Enfamil Neuropro vs All Similac Formulas : Full Comparison

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Enfamil Neuropro Infant is a standard milk-based formula designed for full-term infants 0–12 months, made from nonfat milk and whey protein concentrate (source of MFGM) and 100% lactose. Also, it has a triple blend of prebiotics (GOS and PDX plus 2’-FL HMO) to help the growth of probiotics so they keep the digestive and immune systems healthy. Furthermore, the Neuropro Infant formula has brain-building DHA and an inositol level like in breastmilk.

In this article, we will see a complete comparison between Enfamil Neuropro and all Similac formulas to help you choose the right one for your LO.

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Enfamil Neuropro Infant vs Similac Pro Advance:

Enfamil Neuropro Infant vs Similac Pro Advance

The difference between Enfamil Neuropro and Similac Pro Advance is in the fat source and whey to casein ratio; Similac Pro Advance doesn’t use palm oil to ensure the absorption of calcium and fat by the baby’s body. Also, Similac Pro Advance has a whey to casein ratio of 48:52 whereas the Neuropro formula has a ratio of 60:40. Moreover, Enfamil Neuropro has a triple prebiotic immune Blend (GOS, PDX, 2’-FL HMO) whereas Similac Pro Advance has two prebiotics.

Whey and casein are derived from cow’s milk protein and they differ in digestion speed, whey is digested quickly contrary to casein.

Those differences aren’t a big concern since both formulas are using the same protein and carbohydrate source. Thus, the best alternative formula in the Similac brand to Enfamil Neuropro is Similac Pro Advance.

Extra Features:

Enfamil Neuropro has introduced the MFGM components whey protein concentrate, this MFGM (milk fat globule membrane) has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).

Whereas Similac Pro Advance added the OptiGRO feature which is a blend of DHA, Lutein, and Vitamin E. This blend helps promote eye health and brain development, and to support the development of cells.

Moreover, Enfamil Neuropro and Similac Pro Advance have both 9 generic brands. Check the 9 generic brands of the Neuropro formula and the 9 generic brands of the Pro Advance formula.

This table shows a full comparison between Enfamil Neuropro and Similac Pro Advance :

Enfamil NeuroproSimilac Pro Advance
Protein sourceNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio60:4048:52
Carbohydrate source100% Lactose100% Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Prebiotics– 2′-FL HMO
– Galactooligosaccharides
– Polydextrose
2′-FL HMO
Short-chain Fructooligosaccharides
Extra FeaturesMFGMOptiGRO
Protein (g)2.1 /100 Cal2.07 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal78 /100 Cal
Phosphorus (mg)43 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)27 /100 Cal24 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilSchizochytrium Sp. Oil
Size and Price20.7 oz
29.98 $
1.45 /oz
30.8 oz
36.96 $
1.20 /oz
Rating4.8 of 5.0
6852 reviews
4.5 of 5.0
780 reviews
Where to Buy?
Buy HERE

Buy HERE
Enfamil Neuropro infant vs Similac Pro Advance

Enfamil Neuropro Infant vs Similac Advance:

Enfamil Neuropro Infant vs Similac Advance

The difference between Enfamil Neuropro and Similac Advance is in the prebiotics, fat source, and whey to casein ratio; Similac Advance has one prebiotic (Short-chain Fructooligosaccharides) while Enfamil Neuropro has three prebiotics (2′-FL HMO – Galactooligosaccharides – Polydextrose). Moreover, Similac Advance doesn’t use palm oil among fat sources. Also, Similac Pro Advance has a whey to casein ratio of 48:52 whereas the Neuropro formula has a ratio of 60:40.

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

Prebiotics will promote the growth of beneficial bacteria (probiotics), and a well-fed probiotic will help with digestive health.

Extra Features:

Enfamil Neuropro has introduced the MFGM components whey protein concentrate, this MFGM (milk fat globule membrane) has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).

Whereas Similac Pro Advance added the OptiGRO feature which is a blend of DHA, Lutein, and Vitamin E. This blend helps promote eye health and brain development, and to support the development of cells.

