Enfamil Gentlease Vs All Similac Formulas: The Ultimate Comparison

You are currently viewing Enfamil Gentlease Vs All Similac Formulas: The Ultimate Comparison

Enfamil Gentlease is a partially hydrolyzed and lactose-reduced milk-based formula by 80% to help reduce gas, fussiness, and crying because the Gentlease formula breakdown the nonfat milk protein a little bit in size to be closer to the protein found in breast milk so that to ease digestion.

In this article, we will see a complete comparison between Enfamil Gentlease and all Similac formulas to help you choose the right one for your LO.

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Similac Total Comfort vs Enfamil Gentlease vs Similac Pro Total Comfort

Similac Total Comfort vs Enfamil Gentlease vs Similac Pro Total Comfort

Similac Total Comfort, Enfamil Gentlease, and Similac Pro Total Comfort are partially hydrolyzed and lactose-reduced formulas, except that Gentlease hydrolyzes the nonfat milk which contains 60% whey and 40% casein and has 20% lactose plus 80% of corn syrup as carbohydrate sources. In contrast, Similac Total Comfort and Pro Total Comfort are chopped a little bit in size 100% whey protein and have only 1% lactose plus corn maltodextrin and sugar as carb sources, making them a good choice for babies with lactose sensitivity.

Furthermore, Similac Pro Total Comfort and Total Comfort don’t use palm oil among fat sources and have the OptiGro which is a blend of DHA, lutein, and vitamin E for eye, brain, and cells development. Also, the Total Comfort formula has the FOS prebiotics to help boost digestive health whereas the Pro Total Comfort has two prebiotics (FOS and 2′-FL HMO) and both formulas are enriched with minerals more than the Gentlease formula.

On the other hand, Enfamil Gentlease is sugar-free and available in three sizes and it is enriched with vitamins more than the Total Comfort Formula.

Similac Pro Total Comfort is the only one available in a ready-to-feed version.

Palm oil may cause malabsorption of fat and calcium which can lead to constipation. However, it’s not always the case, most babies are drinking formula with palm oil and have no health issues.

Whey protein is easily digested by the body while the casein becomes curds in the stomach and takes time to be digested.

Image source: Nestle Health Science

Moms Reviews:

Enfamil GentleaseSimilac Total ComfortSimilac Pro Total Comfort
Positive
Reviews
Great for gas
Great for soft stomachs
Less colic
Less spit up
Great value for the money
Good for gas
Good taste
Less Expensive
Good taste
Easy to digest
Negative
Reviews
Bad Taste
Missing lid
No ready-to-use version
Hard to mixHard to mix
Spit up
Bad gas pain

About the missing lids of the Gentlease formula, I don’t know if the reason is the company or Amazon. it’s better to buy it from a local store.

Can You Switch Between Enfamil Gentlease, Similac Total Comfort, and Similac Pro Total Comfort?

You can switch from Enfamil Gentlease to Similac Total Comfort and Pro Total Comfort since they are partially hydrolyzed formula, also the two latter formulas are lactose-reduced more than Enfamil Gentlease which make them a good substitute in case your baby shows bad reactions to the Gentlease formula.

However, doing the opposite may cause some negative reactions especially if your LO is diagnosed as sensitive to lactose because the latter amount he eats on Gentlease will increase.

This table shows a complete comparison between Enfamil Gentlease, Similac Total Comfort, and Pro Total Comfort:

Enfamil GentleaseSimilac Total ComfortSimilac Pro Total Comfort
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Partially hydrolyzed whey
protein
Partially hydrolyzed whey
protein
Whey to Casein Ratio60:40100% whey100% whey
Carbohydrate source80 % Corn syrup solids
20 % Lactose
1% Lactose
Corn Maltodextrin
Sugar
1% Lactose
Corn Maltodextrin
Sugar
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
Extra FeaturesOptiGroOptiGro
PrebioticsShort-chain Fructooligosaccharides2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands6 Generic brands6 Generic brands6 Generic brands
Protein (g)2.3 /100 Cal2.32 /100 Cal2.32 /100 Cal
Fat (g)5.3 /100 Cal5.4 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.8 /100 Cal10.7 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal 9 /100 Cal9 /100 Cal
Inositol (mg)6 /100 Cal24 /100 Cal24 /100 Cal
Calcium (mg)82 /100 Cal105 /100 Cal105 /100 Cal
Phosphorus (mg)46 /100 Cal75 /100 Cal75 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)15 /100 Cal5 /100 Cal5 /100 Cal
Sodium (mg)40 /100 Cal44 /100 Cal44 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz

