Key Differences:

Similac Advance and 360 Total Care are both standard milk-based formulas designed for babies with no health issues. The difference between them is that Similac Advance is cheap and includes OptiGRO for brain and eye development, while Similac 360 Total Care is NON-GMO and has 5 HMO prebiotics to help digestive health, closely resembling breast milk.

The Best One?

Determining the “best” formula between Similac Advance and Similac 360 Total Care depends on various factors, including your baby’s individual needs and your specific preferences. Here are some considerations to help you make an informed decision:

1. Baby’s Nutritional Requirements: Both formulas meet the basic nutritional needs of infants.
2. Gut Health: For a happy tummy, Similac 360 Total Care is the best choice because it offers a more extensive array of prebiotics for digestive health.
3. Price: Similac Advance generally offers a more cost-effective option, especially in larger sizes, which may be a significant factor for some parents.
4. Customer Reviews: Both formulas have received positive reviews, with slight variations in customer ratings but Similac 360 Total Care is the most loved one.

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Mom’s Reviews Comparison:

Similac 360 Total Care:

Positive Reviews:

Good Taste: Many moms appreciate that Similac 360 Total Care is well-received by their babies, indicating a positive taste.

Easy to Travel With: The formula’s convenience for travel is a plus for parents on the go.

Easy to Use: Users find Similac 360 Total Care easy to prepare, making feeding a smooth process.

Good for Gas: Some parents report that this formula helps reduce gas and discomfort in their babies.

Gentle on Baby’s Stomach: The formula is praised for being gentle on the stomach, potentially reducing instances of colic or fussiness.

Negative Reviews:

High Price: Some parents express concern about the cost of Similac 360 Total Care, which can be a drawback for budget-conscious families.

May Cause Spit-Up: A few users mention that their babies experienced spit-up or regurgitation with this formula.

Dark or Unusual Stool Colors: Unusual stool colors can be concerning for parents and have been reported.

Hard to Find in Stores: Availability issues in physical stores may pose challenges for some parents.

Similac Advance:

Positive Reviews:

Easy to Mix: Users find Similac Advance easy to prepare, with minimal clumping or mixing issues.

No Digestive Issues: Some parents report that their babies experience no digestive discomfort or issues with this formula.

Good Taste: The positive taste of this formula is a common remark, indicating that babies generally enjoy it.

Cheap: Price affordability is a pro, especially for those looking for a budget-friendly option.

Large Can Size: The availability of larger can sizes may be convenient for parents who want to buy in bulk.

Negative Reviews:

Sensitivity Issues: Some moms indicate that their babies experienced sensitivity issues with Similac Advance.

Related: Similac 360 Total Care Vs Similac Total Comfort

Ingredients Comparison:

Protein Source and Whey to Casein Ratio:

Both Similac Advance and Similac 360 Total Care derive their primary protein from nonfat milk and whey protein concentrate. This choice reflects the aim to provide a protein source that closely resembles breast milk. Furthermore, both formulas maintain the same whey-to-casein ratio of 48:52, a ratio that is consistent with the natural composition of breast milk and is generally well-tolerated by most infants.

Carbohydrate Source:

In terms of carbohydrates, both formulas exclusively use 100% lactose. Lactose is the primary carbohydrate naturally found in breast milk and plays a vital role in providing energy to growing infants.

Fat Source:

The fat sources in both Similac Advance and Similac 360 Total Care are comprised of High Oleic Safflower Oil, Soy Oil, and Coconut Oil. These fats provide essential fatty acids necessary for brain development and overall growth.

Extra Features:

Similac Advance includes an additional feature known as OptiGro. This proprietary blend consists of DHA (Docosahexaenoic Acid), lutein, and vitamin E. DHA is crucial for brain development, while lutein and vitamin E contribute to healthy eye development.

Similac 360 Total Care, on the other hand, does not incorporate the OptiGro feature. Instead, it focuses on other components, as discussed below.

Prebiotics:

A notable difference between the two formulas is their prebiotic content. Similac Advance contains Short-chain Fructooligosaccharides (FOS), which can support the growth of beneficial gut bacteria.

In contrast, Similac 360 Total Care includes an extensive array of prebiotics, such as 2′-FL HMO (Human Milk Oligosaccharide), Lacto-N-Tetraose, 3-Fucosyllactose, 6′-Sialyllactose, and 3′-Sialyllactose. These specific prebiotics aim to more closely mimic the composition of breast milk. They support the development of a baby’s immune system and digestive health, fostering a balance of beneficial gut bacteria.

