Enfamil Neuropro Infant is a standard milk-based formula designed for full-term infants 0–12 months, made from nonfat milk and whey protein concentrate (source of MFGM) and 100% lactose. Also, it has a triple blend of prebiotics (GOS and PDX plus 2’-FL HMO) to help the growth of probiotics so they keep the digestive and immune systems healthy. Furthermore, the Neuropro Infant formula has brain-building DHA and an inositol level like in breast milk.
In this article, we will see a complete comparison between Enfamil Neuropro and all Similac formulas to help you choose the right one for your LO.
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Enfamil Neuropro Infant vs Similac 360 Total Care:

Similac 360 Total Care and Enfamil Neuropro are both standard milk-based formulas using the same protein but the 360 Total Care formula is palm oil-free and has 5 prebiotics whereas Enfamil Neuropro is rich in nutrients, vitamins, and minerals level. Also, the Neuropro formula is cheaper than Similac 360 Total Care.
Ingredients and Extra Features Comparison :
Enfamil Neuropro and Similac 360 Total Care have the same protein source which is nonfat milk and whey protein concentrate but they have different whey-to-casein ratios as the table below shows, the average ratio in breast milk is 70% to 30% and 80% to 20% in early lactation and 50% to 50% in late lactation.
Furthermore, Similac 360 Total Care doesn’t use palm oil as fat sources to prevent the malabsorption of fat and calcium.
Enfamil Neuropro has triple prebiotics, one of them is an HMO prebiotic (2′-FL) whereas Similac 360 Total Care has five HMO prebiotics to help digestive health.

Nutrients, Vitamins, and Minerals Comparison :
Enfamil Neuropro is enriched with nutrients, minerals, and vitamins more than 360 Total Care as the table below shows. However, it doesn’t mean that the latter formula isn’t giving your baby the nutritional value he needs, Both formulas contribute well in your baby’s growth.

Sizes, Prices, and Rating Comparison :
Both formulas aren’t available for now in small sizes (12.6 oz) in case you want to test the formula. In terms of price, Neuropro is cheaper than 360 Total Care.

Where to Buy?
Enfamil Neuropro Infant | Similac 360 Total Care |
---|---|
Buy 20.7 oz HERE | Buy 20.6 oz HERE |
Buy 28.3 oz HERE | |
Buy 31.4 oz HERE | Buy 30.8 oz HERE |
Buy Ready to use Here | Buy Ready-to-use |
Enfamil Neuropro Infant vs Similac Pro Advance:

The difference between Enfamil Neuropro and Similac Pro Advance is in the fat source and whey to casein ratio; Similac Pro Advance doesn’t use palm oil to ensure the absorption of calcium and fat by the baby’s body. Also, Similac Pro Advance has a whey to casein ratio of 48:52 whereas the Neuropro formula has a ratio of 60:40. Moreover, Enfamil Neuropro has a triple prebiotic immune Blend (GOS, PDX, 2’-FL HMO) whereas Similac Pro Advance has two prebiotics.

Whey and casein are derived from cow’s milk protein and they differ in digestion speed, whey is digested quickly contrary to casein.
Those differences aren’t a big concern since both formulas are using the same protein and carbohydrate source. Thus, the best alternative formula in the Similac brand to Enfamil Neuropro is Similac Pro Advance.

Extra Features:
Enfamil Neuropro has introduced the MFGM components whey protein concentrate, this MFGM (milk fat globule membrane) has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).
Whereas Similac Pro Advance added the OptiGRO feature which is a blend of DHA, Lutein, and Vitamin E. This blend helps promote eye health and brain development, and to support the development of cells.
Moreover, Enfamil Neuropro and Similac Pro Advance have both 9 generic brands. Check the 9 generic brands of the Neuropro formula and the 9 generic brands of the Pro Advance formula.
Nutrients, Vitamins, and Minerals Comparison :

Sizes, Prices, and Rating Comparison :
Similac Pro Advance is available in one powder size for now. In terms of price, the latter formula is cheaper in the powder form whereas Neuropro is cheaper in the RTF form.

Where to Buy?
Enfamil Neuropro Infant | Similac Pro Advance |
---|---|
Buy 20.7 oz HERE | – |
Buy 28.3 oz HERE | – |
Buy 31.4 oz HERE | Buy 30.8 oz HERE |
Buy Ready to use Here | Buy Ready-to-feed |
Enfamil Neuropro Infant vs Similac Advance:

The difference between Enfamil Neuropro and Similac Advance is in the prebiotics, fat source, and whey-to-casein ratio; Similac Advance has one prebiotic (Short-chain Fructooligosaccharides) while Enfamil Neuropro has three prebiotics (2′-FL HMO – Galactooligosaccharides – Polydextrose). Moreover, Similac Advance doesn’t use palm oil among fat sources. Also, Similac Pro Advance has a whey-to-casein ratio of 48:52 whereas the Neuropro formula has a ratio of 60:40.

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott
Prebiotics will promote the growth of beneficial bacteria (probiotics), and a well-fed probiotic will help with digestive health.

Extra Features:
Enfamil Neuropro has introduced the MFGM components whey protein concentrate, this MFGM (milk fat globule membrane) has a lot of benefits, it protects against some infectious diseases and some cognitive benefits (brain development).
Whereas Similac Pro Advance added the OptiGRO feature which is a blend of DHA, Lutein, and Vitamin E. This blend helps promote eye health and brain development, and to support the development of cells.
Nutrients, Vitamins, and Minerals Comparison :

Sizes, Prices, and Rating Comparison :
In terms of price, Similac Advance is cheaper than Neuropro and has multiple sizes and RTF form, but the latter formula shows better results as mom’s reviews shows

Where to Buy?
Enfamil Neuropro Infant | Similac Advance |
---|---|
Buy 20.7 oz HERE | Buy 12.4 oz HERE |
Buy 28.3 oz HERE | – |
Buy 31.4 oz HERE | Buy 30.8 oz HERE |
– | Buy 40 oz HERE |
Buy Ready to use Here | Buy Ready-to-feed |
Final Thoughts:
Among all these formulas, the best alternative for Enfamil Neuropro Infant in the Similac brand is Similac Advance, Similac pro Advance, and the 360 Total Care formulas because they are all standard milk-based formulas for babies with no health issues and they have the same protein, carbohydrate, and fat sources. In terms of price, Similac Advance and Pro Advance are way cheaper than the 360 Total Care formula. However, this last is the closest one to breastmilk.
The other formulas will be a good substitute for Enfamil Neuropro if your baby has lactose sensitivity problems or negative reactions to standard milk-based formulas.