Similac Advance Vs Enfamil Neuropro: What’s The Difference?

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As parents embark on the exciting journey of nurturing their newborns, one of the most critical decisions they face is choosing the right infant formula. Similac Advance and Enfamil NeuroPro are two leading brands in the infant formula market, trusted by countless parents worldwide.

In this article, we will delve into a comprehensive comparison of Similac Advance and Enfamil NeuroPro, shedding light on the key aspects that matter most to parents: user reviews, ingredients, nutrients, and price.

What’s The Difference Between Similac Advance and Enfamil Neuropro?

Enfamil Neuropro and Similac Advance are standard milk-based formulas designed for babies 0-12 months with no sensitivity or allergy, but they differ in their approach:

Enfamil NeuroPro is a non-GMO formula featuring MFGM for brain development, HuMO 6 for immune health, and three prebiotics to support digestion whereas Similac Advance contains OptiGRO for brain and eye development, one prebiotic, and is palm oil-free but not labeled as GMO-free.

Parent’s Reviews Comparison:

When it comes to the experiences of parents using Similac Advance and Enfamil NeuroPro, it’s clear that both formulas have garnered a mix of positive and negative reviews. These reviews can be valuable insights for parents trying to make an informed decision about their baby’s nutrition:

Similac Advance:

Positive Reviews:

On the positive side, many parents find Similac Advance easy to mix and prepare. The convenience of preparation is often a crucial factor for busy parents. Additionally, the absence of digestive issues is a significant advantage, as a formula that is gentle on a baby’s stomach is highly desirable.

The reports of good taste are reassuring, indicating that babies are accepting and enjoying this formula. Furthermore, Similac Advance often receives praise for being a more budget-friendly option, providing cost savings. The larger can size is also appreciated as it reduces the frequency of having to repurchase.

Negative Reviews:

On the downside, some parents have reported sensitivity issues with Similac Advance. It’s worth noting that infant formula can affect each baby differently, and these sensitivities may be unique to certain individuals.

Enfamil NeuroPro:

Positive Reviews:

Enfamil NeuroPro, on the other hand, also has its share of positive and negative feedback. The taste is often well-received, as parents report that their babies seem to enjoy it. The formula’s ease of preparation is another positive aspect, providing convenience for parents.

The fact that it’s easy to digest is highly valued, as this can help reduce discomfort in babies. Some parents find it to be a good value for the price, acknowledging the cost may be higher but justifiable given the formula’s benefits.

Negative Reviews:

However, the cost of Enfamil NeuroPro is a common concern for some parents, who perceive it as expensive. Transition issues have also been reported, meaning that switching to this formula can sometimes pose challenges. Additionally, a few parents mention an unpleasant odor associated with the formula, which can be a drawback for those who are sensitive to smells.

Related: Similac 360 Total Care Vs Enfamil Neuropro

Ingredients Comparison:

Age Range:

Both Enfamil NeuroPro and Similac Advance are suitable for infants aged 0-12 months.

Protein Source:

Both Enfamil NeuroPro and Similac Advance use nonfat milk as their primary protein source. This choice mirrors breast milk’s composition, which is ideal for infants. Additionally, both formulas include whey protein concentrate, which is easy to digest and provides essential amino acids necessary for infant growth and development.

Whey to Casein Ratio:

Enfamil NeuroPro maintains a whey-to-casein ratio of 65% to 35%. This ratio is closer to that of breast milk, making it easier for some infants to digest and absorb.

Similac Advance has a slightly different ratio of 48% whey to 52% casein. While it’s not an exact match to breast milk, it may be suitable for some infants.

Carbohydrate Source:

Both formulas contain 100% lactose as the carbohydrate source, mirroring the natural sugar found in breast milk. Lactose is well-tolerated and provides essential energy for growing infants.

Fat Source:

Enfamil NeuroPro’s fat blend includes palm oil, high oleic sunflower oil, soy oil, and coconut oil. This diverse blend aims to provide a balanced source of fat, along with essential fatty acids like DHA and ARA for brain and eye development.

Similac Advance is palm oil-free and its fat blend comprises high oleic safflower oil, soy oil, and coconut oil, along with DHA and ARA, aiming to provide essential fats for infant development.

Extra Features:

Enfamil NeuroPro includes MFGM (Milk Fat Globule Membrane) in its ingredients. MFGM is associated with brain development, and its presence in this formula is meant to provide added support in this crucial area.

