Enfamil Gentlease Vs Enfamil Neuropro Gentlease: What’s The Difference?

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Key Differences Between Gentlease and Neuropro Gentlease?

Enfamil Gentlease and Enfamil Neuropro Gentlease are partially hydrolyzed formulas that share the same protein, fat, and carbohydrate sources but differ in their additional components:

While Gentlease is designed to ease fussiness, gas, and crying, Neuropro Gentlease goes further with added features like MFGM, 2′-FL HMO, and HuMO 6 to address not only those issues but also help reduce spit-up. Neuropro Gentlease is a more comprehensive option for infant digestive comfort.

enfamil gentlease vs neuropro gentlease in terms of ingredients

The Best One?

The choice between Enfamil Gentlease and Enfamil Neuropro Gentlease depends on your baby’s specific needs and preferences. Both formulas are designed to address common digestive issues and are suitable for infants with mild intact milk protein allergy and lactose sensitivity.

However, Enfamil Neuropro Gentlease has additional components like MFGM and 2′-FL HMO that may provide benefits for brain and immune system development. If you’re looking for a formula with these added features, Neuropro Gentlease could be the better choice but keep in mind that is pricy.

Parent Reviews Comparison:

Enfamil Neuropro Gentlease and Enfamil Gentlease have garnered varying parent reviews based on their respective qualities:

enfamil gentlease vs enfamil neuropro gentleasein terms of user reviews

Enfamil Neuropro Gentlease :

Positive Reviews:

  1. Alleviates Gas and Spit-up: Many parents praise Neuropro Gentlease for its effectiveness in addressing common infant issues like gas and spit-up. Babies often experience digestive discomfort due to their developing digestive systems, and this formula seems to significantly reduce these problems, leading to happier, more contented infants.
  2. Gentle on Baby’s Stomach: Neuropro Gentlease is frequently lauded for being gentle on a baby’s sensitive stomach thanks to its HuMO6 immune and gentle blend.
  3. Reduces Fussiness and Colic: Parents appreciate that this formula aids in reducing fussiness and colic symptoms. This is a crucial benefit, as colic can be very distressing for both infants and their parents. The soothing effects of this formula can lead to more peaceful days and nights.
  4. Improved Sleep for Baby: Perhaps one of the most significant benefits reported by parents is improved sleep for their babies. When infants experience less discomfort, they tend to sleep more soundly, which is a relief for parents who are often sleep-deprived during the early months of their child’s life.

Negative Reviews:

  1. Expensive: One of the common drawbacks cited by some parents is the cost of Enfamil Neuropro Gentlease. It is often perceived as a premium formula, which might strain the budget for some families.
  2. Taste and Smell: A few parents have expressed concerns about the taste and smell of this formula. While babies’ preferences vary, some may find the taste less agreeable, potentially leading to feeding challenges.
  3. May Cause Constipation/Gas: In a minority of cases, some parents have reported that this formula might lead to constipation or gas issues in their infants. However, it’s essential to remember that every baby is different, and what works well for one may not for another.

Related: Enfamil Neuropro Gentlease Vs Neuropro Care: What’s The Difference?

Enfamil Gentlease:

Positive Reviews:

  1. Effectiveness for Gas: Enfamil Gentlease is frequently commended for its effectiveness in reducing gas-related discomfort in infants. It’s a reassuring choice for parents whose babies are often gassy or fussy after feedings.
  2. Good for Sensitive Stomachs: This formula is known for being suitable for infants with sensitive stomachs. For babies who struggle with standard formula options, Gentlease provides a gentler alternative.
  3. Less Colic: Parents have reported that this formula helps reduce colic symptoms, which can lead to a more peaceful and less stressful feeding experience.
  4. Less Spit-up: Enfamil Gentlease is also credited for its role in reducing incidents of spit-up, helping to keep babies more comfortable and less messy.

Negative Reviews:

  1. Bad Taste: The primary issue noted by some parents is related to the taste of Enfamil Gentlease. Not all babies may find the taste to their liking, and this can sometimes lead to difficulties in transitioning to the formula.

Related: Enfamil Gentlease Vs Enfamil Infant: Full Comparison

Ingredients Comparison:

Age Range:

Both Enfamil Gentlease and Enfamil Neuropro Gentlease are suitable for infants from birth to 12 months of age. This age range ensures that parents have a consistent and appropriate nutritional option for their growing baby, whether they are newborns or approaching their first birthday.

