Similac Pro Advance Vs All Enfamil Formulas: Full Comparison

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Similac Pro Advance is a regular milk-based formula designed for babies who haven’t milk protein or lactose sensitivity. It’s made from nonfat milk, whey protein concentrate, and 100% lactose. Furthermore, it has an extra feature called OptiGro which is a blend of DHA, lutein, and vitamin E for eye, brain, and cell development.

Moreover, most babies like the taste of Similac Pro Advance, but it may cause gas for some.

In this article, we will see a full comparison between Similac Pro Advance and all Enfamil formulas. Stay with me!

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Similac Pro Advance vs Enfamil Infant:

Similac Pro Advance vs Enfamil Infant

Similac Pro Advance and Enfamil Infant are standard milk-based formulas designed for babies with no sensitivity issues made from nonfat milk, whey protein concentrate, and 100% lactose. The difference between them is that Enfamil Infant contains palm oil and has a whey to casein ratio of 60:40 whereas Pro Advance has 48:52. Furthermore, Similac has introduced the OptiGro feature in the Pro Advance formula which is a blend of DHA, lutein, and vitamin E for eye, brain, and cell development, and it has the new HMO prebiotic (2′-FL HMO) to help promote the gut health.

In terms of nutrients and price, Enfamil Infant is enriched more than Pro Advance with vitamins and minerals and has a cheaper ready-to-feed form.

I did a full comparison between Enfamil Neuropro and Pro Advance if you want to check!

Moms Reviews:

Similac Pro AdvanceEnfamil Infant
Positive
Reviews
Good taste
Available in RTF
Good taste
Easy to mix
Easy to digest
Available in RTF
Negative
Reviews
May cause gashas palm oil

Can you switch between Similac Pro Advance and Enfamil Infant?

Yes, you can switch between Similac Pro Advance and Enfamil Infant interchangeably because they are regular milk-based formulas and have the same protein, carbohydrate, and fat sources. The absence of some ingredients (palm oil) or prebiotics doesn’t impact your baby’s health. The most important thing to consider is protein and carbohydrate sources.

This table shows a full comparison between Similac Pro Advance and Enfamil Infant. For a better view please rotate your phone.

Similac Pro AdvanceEnfamil Infant
Protein sourceNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio48:5260:40
Carbohydrate source 100% Lactose100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGro
Prebiotics2′-FL HMO
Short-chain Fructooligosaccharides
– Galactooligosaccharides
– Polydextrose
Generic Brands9 Generic brands9 Generic brands
Protein (g)2.07 /100 Cal2 /100 Cal
Fat (g)5.6 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.7 /100 Cal11.3 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal6 /100 Cal
Calcium (mg)78 /100 Cal78 /100 Cal
Phosphorus (mg)42 /100 Cal43 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)24 /100 Cal27 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium Sp. oilCrypthecodinium cohnii oil
Size and Price30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
12.5 oz
17.26 $
1.38 /oz

21.1 oz
25.27 $
1.20 /oz

29.4 oz
35.83 $
1.22 /oz

32 fl oz
8.98$
28.1 ¢/fl oz
Rating4.5 of 5.0
665 reviews
4.8 of 5.0
3133 reviews
Ready-to-feedYesYes
Where to Buy?Buy 30.8 oz HERE

Buy Ready-to-feed
Buy 12.5 oz HERE

Buy 21.1 oz HERE

Buy 29.4 oz HERE

Buy Ready-to-use
Overall Note7.5/107.5/10
Similac Pro Advance vs Enfamil Infant

Similac Pro Advance vs Enfamil Enspire:

Similac Pro Advance vs Enfamil Enspire

Similac Pro Advance and Enfamil Enspire are both regular milk-based formulas made from nonfat milk, whey protein concentrate, and 100% lactose. However, they differ in fat sources, Enfamil Enspire has palm oil, also, it’s enriched with vitamins and minerals more than Pro Advance whereas the latter is palm oil-free and has the new 2′-FL HMO prebiotic.

In terms of extra features, Enfamil Enspire has introduced Omega 3 DHA, MFGM (milk fat globule membrane) extracted from whey protein concentrate and protects against some infectious diseases and some cognitive benefits (brain development).

Also, Lactoferrin which is a protein source that protects against viruses and infections and helps regulate iron absorption by the body. In contrast, Pro Advance has the OptiGro feature which is a blend of DHA, lutein, and vitamin E for eye, brain, and cell development

Moreover, Enfamil Enspire is more expensive than Pro Advance and hasn’t an RTF form.

Also read: 14 Easy Ways To Save Money On Baby Formula

Moms Reviews:

Similac Pro AdvanceEnfamil Enspire
Positive
Reviews
Good taste
Available in RTF
Cheaper
Good taste
Easy to mix
Easy to digest
Negative
Reviews
May cause gasDoesn’t have a small size
Doesn’t have RTF
Overpriced

Can you switch between Similac Pro Advance and Enfamil Enspire?