This table shows a full comparison between Enfamil Neuropro and Similac Advance :

Enfamil NeuroproSimilac Advance
Protein sourceNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio60:4048:52
Carbohydrate source100% Lactose100% Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Prebiotics– 2′-FL HMO
– Galactooligosaccharides
– Polydextrose
Short-chain Fructooligosaccharides
Protein (g)2.1 /100 Cal2.07 /100 Cal
Fat (g)5.3 /100 Cal5.6 /100 Cal
Carbohydrate (g)11.3 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300
Vitamin D (IU)75 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal78 /100 Cal
Phosphorus (mg)43 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)27 /100 Cal24 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price20.7 oz
29.98 $
1.45 /oz
12.4 oz
17.46 $
1.41/oz
Ready-to-use versionYesYes
Rating4.8 of 5.0
6852 reviews
4.7 of 5.0
1472 reviews
Where to Buy?
Buy HERE

Buy HERE
Enfamil Neuropro infant vs Similac Advance

Enfamil Neuropro Infant vs Similac Sensitive:

Enfamil Neuropro Infant vs Similac Sensitive

The difference between Similac Sensitive and Enfamil Neuropro is that Similac Sensitive is designed for fussiness & gas due to lactose sensitivity by making it 99% lactose-free while Enfamil Neuropro is a standard formula for babies with no health issues. Thus there are big differences between these two formulas:

Protein:

Enfamil Neuropro has nonfat milk and whey protein concentrate (a source of MFGM) while Similac Sensitive has the milk protein isolate. The ratio of whey to casein is also different, the Neuropro formula has a ratio of 60:40 whereas Similac Sensitive has a ratio of 18:82.

Nonfat milk is cow’s milk where the fat has been removed, and the whey protein concentrate is made from 80% of whey, the rest is carbohydrates and fats.

The milk protein isolate is extracted from skim milk powder and has been filtered to eliminate most of the minerals and the lactose because this last is the reason for sensitivity issues.

Carbohydrate:

Similac Sensitive is 99% lactose-free, and the rest of the carbohydrate sources are from corn syrup and sugar (sucrose) while Enfamil Neuropro is sugar-free and all carbohydrate source is from lactose. Thus, Similac Sensitive is the best choice for babies with sensitive tummies to lactose.

Fat Source:

Both formulas have the same fate sources except that Similac Sensitive doesn’t use palm oil which is good because it may reduce fat and calcium absorption. However, if the baby is thriving and doesn’t have hard stool then it’s not a concern.

Prebiotics:

Enfamil Neuropro has a triple blend of prebiotics, which may help soften stools, whereas Similac Sensitive has one prebiotic.

Nutrients, Vitamins, and Minerals:

In terms of nutrients and vitamins level, we notice that Enfamil Neuropro gives more levels than Similac Sensitive. However, the Similac brand excels in terms of mineral levels.

Related: Best 7 Generic Brands For Similac Sensitive

This table shows a full comparison between Enfamil Neuropro and Similac Sensitive :

Enfamil NeuroproSimilac Sensitive
Protein sourceNonfat Milk
Whey Protein Concentrate
Milk Protein Isolate
Whey to Casein Ratio60:4018:82
Carbohydrate source100% Lactose 1% Lactose
Corn Syrup
Sugar
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Prebiotics– 2′-FL HMO
– Galactooligosaccharides
– Polydextrose
Short-chain Fructooligosaccharides
Extra FeaturesMFGMOptiGRO
Protein (g)2.1 /100 Cal2.1 /100 Cal
Fat (g)5.3 /100 Cal5.4 /100 Cal
Carbohydrate (g)11.3 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300
Vitamin D (IU)75 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal84 /100 Cal
Phosphorus (mg)43 /100 Cal56 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)27 /100 Cal30 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price20.7 oz
29.98 $
1.45 /oz
12.5 oz
17.46 $
1.40/oz
Ready-to-use versionYesYes
Rating4.8 of 5.0
6852 reviews
4.5 of 5.0
1482 reviews
Where to Buy?
Buy HERE

Buy HERE
Enfamil Neuropro infant vs Similac Sensitive

Enfamil Neuropro Infant vs Similac Pro Sensitive:

Enfamil Neuropro Infant vs Similac Pro Sensitive

The difference between Similac Pro Sensitive and Enfamil Neuropro is that Similac Pro Sensitive is designed for infants with symptoms of fussiness, gassiness, bloating, and frequent loose stools by reducing lactose by 99% whereas Enfamil Neuropro is a standard formula for babies with no health issues. Thus there are big differences between these two formulas:

Protein:

Enfamil Neuropro has nonfat milk and whey protein concentrate (a source of MFGM) while Similac Pro Sensitive has the milk protein isolate. The ratio of whey to casein is also different, the Neuropro formula has a ratio of 60:40 whereas the Pro Sensitive formula has a ratio of 18:82.

