 360 Total Care has a higher level of fat which is essential for brain development and function, aiding in the absorption of fat-soluble vitamins, and providing concentrated energy for growing infants.

In terms of vitamins, Enfamil Gentlease is fortified more with Vitamin E (Acts as an antioxidant, protecting cells from damage and supporting immune function), Vitamin K (Essential for blood clotting and bone metabolism), Vitamin B12 (Essential for red blood cell formation and neurological function), Folic acid (Vital for cell division and DNA synthesis, particularly during periods of rapid growth), and Vitamin C (Aids in the synthesis of collagen, promotes wound healing, and enhances immune function).

In contrast, 360 Total Care is enriched more with Vitamin B1 (Helps the body convert carbohydrates into energy and supports nervous system function), Vitamin B2 (Supports growth, energy production, and healthy skin), Niacin (Supports energy metabolism and proper functioning of the nervous and digestive systems), Biotin (Supports healthy hair, skin, and nails, and plays a role in metabolism), and Inositol (Supports cell membrane structure and function, and may play a role in nerve signaling).


Enfamil Gentlease is enriched more with minerals including Calcium (Essential for bone development and overall growth in infants), Phosphorus (Vital for bone health and energy metabolism in babies), Magnesium (Important for muscle and nerve function in infants), Zinc (Supports immune function and growth in infants), Manganese (Plays a role in bone formation and metabolism in babies), Selenium (Acts as an antioxidant and supports immune function in infants), Sodium (Regulates fluid balance and nerve function in babies), Potassium (Important for muscle function and overall growth in infants).

Price Comparison:

Enfamil Gentlease tends to have a slightly lower price per ounce compared to Similac 360 Total Care across most sizes. For example, in the 19.9 oz vs. 20.6 oz comparison, Enfamil Gentlease is priced at $1.65 per ounce, whereas Similac 360 Total Care is priced at $1.70 per ounce. Similarly, in the 27.7 oz vs. 30.8 oz comparison, both formulas are priced at approximately $1.62 per ounce, but Enfamil Gentlease offers a slightly lower price point.

However, it’s important to note that Similac 360 Total Care offers a ready-to-feed option, which is convenient for travel and night feeding. This option is available in smaller quantities such as 2 fl oz and 8 fl oz, with prices ranging from approximately 62.41 cents to 34.75 cents per fluid ounce.

Where to Buy?

Buy 12.4 ozBuy 20.6 oz
Buy 19.9 ozBuy 30.8 oz
Buy 27.7 ozBuy 2-fl-oz
Buy 8-fl-oz
Buy 32-fl-oz

Alternatives to Similac 360 Total Care:

Enfamil NeuroPro:

Enfamil’s NeuroPro formula is enriched with MFGM (Milk Fat Globule Membrane) and DHA (Docosahexaenoic Acid), essential components found in breast milk. These nutrients support brain development, cognitive function, and overall growth in infants. NeuroPro aims to provide babies with comprehensive nutrition to support their developmental milestones. Read Similac 360 Total Care Vs Enfamil Neuropro.

Enfamil Enspire Optimum:

Enspire Optimum is a premium infant formula that goes beyond basic nutrition. It combines immune-supporting ingredients like lactoferrin and prebiotics with essential fatty acids such as DHA and ARA. Lactoferrin helps support the immune system, while prebiotics promote a healthy gut microbiome. This formula is designed to provide infants with optimal nutrition for their growth and development. Read Enfamil Enspire Optimum Vs Similac 360 Total Care.

Similac Pro Advance:

Similac Pro Advance features OptiGRO™, a unique blend of DHA, lutein, and vitamin E. DHA supports brain development, lutein supports eye health, and vitamin E acts as an antioxidant. Pro Advance aims to provide infants with essential nutrients to support their overall growth and development during the critical first year of life. Read Similac Pro Advance vs Similac 360 Total Care.

Gerber Good Start Gentle:

Gerber Good Start Gentle formula is formulated with comfort proteins that are easy to digest, making it suitable for infants with sensitive stomachs or fussiness. The gentle proteins in this formula help promote gentle nourishment and ease digestive discomfort, providing infants with the nutrition they need for healthy growth and development. Read Similac 360 Total Care Vs Gerber Good Start Gentle.

HiPP Combiotic:

HiPP Combiotic is an organic formula that contains prebiotics, vitamins, and essential fatty acids. Prebiotics support digestive health by nourishing beneficial gut bacteria, while vitamins and fatty acids contribute to overall growth and development. HiPP Combiotic offers a natural and organic alternative for parents looking for high-quality infant nutrition.

Alternatives to Enfamil Gentlease:

Enfamil NeuroPro Gentlease:

Enfamil NeuroPro Gentlease offers the same gentle protein blend as Enfamil Gentlease, with the added benefits of MFGM and DHA. MFGM supports brain development and cognitive function, while DHA is essential for brain and eye development. NeuroPro Gentlease aims to provide infants with gentle nutrition to support their overall growth and development. Read Enfamil Gentlease Vs Enfamil Neuropro Gentlease.

Enfamil Reguline:

Enfamil Reguline is specially formulated to promote soft stools and ease occasional digestive discomfort in infants. It contains a blend of prebiotics and gentle proteins that support digestive health and promote regularity. Reguline is designed to provide infants with comfortable and gentle nutrition for optimal digestive function.

Gerber Good Start Gentle Pro:

Gerber Good Start Gentle Pro formula features comfort proteins and prebiotics to support digestion and promote a healthy gut microbiome. The addition of prebiotics helps nourish beneficial gut bacteria, while comfort proteins ensure easy digestion and gentle nourishment for infants. Read Enfamil Gentlease Vs Gerber Good Start.

Gerber Good Start SoothePro:

Gerber Good Start SoothePro is designed for infants experiencing excessive crying and fussiness, often associated with colic. It contains comforting probiotics that help reduce colic symptoms and promote digestive comfort. SoothePro aims to provide relief for colicky babies while supporting their digestive health.

Similac Total Comfort:

Similac Total Comfort is formulated with partially broken-down proteins and easy-to-digest carbohydrates, making it suitable for infants with sensitive stomachs or fussiness. It aims to provide gentle and comfortable nutrition for babies who may experience digestive discomfort or gastrointestinal issues. Read Similac Total Comfort Vs. Enfamil Gentlease.


In conclusion, when faced with the decision between Similac 360 Total Care and Enfamil Gentlease, there are several important factors to consider. Both formulas offer unique benefits tailored to different needs and preferences. Similac 360 Total Care is ideal for healthy babies, providing a blend of essential nutrients like DHA and prebiotics without palm oil or GMO ingredients. On the other hand, Enfamil Gentlease is designed to alleviate issues such as fussiness and gas, thanks to its partially hydrolyzed protein and reduced lactose content.

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