Additionally, Enfamil NeuroPro features HuMO6, an immune blend that consists of 2′-FL HMO (Human Milk Oligosaccharide), Polydextrose, Galactooligosaccharides, Vitamin C & E, and Selenium. This blend focuses on supporting the immune system and overall well-being.

Similac Advance promotes OptiGro, a blend of essential ingredients (DHA, Lutein, and Vitamin E) designed to support brain and eye development, as well as overall growth.

Related: Enfamil Neuropro Vs. Neuropro Care


Enfamil NeuroPro contains 2′-FL HMO, Polydextrose, and Galactooligosaccharides, which are prebiotic components that can promote healthy digestion and strengthen the immune system.

Similac Advance includes short-chain Fructooligosaccharides (FOS) as its prebiotic source. FOS is known for its positive effects on the gut microbiome, aiding in digestion.


Enfamil NeuroPro is GMO-free, providing assurance to parents who have concerns about genetically modified ingredients in their baby’s formula.

Similac Advance, while not labeled as GMO-free, adheres to strict quality and safety standards.

Source of ARA and DHA:

Both formulas utilize Mortierella alpina oil as the source of ARA and Schizochytrium sp. oil as the source of DHA. These essential fatty acids are critical for brain and eye development.

Generic Brands:

Both Enfamil NeuroPro and Similac Advance have generic counterparts available, which offer a more budget-friendly option for parents looking to save on infant formula costs. Read Best 9 Generic Similac Advance and Best 9 Generic Brands of Enfamil NeuroPro.

Nutrients Comparison:


When it comes to macronutrients, these two formulas exhibit distinct profiles. Enfamil NeuroPro has a relatively higher protein and carbohydrate content, making it a choice that might provide more energy and support for an active infant.

On the other hand, Similac Advance features a greater fat content, which can be valuable for infants who require extra fat for their development.


The vitamin content between Enfamil NeuroPro and Similac Advance varies subtly. Enfamil NeuroPro is notably enriched with higher levels of Vitamin C, D, E, K, B12, Pantothenic acid, and Folic acid. These vitamins play critical roles in immune support, bone health, skin health, and overall growth.

Conversely, Similac Advance contains comparatively more Vitamin B1, B2, Niacin, and Biotin, focusing on metabolic processes and energy production.

Choline and Inositol:

Both formulas provide 24 mg of Choline and 24 mg of Inositol per 100 calories. These compounds play essential roles in infant development, particularly in brain and neural development.

Related: Enfamil Neuropro Vs Similac Pro Advance


In terms of minerals, Enfamil NeuroPro is fortified with higher levels of Phosphorus, Magnesium, Zinc, Manganese, Selenium, Sodium, and Potassium. These minerals are essential for bone health, muscle function, and overall cellular processes. In contrast, Similac Advance provides more Copper and Chloride, supporting various physiological functions in the body.

Price Comparison:

When choosing between Enfamil Neuropro and Similac Advance, considering the size, price, and user ratings is essential. Here’s a closer look at the details:

12.4 oz
17.94 $
1.45 /oz

20.7 oz
34.87 $
1.69 /oz
Buy 20.7 oz
28.3 oz
46.87 $
1.66 /oz
Buy 28.3 oz
31.4 oz
51.00 $
1.62 /oz
Buy 31.4 oz
30.8 oz
32.54 $
1.06 /oz

40 oz
99.5 ¢/oz

32 fl oz
11.82 $
36.9 ¢/fl oz
Buy 32 fl oz
32 Fl Oz
24.4 ¢/fl oz

4.8 of 5.0
10740 reviews
4.7 of 5.0
2290 reviews

Enfamil Neuropro:

  • Enfamil Neuropro is available in various sizes, offering options to suit different needs. For instance, the 20.7 oz container is priced at $34.87, which calculates to $1.69 per ounce. The 28.3 oz container is slightly larger and is priced at $46.87, costing $1.66 per ounce. Moreover, the 31.4 oz container is available for $51.00, at a rate of $1.62 per ounce.
  • If you prefer ready-to-feed formula, the 32 fl oz option is priced at $11.82, equivalent to 36.9 cents per fluid ounce. This formula has received a remarkable user rating of 4.8 out of 5.0 based on 10,740 reviews.

