Enfamil Neuropro Gentlease Vs Neuropro Care: What’s The Difference?

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What is The Difference Between Them?

Enfamil Neuropro Gentlease is tailored for infants experiencing fussiness, gas, and spit-up, featuring partially hydrolyzed protein, 2′-FL HMO prebiotic, MFGM, and HuMO 6 immune blend whereas Neuropro Care is a standard formula ideal for healthy babies, offering triple prebiotics, MFGM, and balanced nutrition, making it a suitable choice for infants without specific health concerns.

The choice between them depends on your baby’s health condition, if your baby has fussiness, gas, spit-up, or crying issues, Neuropro Gentlease will be the best choice. If not, Neuropro Care is a good choice in the case of a normal baby because it has 2 FL HMO, and MFGM features at a cheaper price.

Mom’s Reviews Comparison:

Enfamil Neuropro Gentlease :

Enfamil Neuropro Gentlease has garnered positive reviews from numerous moms who appreciate its efficacy in addressing gas and spit-up issues in infants. It is widely recognized for being gentle on babies’ stomachs, reducing fussiness, and alleviating symptoms of colic. Some moms have reported an improvement in their baby’s sleep patterns, attributing it to the formula’s soothing effects.

Despite its benefits, some moms criticize it for its relatively higher cost compared to other formula options. Negative remarks have also been made regarding the taste and smell, and concerns have been raised about potential constipation or gas issues in some infants.

Related: Enfamil Gentlease Vs Enfamil Neuropro Gentlease

Enfamil Neuropro Care:

On the positive side, Enfamil Neuropro Care is praised for its affordability, making it an attractive option for budget-conscious parents. Users find it easy to prepare, adding to the convenience for busy parents, and the formula receives positive feedback for its gentle impact on digestion.

However, it has faced criticism from some parents regarding a perceived price increase. Negative feedback has also been expressed about difficulties transitioning to this formula, and certain users have encountered challenges due to limited in-store availability, posing inconvenience for some parents seeking this specific product.

Ingredients Comparison:

Age Range:

Designed to meet the nutritional needs of infants within the 0-12 month age range, both formulas cater to the critical developmental stages of early infancy.

Protein Source:

Enfamil Neuropro Care derives its protein from a combination of nonfat milk and whey protein concentrate, providing a well-balanced source for optimal growth and development. On the other hand, Neuropro Gentlease incorporates a partially hydrolyzed protein blend, featuring nonfat milk and soy-based whey concentrate in a 60:40 ratio. This composition aims to ease digestion, particularly beneficial for infants with sensitivities.

Carbohydrate Source:

In terms of carbohydrate composition, Neuropro Care relies solely on 100% lactose, mirroring the natural sugars found in breast milk to enhance digestibility. In contrast, Neuropro Gentlease combines 20% lactose with 80% corn syrup solids. This alternative carbohydrate profile is formulated to address the needs of infants prone to fussiness and digestive discomfort.

Related: Enfamil Neuropro Vs. Neuropro Care: What is The Difference?

Fat Source:

Both formulas share a common fat source profile, including Palm Oil, High Oleic Sunflower Oil, Soy Oil, and Coconut Oil. These fats are essential for supporting brain development and providing a well-rounded source of energy for growing infants.


Incorporating essential fatty acids, both Neuropro Care and Neuropro Gentlease feature DHA (Docosahexaenoic Acid) and ARA (Arachidonic Acid). These crucial components are derived from Schizochytrium sp. oil and Mortierella alpina oil, respectively, contributing to cognitive and visual development.

Extra Features:

Neuropro Care introduces additional components with Milk Fat Globule Membrane (MFGM), promoting brain health. In comparison, Neuropro Gentlease not only includes MFGM but also incorporates HuMO6 (Immune & Gentle Blend) to provide immune support and alleviate digestive discomfort.

Milk Fat Globule Membrane (MFGM). This complex structure, derived from the fat globules in milk, contains various bioactive compounds like proteins, lipids, and glycoproteins. MFGM is recognized for its potential role in promoting brain health and cognitive development.

HuMO6 is a carefully crafted combination that encompasses several key components. The blend features 2’-FL HMO, a prebiotic that supports the development of a healthy gut microbiome, fostering a conducive environment for beneficial bacteria. Additionally, HuMO6 incorporates essential vitamins and minerals such as Vitamin C & E, and Selenium, contributing to immune system support and overall health.