Protein Source and Whey to Casein Ratio:

Partially hydrolyzed nonfat milk and whey protein concentrate solids from soy in both formulas ensure that infants receive a blend of proteins that are easier to digest. The balanced whey-to-casein ratio is crucial because it mirrors the composition of breast milk, making it gentle on the stomach while providing essential amino acids for growth and development.

The nonfat milk in both Enfamil Gentlease and Enfamil Neuropro Gentlease formulas has undergone a partial enzymatic breakdown, making it easier for infants to digest. The process breaks down complex proteins into smaller, more manageable components, reducing the risk of digestive discomfort and allergies. This makes it a gentle and suitable protein source for infants with sensitive stomachs, helping to alleviate common feeding-related issues such as gas, fussiness, and colic.

Carbohydrate Source:

The combination of 20% lactose and 80% corn syrup solids in both formulas is an essential aspect of their design. Notably, these formulas are labeled as “lactose-reduced by 80% compared to regular formulas,” making them suitable for infants with mild lactose sensitivity.

In the ready-to-use form of Neuropro Gentlease the carbohydrate source is slightly different, it has lactose, corn syrup solids, and rice starch.

Related: Enfamil Gentlease Vs Enfamil Sensitive: What’s The Difference?

Fat Source:

Both formulas utilize a combination of fats, including palm oil, high oleic sunflower oil, soy oil, and a single-cell oil blend that includes DHA and ARA. These fatty acids are crucial for brain and eye development in infants, ensuring that they receive comprehensive nutrition.

Extra Features:

Enfamil Neuropro Gentlease stands out with the inclusion of extra features, specifically MFGM (Milk Fat Globule Membrane) and HuMO6 (Immune & Gentle Blend).

  1. MFGM (Milk Fat Globule Membrane): MFGM is a natural component found in breast milk. It contains essential proteins and lipids that play a vital role in brain development. The presence of MFGM in Neuropro Gentlease is particularly important because it contributes to cognitive development, helping infants reach their developmental milestones. MFGM has been linked to improved cognitive outcomes in infants, making it a noteworthy addition.
  2. HuMO6 (Immune & Gentle Blend): The HuMO6 blend is designed to support both the immune system and digestive comfort in infants. It contains 2′-FL HMO, Vit C & E, Selenium, partially hydrolyzed protein, and reduced lactose. This blend enhances the overall immune health of the baby, helping them fend off infections and illnesses more effectively. Additionally, it aids in gentle digestion, reducing the likelihood of gastrointestinal discomfort.


Enfamil Gentlease, although effective at addressing common digestive issues, does not contain added prebiotics. Prebiotics like 2′-FL HMO are known to support the development of a healthy gut microbiome, enhance digestion, and boost the immune system. Enfamil Neuropro Gentlease includes 2′-FL HMO, an important component mimicking the natural prebiotics found in breast milk.


The GMO-free certification of Enfamil Neuropro Gentlease is an appealing feature for parents who prioritize non-genetically modified ingredients. This certification signifies that the ingredients used in the formula have not been genetically altered, providing a higher level of transparency in sourcing.

On the other hand, Enfamil Gentlease is not branded as GMO-Free which means that it may have some GMO ingredients.

Generic Brands:

Both formulas have generic or store-brand equivalents available, which can offer significant cost savings without compromising on essential nutrition. This availability allows parents to find budget-friendly alternatives while ensuring their child’s nutritional needs are met. Read Best 6 Generic Brands of Enfamil NeuroPro Gentlease.

Source of ARA and DHA:

ARA and DHA are key fatty acids necessary for brain and eye development. The consistent use of Mortierella alpina and Schizochytrium sp. oils in both formulas assures parents that their infant receives these vital nutrients.

Nutrients Comparison:

enfamil gentlease vs neuropro gentlease in terms of macronutrients and vitamins


  • Protein (g): Enfamil Gentlease and Enfamil Neuropro Gentlease both provide 2.3 grams of protein per 100 calories. This balanced protein content is suitable for infant growth and development.
  • Fat (g): Both formulas offer 5.3 grams of fat per 100 calories, providing essential fatty acids for brain and eye development.
  • Carbohydrate (g): Both formulas contain 10.8 grams of carbohydrates per 100 calories, which is primarily derived from a combination of lactose and corn syrup solids, ensuring a balance of energy sources.