27.7 oz
35.83 $
1.29 /oz
12.6 oz
17.99 $
1.43/oz
22.5 oz
28.98 $
1.29 /oz

29.8 oz
36.96 $
1.24 /oz
Whose Cheaper?cheapercheaper
Rating4.8 of 5.0
3589 reviews
4.5 of 5.0
311 reviews
4.1 of 5.0
950 reviews
Ready-to-feedNoNoYes
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 12.6 oz HERE
Buy 22.5 oz HERE

Buy 29.8 oz HERE

Buy Ready-to-feed
Overall Note6/108/108/10
Similac Total Comfort vs Enfamil Gentlease vs Similac Pro Total Comfort

Enfamil Gentlease vs Similac 360 Total Care Sensitive

Enfamil Gentlease vs Similac 360 Total Care Sensitive

Enfamil Gentlease and Similac 360 Total Care Sensitive are designed for babies with gas and fussiness as a consequence of lactose sensitivity by reducing lactose percentage, but they differ in the percentage of the latter, the Gentlease formula reduces it by 80% whereas the other reduces it by 98%. Also, they differ in the protein source, Similac 360 Total Care Sensitive has the milk protein isolate which is extracted from skim milk powder, it has been filtered to remove all or most of the minerals and the lactose in it. In contrast, Enfamil Gentlease contains partially hydrolyzed nonfat milk plus whey protein concentrate to become closer to breast milk to ease digestion.

Furthermore, Similac 360 Total Care Sensitive is palm oil-free and has 5 HMO prebiotics to help promote digestive health, also it’s available in a ready-to-feed version.

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

Moms Reviews:

Enfamil GentleaseSimilac 360 Total Care Sensitive
Positive
Reviews
Great for gas
Great for soft stomachs
Less colic
Less spit up
Great value for the money
Not part of the recall
Good for constipation
Good for spit up
Mixed well
Negative
Reviews
Bad Taste
Missing lid
No ready-to-use version
Expensive

Related: The Best Formula For Babies With Colic in 2022!

Can You Switch Between Enfamil Gentlease and Similac 360 Total Care Sensitive?

In case your baby shows bad reactions to Enfamil Gentlease, the 360 Total Care Sensitive formula will be a good substitute because it’s lactose-reduced more than Gentlease plus the 5 HMO prebiotics and the non-existence of palm oil.

This table shows a complete comparison between Enfamil Gentlease and Similac 360 Total Care Sensitive:

Enfamil GentleaseSimilac 360 Total Care Sensitive
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Milk Protein Isolate
Whey to Casein Ratio60:40Info Not Found
Carbohydrate source80 % Corn syrup solids
20 % Lactose
2% Lactose
Corn Syrup
Sugar
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
Extra Features
Prebiotics2′-FL HMO
Lacto-N-Tetraose
3-Fucosyllactose
6′-Sialyllactose
3′-Sialyllactose
Generic Brands6 Generic brands7 Generic brands
Protein (g)2.3 /100 Cal2.1 /100 Cal
Fat (g)5.3 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.8 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal 9 /100 Cal
Inositol (mg)6 /100 Cal24 /100 Cal
Calcium (mg)82 /100 Cal84 /100 Cal
Phosphorus (mg)46 /100 Cal56 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal0.75 /100 Cal
Manganese (mcg)15 /100 Cal5 /100 Cal
Sodium (mg)40 /100 Cal30 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz

27.7 oz
35.83 $
1.29 /oz
20.1 oz
– $
– /oz

30.2 oz
44.88 $
1.49 /oz
Rating4.8 of 5.0
3589 reviews
4.8 of 5.0
604 reviews
Ready-to-feedNoYes
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 20.1 oz HERE

Buy 30.2 oz HERE

Buy Ready-to-feed
Overall Note6/106/10
Similac 360 Total Care Sensitive vs Enfamil Gentlease

Similac Sensitive vs Enfamil Gentlease vs Similac Pro Sensitive

Similac Sensitive vs Enfamil Gentlease vs Similac Pro Sensitive

Enfamil Gentlease, Similac Sensitive, and Pro Sensitive are designed for babies with gas and fussiness due to lactose sensitivity by reducing lactose percentage, but each brand reduced it by a different percentage, in the Similac Sensitive and Pro Sensitive the lactose is reduced by 99% whereas in the Gentlease formula it’s reduced by 80%.