The partially hydrolyzed protein in this blend facilitates easier digestion, addressing the specific needs of infants prone to fussiness. Furthermore, the reduction in lactose content adds to the formula’s gentleness on the digestive system, making it a suitable choice for infants with sensitivities.


While both formulas include 2′-FL HMO as a prebiotic, Neuropro Care complements it with Polydextrose and Galactooligosaccharides for a comprehensive blend supporting a balanced gut microbiome.

2′-FL HMO, a human milk oligosaccharide, is structurally similar to those found in breast milk and serves as a nourishing substrate for beneficial gut bacteria. Polydextrose and Galactooligosaccharides further contribute to the prebiotic blend, fostering a favorable environment for the growth and activity of probiotics in the infant’s gut.


A shared commitment to natural and safe ingredients is evident in both formulas, as both Neuropro Care and Neuropro Gentlease proudly assert their GMO-Free status.

Generic Brands:

Neuropro Care is associated with 9 generic brands, ensuring accessibility and affordability for parents seeking alternatives. Neuropro Gentlease, with ties to 6 generic brands, provides cost-effective options catering to diverse parental preferences.

Nutrients Comparison:

Protein, Fat, and Carbohydrates:

In terms of protein content, Neuropro Care offers 2.1g per 100 calories, while Neuropro Gentlease slightly surpasses this with 2.3g per 100 calories. This variance reflects the distinctive protein composition of Gentlease, incorporating partially hydrolyzed nonfat milk and soy-based whey concentrate, catering to infants with specific digestive sensitivities.

Moving on to fat, both formulas share an identical content of 5.3g per 100 calories, sourced from Palm Oil, High Oleic Sunflower Oil, Soy Oil, and Coconut Oil, delivering essential fatty acids crucial for the development of the infant’s brain and eyes.

Regarding carbohydrates, Neuropro Care presents 11.3g per 100 calories, relying solely on 100% lactose as its carbohydrate source. In contrast, Neuropro Gentlease provides a slightly lower carbohydrate content of 10.8g per 100 calories, incorporating a blend of 20% lactose and 80% corn syrup solids. This unique composition aims to offer an alternative for infants prone to fussiness, providing a gentler option for their developing digestive systems.


In terms of vitamins, both formulas have the same vitamin levels except for Vitamin D., Neuropro Care provides a slightly higher level of 75 IU compared to Neuropro Gentlease’s 70 IU.

Vitamin D plays a crucial role in calcium absorption and bone health. While both formulas meet the essential vitamin requirements for infants, the variance might be considered by parents who prioritize specific vitamin concentrations for their infants’ bone development.


In examining the mineral content per 100 calories (5 fl oz) of both formulas, the detailed comparison reveals subtle differences in concentrations, underscoring the formulas’ commitment to providing essential minerals crucial for infant development.

Calcium and Phosphorus:

  • Both formulas offer crucial minerals for bone health, with Neuropro Care providing 78 mg of calcium and 43 mg of phosphorus, while Neuropro Gentlease offers slightly higher concentrations at 82 mg of calcium and 46 mg of phosphorus per serving.


  • Both formulas supply an equal amount of magnesium at 8 mg per 100 calories, contributing to muscle and nerve function.


  • Neuropro Care and Neuropro Gentlease share an identical iron content of 1.8 mg per serving, vital for the formation of hemoglobin and the prevention of iron deficiency.

Zinc, Manganese, Copper, Iodine, and Selenium:

  • These trace minerals are consistent in both formulas, each offering 1 mg of zinc, 15 mcg of manganese, 75 mcg of copper, 15 mcg of iodine, and 2.8 mcg of selenium per 100 calories. These minerals play essential roles in various physiological functions, including immune support, enzyme activity, and thyroid function.


  • A notable difference arises in sodium content, with Neuropro Care providing 27 mg, while Neuropro Gentlease has a slightly higher concentration at 40 mg per 100 calories. Sodium is crucial for maintaining fluid balance and nerve function.

Potassium and Chloride:

  • Both formulas supply an equal amount of potassium (108 mg) and chloride (63 mg) per serving, contributing to electrolyte balance and cellular function.