Generic Brands:

Both Similac Advance and Similac 360 Total Care have generic counterparts available in the market, providing parents with more affordable alternatives while maintaining the core nutritional components.

I have made a full article about the best 9 generic brands of Similac Advance if you want to check!!

In conclusion, while Similac Advance and Similac 360 Total Care share fundamental ingredients such as their protein and carbohydrate sources, they differ significantly in their prebiotic content and the presence of additional features like OptiGro. Similac 360 Total Care distinguishes itself by offering a more comprehensive blend of prebiotics, closely mimicking the composition of breast milk to support immune and digestive health.

Nutrients Comparison:

When comparing Similac Advance and Similac 360 Total Care in terms of their micronutrients and vitamins per 100 calories, we find that both formulas provide very similar levels of these essential nutrients:

Macronutrients:

Both formulas offer the same amounts of protein (2.07 grams) and fat (5.6 grams), but different levels of carbohydrates (10.7 grams for Similac Advance and 10.5 grams for Similac 360 Total Care). This balance of macronutrients is designed to support the growth and development of infants.

Vitamins:

• Both formulas provide identical amounts of several essential vitamins, including Vitamin A (300 IU), Vitamin D (60 IU), Vitamin E (1.5 IU), Vitamin K (8 mcg), Thiamin (Vitamin B1, 100 mcg), Riboflavin (Vitamin B2, 150 mcg), Vitamin B6 (60 mcg), Vitamin B12 (0.25 mcg), Niacin (1050 mcg), Folic Acid (15 mcg), Pantothenic Acid (450 mcg), and Biotin (4.4 mcg).
• Vitamin C (Ascorbic acid) content is also consistent between the two formulas, with both providing 9 mg per 100 calories.
• Choline and Inositol, which are important for brain development, are present in equal amounts in both Similac Advance and Similac 360 Total Care, at 24 mg each per 100 calories.

Overall, when it comes to micronutrients and vitamins, Similac Advance and Similac 360 Total Care offer nearly identical levels per 100 calories, ensuring that infants receive the essential nutrients required for their healthy growth and development. Parents can confidently choose between these formulas, knowing that their baby will receive consistent and adequate nutrition in this regard.

Minerals:

Both Similac Advance and Similac 360 Total Care provide similar mineral profiles, ensuring that infants receive essential minerals necessary for their growth, development, and overall well-being including:

Calcium: Essential for the development of strong bones and teeth, as well as for muscle function and blood clotting.

Phosphorus: Works in conjunction with calcium to support bone health, and it plays a key role in energy metabolism and cellular function.

Iron: Critical for the formation of red blood cells, carrying oxygen throughout the body, and supporting cognitive development.

Copper: Important for the formation of red blood cells and maintaining healthy bones and nerves.

Related: Similac Advance Vs Similac Total Comfort: Full Comparison

Price Comparison:

When comparing the prices of Similac Advance and Similac 360 Total Care, along with their respective sizes and ratings, here’s a brief overview:

Similac Advance:

• Available in 12.4 oz size at $17.46, which translates to approximately $1.41 per ounce.
• Also available in larger sizes: 30.8 oz at $32.54 ($1.06 per ounce) and 40 oz at $39.78 ($0.99 per ounce).
• Smaller 32 Fl Oz option at $7.82, equivalent to 24.4 cents per fluid ounce.
• Holds a rating of 4.7 out of 5.0 based on 1472 reviews.

Similac 360 Total Care:

• Offered in a 20.6 oz size at $35.99, which comes to approximately $1.75 per ounce.
• Also available in a 30.8 oz size at $44.88, priced at around $1.46 per ounce.
• Additionally, a 32-fl-oz size is available at $9.82, equivalent to 30.7 cents per fluid ounce.
• Holds a slightly higher rating of 4.8 out of 5.0 based on 197 reviews.

In terms of price, Similac Advance generally offers a more cost-effective option, especially in larger quantities, with prices as low as $0.99 per ounce for the 40 oz size. Similac 360 Total Care, while slightly more expensive per ounce, may be preferred by some parents for its unique features and slightly higher customer rating.

Where to Buy?