Among the differences, we find that Similac Sensitive & Pro Sensitive have the milk protein isolate as a protein source with whey to casein ratio of 18:82 while Enfamil Gentlease contains partially hydrolyzed nonfat milk plus whey protein concentrate to ease digestion. The ratio of whey to casein in this formula is 60:40.

The ratio of whey to casein in breastmilk is 70% to 30% and 80% to 20% in early lactation and decreases to 50% to 50% in late lactation because the whey protein is easily digested by the body while the casein becomes curds in the stomach and take time to be digested. Thus, Enfamil Gentlease has the closest ratio to breastmilk.

Furthermore, Similac Sensitive & Pro Sensitive have the OptiGro feature which is a blend of DHA, lutein, and vitamin E for eye, brain, and cells development, also they have prebiotics to help promote digestive health, and they are available in a ready-to-feed version.

Enfamil GentleaseSimilac SensitiveSimilac Pro Sensitive
Positive
Reviews
Great for gas
Great for soft stomachs
Less colic
Less spit up
Great value for the money
Good for fussiness
Good taste
Good for reflux
Less Expensive
Good for fussiness
Less Expensive
Easy to digest
Good taste
Negative
Reviews
Bad Taste
Missing lid
No ready-to-use version
Too much foam
May cause gas
Doesn’t mix well
Available in one size
May cause constipation
May cause gas
Too foamy

According to moms reviews, Similac Sensitive and Pro Sensitive are too foamy and sometimes it’s hard to mix them. The solution to this problem is to use Dr. Brown bottles because it mixes well and the bubbles are no longer found especially if you swirl the bottle.

Related: Top Best Automatic And Manual Formula Dispensers in 2022

Can You Switch Between Enfamil Gentlease, Similac Sensitive, and Similac Pro Sensitive?

In case your baby shows bad reactions to Enfamil Gentlease, the Similac Sensitive & Pro Sensitive formula will be a good substitute because they are lactose-reduced more than Gentlease and have no palm oil to ensure the absorption of fat and calcium.

This table shows a complete comparison between Enfamil Gentlease, Similac Sensitive, and Pro Sensitive:

Enfamil GentleaseSimilac SensitiveSimilac Pro Sensitive
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Milk Protein IsolateMilk Protein Isolate
Whey to Casein Ratio60:4018:8218:82
Carbohydrate source80 % Corn syrup solids
20 % Lactose
 1% Lactose
Corn Syrup
Sugar
 1% Lactose
Corn Syrup
Sugar
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOptiGro
PrebioticsShort-chain Fructooligosaccharides– 2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands6 Generic brands7 Generic brands7 Generic brands
Protein (g)2.3 /100 Cal2.1 /100 Cal2.1 /100 Cal
Fat (g)5.3 /100 Cal5.4 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.8 /100 Cal10.9 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal 9 /100 Cal9 /100 Cal
Inositol (mg)6 /100 Cal24 /100 Cal24 /100 Cal
Calcium (mg)82 /100 Cal84 /100 Cal84 /100 Cal
Phosphorus (mg)46 /100 Cal56 /100 Cal56 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)15 /100 Cal5 /100 Cal5 /100 Cal
Sodium (mg)40 /100 Cal30 /100 Cal30 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz

27.7 oz
35.83 $
1.29 /oz
12.5 oz
17.46 $
1.40/oz


34.9 oz
37.92 $
1.09 /oz
29.8 oz
36.96 $
1.24 /oz
Rating4.8 of 5.0
3589 reviews
4.5 of 5.0
1482 reviews
4.3 of 5.0
895 reviews
Ready-to-feedNoYesYes
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 12.5 oz HERE

Buy 34.9 oz HERE

Buy Ready-to-feed
Buy 29.8 oz HERE

Buy Ready-to-feed
Overall Note6/107/107.5/10
Similac Pro Sensitive vs Enfamil Gentlease vs Similac Sensitive

Similac Pro Advance vs Enfamil Gentlease vs Similac Advance

Similac Pro Advance vs Enfamil Gentlease vs Similac Advance

The difference between Enfamil Gentlease and Similac Advance & Pro Advance is that these late are standard milk-based formulas designed for babies with no allergic reactions that’s why they use a nonfat milk protein as a protein source and 100% lactose as a carbs source whereas Enfamil Gentlease is a partially hydrolyzed and lactose-reduced formula that is enriched with nutrient, vitamins, and minerals more than Similac Advance & Pro Advance.