Price Comparison:

When assessing the cost of Enfamil Neuropro Gentlease and Neuropro Care, the detailed comparison across various sizes and formats provides insights into the affordability and value for parents:

Enfamil Neuropro Gentlease:

  • 19.5 oz: Priced at $37.84, equivalent to $1.94 per ounce.
  • 27.4 oz: Priced at $52.00, translating to $1.90 per ounce.
  • 30.4 oz: Available for $54.40, with a cost of $1.79 per ounce.
  • 2 fl oz (Ready-to-feed): Priced at $1.66, amounting to 83.2 cents per fluid ounce.
  • 32 fl oz (Ready-to-feed): Priced at $12.49, at a rate of 39.0 cents per fluid ounce.

Enfamil Neuropro Care:

  • 20.7 oz: Priced at $27.99, equivalent to $1.35 per ounce.

Rating: Both formulas boast an impressive rating of 4.8 out of 5.0, with Neuropro Gentlease backed by 7,432 reviews and Neuropro Care with 5,355 reviews.

Ready-to-feed: Neuropro Gentlease is available in a ready-to-feed format, providing convenience, while Neuropro Care does not offer this option.

In summary, while the Neuropro Care formula tends to be more cost-effective per ounce, the Neuropro Gentlease formula offers multiple sizes and a ready-to-feed option for added convenience. The high ratings for both formulas underscore their popularity and positive reception among parents.

Enfamil Neuropro Gentlease is relatively more expensive than Neuropro Care due to its specialized formulation catering to infants with sensitivities. The unique protein composition, including partially hydrolyzed nonfat milk and soy-based whey concentrate, and additional features like HuMO6, contribute to its higher production costs.

Where to Buy?

Neuropro GentleaseNeuropro Care
Buy 19.5 oz

Buy 27.4 oz

Buy 30.4 oz

Buy 32 fl oz
Buy 27.99 oz

Switching From Neuropro Care to Neuropro Gentlease:

Switching from Enfamil Neuropro Care to Neuropro Gentlease could be done gradually to help your baby adapt to the new formula. Here’s a general guideline:

  1. Consult with Pediatrician: Before making any changes to your baby’s formula, it’s crucial to consult with your pediatrician. They can provide personalized advice based on your baby’s health and specific needs.
  2. Gradual Transition: Start by gradually introducing Neuropro Gentlease alongside the current Neuropro Care formula. Mix the two formulas in different ratios over several days to allow your baby’s digestive system to adjust.
    • Day 1-2: 75% Neuropro Care, 25% Neuropro Gentlease
    • Day 3-4: 50% Neuropro Care, 50% Neuropro Gentlease
    • Day 5-6: 25% Neuropro Care, 75% Neuropro Gentlease
    • Day 7 onward: 100% Neuropro Gentlease
  3. Observe Your Baby: Watch for any signs of discomfort, changes in stool patterns, or allergic reactions during the transition. If you notice any unusual symptoms, contact your pediatrician.
  4. Monitor Feeding Patterns: Keep an eye on your baby’s feeding habits, including intake and satisfaction. If your baby seems content and experiences no adverse reactions, it’s a positive sign of successful transitioning.
  5. Stay Consistent: Once the transition is complete and your baby is comfortably adjusted to Neuropro Gentlease, continue with this formula unless advised otherwise by your pediatrician.

Remember, every baby is unique, and their response to formula changes may vary. It’s crucial to consult with your healthcare provider throughout the process to ensure a smooth and healthy transition for your little one.


In summary, comparing Enfamil Neuropro Gentlease and Neuropro Care brings to light significant differences to accommodate various parental and infant requirements. Neuropro Gentlease, designed for sensitive babies, introduces unique features like partially hydrolyzed protein and HuMO6, albeit at a slightly higher cost. Conversely, Neuropro Care, with its standard composition and budget-friendly pricing, appeals to parents seeking reliability without compromising on quality.

Thus, the choice between them depends on your baby’s health condition, if your baby has fussiness, gas, spit-up, or crying issues, Neuropro Gentlease will be the best choice. If not, Neuropro Care is a good choice in the case of a normal baby because it has 2 FL HMO, and MFGM features at a cheaper price.

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