Similac Advance	Similac 360 Total Care
Buy 12.4 oz HERE Buy 30.8 oz HERE Buy 40 oz HERE Buy Ready-to-feed	Buy 20.6 oz HERE Buy 30.8 oz HERE Buy Ready-to-use

Switching From Similac 360 Total Care to Similac Advance:

It is safe to switch between Similac 360 Total Care and Similac Advance interchangeably because they are the same; regular milk-based formulas for babies with no health issues, but the switching is better to be done gradually to help your baby adjust. Here’s a general guideline:

1. Transition Gradually: Start by mixing your baby’s current formula (Similac 360 Total Care) with Similac Advance in the following way:
   • Day 1-2: 75% Similac 360 Total Care, 25% Similac Advance
   • Day 3-4: 50% Similac 360 Total Care, 50% Similac Advance
   • Day 5-6: 25% Similac 360 Total Care, 75% Similac Advance
   • Day 7 onward: Switch entirely to Similac Advance
2. Observe Your Baby: During the transition, closely monitor your baby for any signs of discomfort, digestive issues, or allergies. If you notice any concerns, consult with your pediatrician for guidance.
3. Maintain Consistency: Stick to the new formula once the transition is complete to allow your baby’s system to adjust fully.

Remember that every baby is unique, and their response to a formula switch may vary. Always follow your pediatrician’s recommendations for the best results.

The Best Alternative to Similac 360 Total Care:

When considering alternatives to Similac 360 Total Care, it’s essential to select a milk-based formula, NON-GMO and has prebiotics. Here are some notable alternatives to Similac 360 Total Care:

1. Similac Pro-Advance:
   • Key Features: Similac Pro-Advance is an advanced formula that contains two prebiotics (2′-FL HMO and fructooligosaccharides) to support a baby’s immune system and digestive health. It is also non-GMO, palm oil free, and includes the OptiGRO feature which makes it the best alternative to 360 Total Care. Read Similac Pro Advance vs 360 Total Care
2. Similac Advance:
   • Key Features: Similac Advance is a trusted and widely used infant formula that closely resembles breast milk. It contains a combination of nonfat milk and whey protein concentrate, 100% lactose as the carbohydrate source, and essential nutrients like DHA, lutein, and vitamin E for brain and eye development.
3. Enfamil NeuroPro:
   • Key Features: Enfamil NeuroPro is formulated with a blend of nonfat milk and whey protein concentrate. It contains MFGM (Milk Fat Globule Membrane) and triple prebiotics (GOS, 2′-FL HMO, and polydextrose) to support brain development and digestive health. It is also non-GMO and offers DHA for cognitive development. Read Enfamil Neuropro vs 360 Total Care.
4. Enfamil Enspire:
   • Key Features: Enfamil Enspire combines GOS, 2′-FL HMO, and polydextrose prebiotics for digestive health. It also includes MFGM and DHA for brain development.

The Best Alternative to Similac Advance:

1. Similac Pro-Advance:
   • Key Features: Similac Pro-Advance contains the 2′-FL HMO prebiotic for immune support, along with essential nutrients like DHA, lutein, and vitamin E for brain and eye development. Read Similac Advance and Pro Advance.
2. Similac 360 Total Care:
   • Key Features: Similac 360 Total Care is formulated with multiple prebiotics for digestive health. It’s designed to closely mimic the composition of breast milk and offers essential nutrients. Read Similac Advance Vs 360 Total Care.
3. Enfamil Infant:
   • Key Features: Enfamil Infant is designed to provide complete nutrition with a balanced blend of proteins, carbohydrates, and fats. It’s suitable for most babies and supports overall growth.
4. Enfamil NeuroPro:
   • Key Features: Enfamil NeuroPro includes MFGM and the 2′-FL HMO prebiotic, promoting brain development and digestive health. It also provides DHA for cognitive development. Read Enfamil Neuropro vs Similac Advance.
5. Enfamil Enspire:
   • Key Features: Enfamil Enspire combines GOS, 2′-FL HMO, and polydextrose prebiotics for digestive health. It also includes MFGM and DHA for brain development. Read Enfamil Enspire Optimum Vs Similac 360 Total Care.
6. Gerber Good Start Gentle:
   • Key Features: Gerber Good Start Gentle is designed for easy digestion and includes prebiotics similar to those found in breast milk. It’s a suitable option for babies with sensitive tummies.