Also read: Similac Pro Advance Vs All Enfamil Formulas: Full Comparison

Enfamil GentleaseSimilac AdvanceSimilac Pro Advance
Positive
Reviews
Great for gas
Great for soft stomachs
Less colic
Less spit up
Great value for the money
Easy to mix
Great taste
Available in a ready-to-use
Cheaper

Good taste
Available in a ready-to-use
Cheaper
Negative
Reviews
Bad Taste
Missing lid
No ready-to-use version
It may cause spit up
it may cause gas
May cause gas

Can You Switch Between Enfamil Gentlease, Similac Advance, and Similac Pro Advance?

The safe switch is between formulas of the same type or from standard milk-based formula to the partially hydrolyzed to the extensively hydrolyzed to the amino acid formula in case of sensitivity problems. Thus you can switch from Similac Advance & Pro Advance to Enfamil Gentlease and not the opposite.

This table shows a complete comparison between Enfamil Gentlease, Similac Advance, and Pro Advance:

Enfamil GentleaseSimilac AdvanceSimilac Pro Advance
Protein sourcePartially hydrolyzed nonfat milk
Whey protein concentrate solids (soy)
Nonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio60:4048:5248:52
Carbohydrate source80 % Corn syrup solids
20 % Lactose
 100% Lactose100% Lactose
Fat source– Palm Oil
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOptiGro
PrebioticsShort-chain Fructooligosaccharides– 2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands6 Generic brands9 Generic brands9 Generic brands
Protein (g)2.3 /100 Cal2.07 /100 Cal2.07 /100 Cal
Fat (g)5.3 /100 Cal5.6 /100 Cal5.6 /100 Cal
Carbohydrate (g)10.8 /100 Cal10.7 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal60 /100 Cal
Vitamin E (IU)2 /100 Cal1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
12 /100 Cal 9 /100 Cal9 /100 Cal
Inositol (mg)6 /100 Cal24 /100 Cal24 /100 Cal
Calcium (mg)82 /100 Cal78 /100 Cal78 /100 Cal
Phosphorus (mg)46 /100 Cal42 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal1.8 /100 Cal
Zinc (mg)1 /100 Cal0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)15 /100 Cal5 /100 Cal5 /100 Cal
Sodium (mg)40 /100 Cal24 /100 Cal24 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilSchizochytrium Sp. oilSchizochytrium Sp. oil
Size and Price12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz

27.7 oz
35.83 $
1.29 /oz
12.4 oz
17.46 $
1.41/oz

30.8 oz
32.54 $
1.06 /oz

40 oz
39.78$
0.99 /oz
30.8 oz
36.96 $
1.20 /oz
Rating4.8 of 5.0
3589 reviews
4.7 of 5.0
1472 reviews
4.5 of 5.0
780 reviews
Ready-to-feedNoYesYes
Where to Buy?Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 12.4 oz HERE

Buy 30.8 oz HERE

Buy 40 oz HERE

Buy Ready-to-feed
Buy 30.8 oz HERE

Buy Ready-to-feed
Overall Note6/107.5/107.5/10
Similac Pro Advance and Advance vs Enfamil Gentlease

Final Thoughts:

Among all these formulas, the best alternative for Enfamil Gentlease in the Similac brand is the Total Comfort and Pro Total Comfort formulas because they are of the same type (partially hydrolyzed formulas) and are lactose-reduced more than the Gentlease formula. In terms of price, Similac Total Comfort & Pro Total Comfort is cheaper than Enfamil Gentlease.

Similac 360 Care Sensitive, Similac Sensitive, and Similac Pro Sensitive could be also an alternative to Enfamil Gentlease although they haven’t chopped the protein in the size. You can’t know until your baby try it because every baby is different.

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