  • Vitamin A (IU): Both formulas provide 300 IU of Vitamin A per 100 calories, which is essential for vision and immune system support.
  • Vitamin D (IU): Enfamil Gentlease offers 60 IU of Vitamin D, while Enfamil Neuropro Gentlease powder contains 70 IU and ready-to-use contains 65 IU. Vitamin D is crucial for calcium absorption and bone health.
  • Vitamin E (IU): Both formulas supply 2 IU of Vitamin E per 100 calories, which acts as an antioxidant and supports overall health.
  • Vitamin K (mcg): Both formulas contain 9 mcg of Vitamin K, which is vital for blood clotting and bone health.
  • Vitamin B1 (mcg): Enfamil Gentlease and Enfamil Neuropro Gentlease provide 80 mcg of Vitamin B1 per 100 calories, which is essential for energy metabolism.
  • Vitamin B2 (mcg): Both formulas offer 140 mcg of Vitamin B2, also known as riboflavin, which plays a role in various metabolic processes.
  • Vitamin B6 (mcg): Enfamil Gentlease and Enfamil Neuropro Gentlease contain 60 mcg of Vitamin B6, supporting brain development and function.
  • Vitamin B12 (mcg): Both formulas provide 0.3 mcg of Vitamin B12, contributing to the formation of red blood cells and nerve health.
  • Niacin (mcg): Enfamil Gentlease and Enfamil Neuropro Gentlease contain 1000 mcg of niacin per 100 calories, supporting various bodily functions.
  • Folic Acid (mcg): Both formulas supply 16 mcg of folic acid, which is vital for cell division and the development of the neural tube.
  • Pantothenic Acid (mcg): Enfamil Gentlease and Enfamil Neuropro Gentlease offer 500 mcg of pantothenic acid, which is involved in energy production and fatty acid synthesis.
  • Biotin (mcg): Both formulas contain 3 mcg of biotin, which is important for healthy skin, hair, and nails.
  • Vitamin C (mg): Both formulas provide 12 mg of Vitamin C, supporting the immune system and overall health.

Other Nutrients:

  • Choline (mg): Both formulas supply 24 mg of choline, which is essential for brain development and overall health.
  • Inositol (mg): Enfamil Gentlease contains 6 mg of inositol, while Enfamil Neuropro Gentlease contains a higher amount, 24 mg. Inositol plays a role in various cellular processes and brain function.

The key difference here is that Enfamil Neuropro Gentlease has more Vitamin D and Inositol than Enfamil Gentlease.


enfamil gentlease vs neuropro gentlease in terms of minerals
  • Calcium (mg): Both Enfamil Gentlease and Enfamil Neuropro Gentlease provide 82 mg of calcium per serving. Calcium is essential for the development of strong bones and teeth.
  • Phosphorus (mg): Both formulas contain 46 mg of phosphorus. Phosphorus is crucial for bone health and is often found in conjunction with calcium.
  • Magnesium (mg): Both formulas supply 8 mg of magnesium. Magnesium is involved in various bodily processes and supports muscle and nerve function.
  • Iron (mg): both formulas contain 1.8 mg of iron. Iron is essential for the formation of red blood cells and oxygen transport in the body.
  • Zinc (mg): Both formulas provide 1 mg of zinc. Zinc plays a role in immune function, wound healing, and overall growth and development.
  • Manganese (mcg): Both formulas offer 15 mcg of manganese. Manganese is a trace mineral that supports bone health and antioxidant function.
  • Copper (mcg): both formulas contain 75 mcg of copper. Copper is necessary for various enzymatic reactions and the formation of red blood cells.
  • Iodine (mcg): Both formulas supply 15 mcg of iodine. Iodine is crucial for thyroid function and the production of thyroid hormones.
  • Selenium (mcg): Both formulas contain 2.8 mcg of selenium. Selenium is an important antioxidant mineral that supports overall health.
  • Sodium (mg): Both formulas provide 40 mg of sodium. Sodium is involved in maintaining fluid balance and nerve function in the body.
  • Potassium (mg): Both formulas contain 108 mg of potassium. Potassium is essential for maintaining proper heart and muscle function.
  • Chloride (mg): Both Enfamil Gentlease and Enfamil Neuropro Gentlease offer 63 mg of chloride. Chloride is important for maintaining fluid balance and the body’s acid-base equilibrium.

when it comes to minerals, Enfamil Gentlease and Enfamil Neuropro Gentlease have nearly identical mineral content per serving. Both formulas provide a well-balanced mineral profile to support the overall health and development of infants.