Carbohydrate:

Similac Pro Sensitive is 99% lactose-free, and the rest of the carbohydrate sources are from corn syrup and sugar (sucrose) while Enfamil Neuropro is sugar-free and all carbohydrate source is from lactose. Thus, Similac Pro Sensitive is the best choice for babies with sensitive tummies to lactose.

Related: Best 7 Generic Brands For Similac Pro Sensitive

Fat Source:

Both formulas have the same fate sources except that Similac Pro Sensitive is palm oil-free which is good because it may reduce fat and calcium absorption. However, if the baby is thriving and doesn’t have hard stool then it’s not a concern.

Prebiotics:

Enfamil Neuropro has a triple blend of prebiotics, which may help soften stools, whereas Similac Pro Sensitive has two prebiotics.

Nutrients, Vitamins, and Minerals:

In terms of nutrients and vitamins level, we notice that Enfamil Neuropro gives more levels than Similac Pro Sensitive. However, the Similac brand excels in terms of mineral levels.

This table shows a full comparison between Enfamil Neuropro and Similac Pro Sensitive :

Enfamil NeuroproSimilac Pro Sensitive
Protein sourceNonfat Milk
Whey Protein Concentrate
Milk Protein Isolate
Whey to Casein Ratio60:4018:82
Carbohydrate source100% Lactose 1% Lactose
99% Corn Syrup
Sugar
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Prebiotics– 2′-FL HMO
– Galactooligosaccharides
– Polydextrose
2′-FL HMO
Short-chain Fructooligosaccharides
Protein (g)2.1 /100 Cal2.1 /100 Cal
Fat (g)5.3 /100 Cal5.4 /100 Cal
Carbohydrate (g)11.3 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300
Vitamin D (IU)75 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal84 /100 Cal
Phosphorus (mg)43 /100 Cal56 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)27 /100 Cal30 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price20.7 oz
29.98 $
1.45 /oz
29.8 oz
36.96 $
1.24 /oz
Ready-to-use versionYesYes
Rating4.8 of 5.0
6852 reviews
4.3 of 5.0
895 reviews
Where to Buy?
Buy HERE

Buy HERE
Enfamil Neuropro infant vs Similac Pro Sensitive

Enfamil Neuropro Infant vs Similac Total Comfort:

Enfamil Neuropro Infant vs Similac Total Comfort

The difference between Similac Total Comfort and Enfamil Neuropro is that the Total Comfort formula has a partially hydrolyzed whey protein and it’s a 99% lactose-free formula designed for babies with lactose sensitivity and who have bad reactions to standard milk-based formulas whereas Enfamil Neuropro is a standard milk-based formula designed for babies with no health issues.

Moreover, Similac Total Comfort contains no palm oil and has nutrients and mineral levels more than Enfamil Neuropro formula while this last is sugar-free and contains a triple blend prebiotic. Also, it has vitamin levels more than Similac Total Comfort.

Furthermore, Similac doesn’t have a ready-to-use version of the Total Comfort formula.

Related: Best 6 Generic Similac Total Comfort

To be a partially hydrolyzed formula, Similac Total Comfort has chopped the protein a little bit in size to be like that found in breastmilk.

Image source: Nestle Health Science

This table shows a full comparison between Enfamil Neuropro and Similac Total Comfort :

Enfamil NeuroproSimilac Total Comfort
Protein sourceNonfat Milk
Whey Protein Concentrate
Partially hydrolyzed whey
protein
Whey to Casein Ratio60:40100% whey
Carbohydrate source100% Lactose1% Lactose
Corn Maltodextrin
Sugar
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Prebiotics– 2′-FL HMO
– Galactooligosaccharides
– Polydextrose
Short-chain Fructooligosaccharides
Protein (g)2.1 /100 Cal2.32 /100 Cal
Fat (g)5.3 /100 Cal5.4 /100 Cal
Carbohydrate (g)11.3 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)75 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal105 /100 Cal
Phosphorus (mg)43 /100 Cal75 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)27 /100 Cal44 /100 Cal
Zinc (mg)1 /100 Cal0.75 /100 Cal
Manganese (mcg)15 /100 Cal5 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price20.7 oz
29.98 $
1.45 /oz
12.6 oz
17.99 $
1.43/oz
Ready-to-use versionYesNo
Rating4.8 of 5.0
6852 reviews
4.5 of 5.0
311 reviews
Where to Buy?
Buy HERE

Buy HERE
Enfamil Neuropro infant vs Similac Total Comfort

Enfamil Neuropro Infant vs Similac Pro Total Comfort:

Enfamil Neuropro Infant vs Similac Pro Total Comfort

The difference between Similac Pro Total Comfort and Enfamil Neuropro is that the Pro Total Comfort formula has a partially hydrolyzed whey protein and it’s a 99% lactose-free formula designed for babies with lactose sensitivity and who have bad reactions to standard milk-based formulas whereas Enfamil Neuropro is a standard milk-based formula that contains the intact protein designed for babies with no health issues.