Yes, your baby can take Similac Pro Advance and Enfamil Enspire interchangeably in case you didn’t find your primary formula because they are of the same type (regular milk-based formulas) and have the same protein, carbohydrate, and fat sources. The absence of some ingredients (palm oil), prebiotics, or extra features doesn’t impact your baby’s health. The most important thing to consider is protein and carbohydrate sources.

This table shows a full comparison between Similac Pro Advance and Enfamil Enspire. For a better view please rotate your phone.

Similac Pro AdvanceEnfamil Enspire
Protein sourceNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio48:5260:40
Carbohydrate source 100% Lactose100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOmega 3 DHA
Lactoferrin
MFGM
Prebiotics2′-FL HMO
Short-chain Fructooligosaccharides
– Galactooligosaccharides
– Polydextrose
Generic Brands9 Generic brands9 Generic brands
Protein (g)2.07 /100 Cal2.1 /100 Cal
Fat (g)5.6 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.7 /100 Cal11.3 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal78 /100 Cal
Phosphorus (mg)42 /100 Cal43 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)24 /100 Cal27 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium Sp. oilCrypthecodinium cohnii oil
Size and Price30.8 oz
37.48 $
1.22 /oz


32-fl oz
10.42$
32.6 ¢/fl oz
20.5 oz
39.98 $
1.95 /oz

30 oz
56.97 $
1.90 /oz
Rating4.5 of 5.0
665 reviews
4.8 of 5.0
1693 reviews
Ready-to-feedYesNo
Where to Buy?
Buy 30.8 oz HERE

Buy Ready-to-feed
Buy 20.5 oz HERE

Buy 30 oz HERE
Overall Note7.5/107/10
Similac Pro Advance vs Enfamil Enspire

Similac Pro Advance vs Enfamil Neuropro Sensitive:

Similac Pro Advance vs Enfamil Neuropro Sensitive:

There is a big difference between Similac Pro Advance and Enfamil Neuropro Sensitive because the latter is a lactose-reduced formula made from milk protein isolate, whey protein concentrate, and only 1% lactose designed for babies who have lactose sensitivity whereas Similac Pro Advance is a regular milk-based formula for babies with no health issues.

Moms Reviews:

Similac Pro AdvanceEnfamil Neuropro Sensitive
Positive
Reviews
Good taste
Available in RTF
Cheaper
– Good for babies with
lactose sensitivity
– Good for reflux
– Good for gas
– Good taste
Negative
Reviews
May cause gasDoesn’t have a big size
Doesn’t have RTF
Expensive
Hard to find

Can you switch between Similac Pro Advance and Enfamil Neuropro Sensitive?

In case your baby has bad reactions to regular formulas (Pro Advance, Enfamil Infant, Enspire..) due to lactose sensitivity, then you can switch to Enfamil Neuropro Sensitive because it’s lactose-reduced. However, doing the opposite is not recommended unless your baby was recovered from lactose sensitivity.

This table shows a full comparison between Similac Pro Advance and Enfamil Neuropro Sensitive. For a better view please rotate your phone.

Similac Pro AdvanceEnfamil Neuropro Sensitive
Protein sourceNonfat Milk
Whey Protein Concentrate
70%  Milk Protein Isolate
30% whey protein-lipid concentrate
Whey to Casein Ratio48:5260:40
Carbohydrate source 100% Lactose– 1% Lactose
– 99% Corn Syrup
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroMFGM
Prebiotics2′-FL HMO
Short-chain Fructooligosaccharides
2′-FL HMO
Generic Brands9 Generic brands7 Generic brands
Protein (g)2.07 /100 Cal2.2 /100 Cal
Fat (g)5.6 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.7 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal88 /100 Cal
Phosphorus (mg)42 /100 Cal59 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)24 /100 Cal33 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium Sp. oilSchizochytrium sp. oil
Size and Price30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
19.5 oz
33.77 $
1.73 /oz
Rating4.5 of 5.0
665 reviews
4.8 of 5.0
621 reviews
Ready-to-feedYesNo
Where to Buy?Buy 30.8 oz HERE

Buy Ready-to-feed
Buy 19.5 oz HERE
Overall Note8/107.5/10
Similac Pro Advance vs Enfamil Neuropro Sensitive

Similac Pro Advance vs Enfamil Neuropro Gentlease:

Similac Pro Advance vs Enfamil Neuropro Gentlease:

There is a big difference between Similac Pro Advance and Enfamil Neuropro Gentlease because the latter is a partially hydrolyzed and lactose-reduced formula by 80% designed for babies who have sensitivity to the intact cow’s milk protein and lactose. In contrast, Similac Pro Advance is a regular milk-based formula for babies with no health issues.

Image source: Nestle Health Science

Moms Reviews:

Similac Pro AdvanceEnfamil Neuropro Gentlease
Positive
Reviews
Good taste
Available in RTF
Powder is cheaper
– Good for fussiness
– Good for gas
– Good for reflux
– RTF is cheaper
Negative
Reviews
May cause gasTaste not so pleasant
doesn’t mix well

Can you switch between Similac Pro Advance and Enfamil Neuropro Gentlease?