Price Comparison:

12.4 oz
Buy 12.4 oz
19.5 oz
$1,94 /oz
Buy 19.5 oz
19.9 oz
Buy 19.9 oz
27.4 oz
$1,90 /oz
Buy 27.4 oz
27.7 oz
Buy 27.7 oz
30,4 oz
$1,79 /oz
Buy 30.4 oz
2 fl oz
83,2 ¢/ fl oz
32 fl oz
31,0 ¢/fl oz
Buy 32 fl oz
4.8 of 5.0
7432 reviews
4.8 of 5.0
7096 reviews

While both formulas offer various sizes, Enfamil Neuropro Gentlease tends to be pricier per ounce than Enfamil Gentlease in most cases. This price discrepancy makes Neuropro Gentlease the slightly more expensive option, despite both formulas providing multiple size choices.


When comparing the ready-to-feed options, Enfamil Gentlease does not provide a ready-to-feed version, limiting the convenience for parents seeking pre-mixed formula. In contrast, Enfamil Neuropro Gentlease offers both 2 fl oz and 32 fl oz ready-to-feed options, catering to the varying needs of parents. The 2 fl oz size is convenient for on-the-go feedings, ensuring that parents can quickly and easily provide their infants with nourishment without the need for mixing. Meanwhile, the 32 fl oz option is a practical choice for those who prefer to buy larger quantities of pre-mixed formula, making it ideal for families with higher feeding demands.


Both Enfamil Gentlease and Enfamil Neuropro Gentlease boast impressive ratings, with a score of 4.8 out of 5.0. These high ratings reflect the overall satisfaction of users with both formulas, indicating that they are well-received by parents.

Can You Mix Enfamil Gentlease and Neuropro Gentlease?

Yes, you can mix Enfamil Gentlease and Enfamil Neuropro Gentlease. These formulas share the same protein, fat, and carbohydrate sources, making them compatible for combination if needed. Mixing them in equal proportions can provide a balanced blend of nutrition for your baby.

How to Switch Between Enfamil Gentlease and Neuropro Gentlease?

Switching between Enfamil Gentlease and Enfamil Neuropro Gentlease can be done gradually or using a “cold turkey” approach. Here’s how to do it:

Gradual Transition:

  1. Consult Your Pediatrician: Before making any changes, consult your pediatrician to ensure the switch is appropriate for your baby’s specific needs.
  2. Start Mixing: Begin by mixing the two formulas in a 25% Neuropro Gentlease to 75% Gentlease ratio. This means that for every four ounces of formula, use one ounce of Neuropro Gentlease and three ounces of Gentlease.
  3. Observe Your Baby: Watch for any adverse reactions or changes in your baby’s feeding patterns or digestive health during this transition phase.
  4. Adjust the Ratio: After a few days or a week, depending on your baby’s tolerance, you can gradually increase the proportion of Neuropro Gentlease while decreasing the amount of Gentlease. Move to a 50-50 ratio and then eventually to a 75% Neuropro Gentlease to 25% Gentlease ratio before making the complete switch.
  5. Full Transition: Once your baby has successfully adjusted to the new formula, you can switch entirely to Enfamil Neuropro Gentlease.

Cold Turkey Switch:

  1. Consult Your Pediatrician: Always consult your pediatrician before making a cold turkey switch to ensure it’s appropriate for your baby.
  2. Immediate Change: With the cold turkey method, you switch directly from one formula to the other. Stop using Enfamil Gentlease and begin using Enfamil Neuropro Gentlease for all feedings.
  3. Monitor Your Baby: Keep a close eye on your baby for any signs of discomfort or intolerance. Babies may experience a more abrupt adjustment period when using the cold turkey method.
  4. Give It Time: Allow your baby a few days to a week to adapt to the new formula. Some babies might transition seamlessly, while others may experience temporary digestive changes.
  5. Contact Your Pediatrician if Needed: If your baby has difficulty adjusting or shows any concerning symptoms, consult your pediatrician for guidance.

Your choice of method for transitioning between formulas may be influenced by your baby’s unique circumstances. In some situations, if your primary formula isn’t readily available, a cold turkey switch becomes necessary, and this approach can be safe and viable.




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