Furthermore, Similac Pro Total Comfort contains no palm oil and has nutrients and mineral levels more than Enfamil Neuropro formula while this last is sugar-free and contains a triple blend prebiotic. Also, it has vitamin levels more than Similac Pro Total Comfort.

Related: Best 6 Generic Similac Pro Total Comfort

To be a partially hydrolyzed formula, Similac Pro Total Comfort has chopped the protein a little bit in size to be like that found in breastmilk.

This table shows a full comparison between Enfamil Neuropro and Similac Pro Total Comfort :

Enfamil NeuroproSimilac Pro Total Comfort
Protein sourceNonfat Milk
Whey Protein Concentrate
Partially hydrolyzed whey
protein
Whey to Casein Ratio60:40100% whey
Carbohydrate source100% Lactose1% Lactose
Corn Maltodextrin
Sugar
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Prebiotics– 2′-FL HMO
– Galactooligosaccharides
– Polydextrose
2′-FL HMO
Short-chain Fructooligosaccharides
Protein (g)2.1 /100 Cal2.32 /100 Cal
Fat (g)5.3 /100 Cal5.4 /100 Cal
Carbohydrate (g)11.3 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)75 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal105 /100 Cal
Phosphorus (mg)43 /100 Cal75 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)27 /100 Cal44 /100 Cal
Zinc (mg)1 /100 Cal0.75 /100 Cal
Manganese (mcg)15 /100 Cal5 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price20.7 oz
29.98 $
1.45 /oz
29.8 oz
36.96 $
1.24 /oz
Ready-to-use versionYesYes
Rating4.8 of 5.0
6852 reviews
4.0 of 5.0
772 reviews
Where to Buy?
Buy HERE

Buy HERE
Enfamil Neuropro infant vs Similac Pro Total Comfort

Enfamil Neuropro Infant vs Similac 360 Total Care:

enfamil neuropro vs similac 360 total care

Similac 360 Total Care and Enfamil Neuropro are both standard milk-based formulas using the same protein but the 360 Total Care formula is palm oil-free and has 5 prebiotics whereas Enfamil Neuropro is rich in nutrients, vitamins, and minerals level. Also, the Neuropro formula is cheaper than Similac 360 Total Care.

This table shows a full comparison between Enfamil Neuropro and Similac 360 Total Care :

Enfamil NeuroproSimilac 360 Total Care
Protein sourceNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio60:40
Carbohydrate source100% Lactose100% Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Prebiotics– 2′-FL HMO
– Galactooligosaccharides
– Polydextrose
2′-FL HMO
Lacto-N-Tetraose
3-Fucosyllactose
6′-Sialyllactose
3′-Sialyllactose
Protein (g)2.1 /100 Cal2.07 /100 Cal
Fat (g)5.3 /100 Cal5.6 /100 Cal
Carbohydrate (g)11.3 /100 Cal10.5 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)75 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal78 /100 Cal
Phosphorus (mg)43 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)27 /100 Cal24 /100 Cal
Zinc (mg)1 /100 Cal0.75 /100 Cal
Manganese (mcg)15 /100 Cal5 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price20.7 oz
29.98 $
1.45 /oz
20.6 oz
35.99 $
1.75 /oz
Ready-to-use versionYesYes
Rating4.8 of 5.0
6852 reviews
4.8 of 5.0
197 reviews
Where to Buy?
Buy HERE

Buy HERE
Enfamil Neuropro infant vs Similac 360 Total Care

Final Thoughts:

Among all these formulas, the best alternative for Enfamil Neuropro Infant in the Similac brand is Similac Advance, Similac pro Advance, and the 360 Total Care formulas because they are all standard milk-based formulas for babies with no health issues and they have the same protein, carbohydrate, and fat sources. In terms of price, Similac Advance and Pro Advance are way cheaper than the 360 Total Care formula. However, this last is the closest one to breastmilk.

The other formulas will be a good substitute for Enfamil Neuropro if your baby has lactose sensitivity problems or negative reactions to standard milk-based formulas.

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