Similac Advance:

  • Similac Advance also offers various sizes to accommodate different preferences. The 12.4 oz container is available for $17.94, which comes to $1.45 per ounce. The 30.8 oz container is priced at $32.54, at a rate of $1.06 per ounce, making it a cost-effective choice for those seeking a larger container. If you opt for an even bigger size, the 40 oz container is available for $39.78, translating to $0.99 per ounce, making it one of the more budget-friendly options.
  • For those who prefer ready-to-feed formula, the 32 fl oz option is priced at $7.82, equivalent to 24.4 cents per fluid ounce. Similac Advance has a strong user rating of 4.7 out of 5.0 based on 2,290 reviews.


  • Both Enfamil Neuropro and Similac Advance are available in a convenient ready-to-feed format, catering to the needs of busy parents.

In summary, Enfamil Neuropro tends to be expensive. However, it has garnered higher user ratings, indicating a high level of user satisfaction. Similac Advance, on the other hand, provides more budget-friendly options, particularly in larger container sizes, making it a cost-effective choice.

Can You Mix Enfamil Neuropro and Similac Advance?

Mixing Enfamil Neuropro and Similac Advance is generally safe since both formulas are of the same type and share similar main ingredients, they have nonfat milk and whey protein concentrate as a protein source and lactose as a carbohydrate source.

How to Switch Between Enfamil Neuropro and Similac Advance?

Here’s a step-by-step guide on how to make the switch:

  1. Choose the New Formula: Determine which formula you want to switch to, either from Enfamil Neuropro to Similac Advance or vice versa.
  2. Gradual Transition: Start by mixing the current formula with the new one in varying ratios. Begin with a small proportion of the new formula and gradually increase it over several days or even a week.
    • Day 1-2: Mix 25% of the new formula with 75% of the current formula.
    • Day 3-4: Increase the new formula to 50%, mixed with 50% of the old formula.
    • Day 5-6: Use a 75% new formula to 25% old formula ratio.
    • Day 7 and beyond: Transition to 100% of the new formula.
  3. Observe Your Baby: Pay close attention to your baby’s response during the transition. Look for any signs of discomfort, digestive issues, or allergies. If you notice any adverse reactions, consult your healthcare provider for further guidance.
  4. Ensure Consistency: Once your baby has fully transitioned to the new formula, it’s important to stick with it to maintain consistent nutrition.
  5. Hydration: Keep your baby well-hydrated during the transition. If you notice changes in feeding patterns, consult your healthcare provider.
  6. Preparation: Follow the mixing and preparation instructions provided on the formula containers to ensure the correct concentration and temperature.

The Best One?

Choosing the “best” formula between Similac Advance and Enfamil Neuropro is a matter of assessing your priorities and your baby’s individual needs. Let’s delve deeper into the advantages of each formula:

Similac Advance:

  • Palm Oil-Free: Similac Advance stands out for being palm oil-free, a characteristic that can be crucial for parents who prefer formulas without palm oil due to concerns about its potential effects on nutrient absorption.
  • Cost-Effective: This formula offers cost-effective options, making it a practical choice for families who are mindful of their budget while ensuring their baby’s nutritional needs are met.
  • OptiGRO: Similac Advance incorporates the OptiGRO feature, which includes a blend of essential ingredients for the baby’s growth and development. This could be seen as an extra nutritional advantage.

Enfamil Neuropro:

  • Non-GMO: Enfamil Neuropro is non-GMO, which is a key selling point for parents who prioritize avoiding genetically modified ingredients in their baby’s diet.
  • Three Prebiotics: The inclusion of three prebiotics in this formula promotes digestive health, potentially reducing the likelihood of digestive issues in infants.
  • MFGM: Enfamil Neuropro contains MFGM, an ingredient beneficial for brain development. It supports cognitive function and brain growth, making it an attractive choice for parents who prioritize this aspect of infant nutrition.
  • HuMO6: The addition of HuMO6, a blend for immune health, can be highly valuable in bolstering your baby’s immune system, especially in the early stages of life.

The “best” choice between Similac Advance and Enfamil Neuropro depends on what aspects of infant nutrition are most important to you. If you emphasize non-GMO ingredients, enhanced brain development, a robust immune system, and optimal digestive health, then Enfamil Neuropro may be the preferable option. However, if you’re looking for a more budget-friendly formula, free from palm oil, and with additional nutritional value, Similac Advance is a strong candidate.


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