In case your baby has negative reactions to standard milk-based formulas due to intact cow’s milk protein or lactose, then you can switch to Enfamil Neuropro Gentlease because it has a gentle protein for your baby’s tummy. However, doing the opposite is not recommended unless your baby was recovered from his sensitivity.

This table shows a full comparison between Similac Pro Advance and Enfamil Neuropro Gentlease. For a better view please rotate your phone.

Similac Pro AdvanceEnfamil Neuropro Gentlease
Protein sourceNonfat Milk
Whey Protein Concentrate
Partially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Whey to Casein Ratio48:5260:40
Carbohydrate source 100% Lactose80 % Corn syrup solids
20 % Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroMFGM
Prebiotics2′-FL HMO
Short-chain Fructooligosaccharides
2′-FL HMO
Generic Brands9 Generic brands6 Generic brands
Protein (g)2.07 /100 Cal2.3 /100 Cal
Fat (g)5.6 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.7 /100 Cal10.8 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal70 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal82 /100 Cal
Phosphorus (mg)42 /100 Cal46 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)24 /100 Cal40 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium Sp. oilSchizochytrium sp. oil
Size and Price30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
19.5 oz
27.98 $
1.44/oz

27.4 oz
38.36 $
1.40 /oz

35.2 oz
47.46 $
1.35 /oz

32 Fl Oz
9.64$
30.1 ¢/fl oz
Rating4.5 of 5.0
665 reviews
4.6 of 5
3370 reviews
Ready-to-feedYesYes
Where to Buy?
Buy 30.8 oz HERE

Buy Ready-to-feed
Buy 19.5 oz HERE

Buy 27.4 oz HERE

Buy 35.2 oz HERE

Buy Ready-to-use
Overall Note7.5/108/10
Similac Pro Advance vs Enfamil Neuropro Gentlease

Similac Pro Advance vs Enfamil Reguline:

Similac Pro Advance vs Enfamil Reguline:

The difference between Similac Pro Advance and Enfamil Reguline is that the latter is a partially hydrolyzed and lactose-reduced formula by 50% designed for babies who have sensitivity to the intact cow’s milk protein and lactose while Similac Pro Advance is a regular milk-based formula for babies with no health issues. Moreover, Enfamil Reguline has a low iron level than Pro Advance.

Similac Pro AdvanceEnfamil Reguline
Positive
Reviews
Good taste
Available in RTF
Cheaper
– Great for constipation
– Soft stools
– Good taste
– Easy to mix
Negative
Reviews
May cause gasExpensive
Not Available in big sizes

Can you switch between Similac Pro Advance and Enfamil Reguline?

In case your baby has negative reactions to standard milk-based formulas due to intact cow’s milk protein or lactose, then you can switch to Enfamil Reguline because it has a gentle protein for your baby’s tummy.

However, if your baby is still sensitive to the intact cow’s milk, it’s not recommended to switch from Reguline to Pro Advance.

This table shows a full comparison between Similac Pro Advance and Enfamil Reguline. For a better view please rotate your phone.

Similac Pro AdvanceEnfamil Reguline
Protein sourceNonfat Milk
Whey Protein Concentrate
Partially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Whey to Casein Ratio48:5260:40
Carbohydrate source 100% Lactose50 % Corn syrup solids
50 % Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGro
Prebiotics2′-FL HMO
Short-chain Fructooligosaccharides
Galactooligosaccharides
polydextrose
Generic Brands9 Generic brands6 Generic brands
Protein (g)2.07 /100 Cal2.3 /100 Cal
Fat (g)5.6 /100 Cal5.3 /100 Cal
Carbohydrate (g)10.7 /100 Cal11.1 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal2 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal12 /100 Cal
Inositol (mg)24 /100 Cal6 /100 Cal
Calcium (mg)78 /100 Cal82 /100 Cal
Phosphorus (mg)42 /100 Cal46 /100 Cal
Iron (mg)1.8 /100 Cal1.5 /100 Cal
Zinc (mg)0.75 /100 Cal1 /100 Cal
Manganese (mcg)5 /100 Cal15 /100 Cal
Sodium (mg)24 /100 Cal36 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium Sp. oilCrypthecodinium cohnii oil
Size and Price30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
12.4 oz
18.72 $
1.51 /oz

19.5 oz
29.98 $
1.54/oz
Rating4.5 of 5.0
665 reviews
4.8 of 5.0
1020 reviews
Ready-to-feedYesNo
Where to Buy?
Buy 30.8 oz HERE

Buy Ready-to-feed
Buy 12.4 oz HERE

Buy 19.5 oz HERE
Overall Note7.5/108/10
Similac Pro Advance vs Enfamil Reguline

Final Thoughts:

Of all these formulas, the best alternative to Pro Advance in the Enfamil brand is Enfamil Infant, Enfamil Enspire, and Enfamil Neuropro because they are regular milk-based formulas made for babies with no health issues. In terms of price, Similac Pro Advance and Enfamil Infant are the cheapest in powder form whereas Enfamil Infant is the cheapest one in the ready-to-use form.

The other Enfamil formulas could be alternatives to Pro Advance in case your baby has an allergy to lactose or the intact cow’s milk protein.

Credit:

Versus Vectors by Vecteezy

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