Enfamil Gentlease Vs All Similac Formulas: The Ultimate Comparison

You are currently viewing Enfamil Gentlease Vs All Similac Formulas: The Ultimate Comparison

Enfamil Gentlease is a partially hydrolyzed and lactose-reduced milk-based formula by 80% to help reduce gas, fussiness, and crying because the Gentlease formula breakdown the nonfat milk protein a little bit in size to be closer to the protein found in breast milk so that to ease digestion.

In this article, we will see a complete comparison between Enfamil Gentlease and all Similac formulas to help you choose the right one for your LO.

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Similac Total Comfort vs Enfamil Gentlease vs Similac Pro Total Comfort

Similac Total Comfort vs Enfamil Gentlease vs Similac Pro Total Comfort

Similac Total Comfort, Enfamil Gentlease, and Similac Pro Total Comfort are partially hydrolyzed and lactose-reduced formulas, except that Gentlease hydrolyzes the nonfat milk which contains 60% whey and 40% casein and has 20% lactose plus 80% of corn syrup as carbohydrate sources.

In contrast, Similac Total Comfort and Pro Total Comfort are chopped a little bit in size 100% whey protein, and have only 1% lactose plus corn maltodextrin and sugar as carb sources, making them a good choice for babies with lactose sensitivity.

Furthermore, Similac Pro Total Comfort and Total Comfort don’t use palm oil among fat sources and have the OptiGro which is a blend of DHA, lutein, and vitamin E for eye, brain, and cells development.

Also, the Total Comfort formula has the FOS prebiotics to help boost digestive health whereas the Pro Total Comfort has two prebiotics (FOS and 2′-FL HMO) and both formulas are enriched with minerals more than the Gentlease formula.

On the other hand, Enfamil Gentlease is sugar-free and available in three sizes and it is enriched with vitamins more than the Total Comfort Formula.

Similac Pro Total Comfort is the only one available in a ready-to-feed version.

Palm oil may cause malabsorption of fat and calcium which can lead to constipation. However, it’s not always the case, most babies are drinking formula with palm oil and have no health issues.

Whey protein is easily digested by the body while casein becomes curds in the stomach and takes time to be digested.

Image source: Nestle Health Science

Moms Reviews:

About the missing lids of the Gentlease formula, I don’t know if the reason is the company or Amazon. it’s better to buy it from a local store.

Can You Switch Between Enfamil Gentlease, Similac Total Comfort, and Similac Pro Total Comfort?

You can switch from Enfamil Gentlease to Similac Total Comfort and Pro Total Comfort since they are partially hydrolyzed formula, also the two latter formulas are lactose-reduced more than Enfamil Gentlease which make them a good substitute in case your baby shows bad reactions to the Gentlease formula.

However, doing the opposite may cause some negative reactions especially if your LO is diagnosed as sensitive to lactose because the latter amount he eats on Gentlease will increase.

Price Comparison:

FormulaSize and Price
Enfamil Gentlease12.4 oz
18.26 $
1.47/oz
Buy 12.4 oz HERE

19.9 oz
28.30 $
1.42 /oz
Buy 19.9 oz HERE

27.7 oz
35.83 $
1.29 /oz
Buy 27.7 oz HERE
Similac Total
Comfort
12.6 oz
17.99 $
1.43/oz
Buy 12.6 oz HERE
Similac Pro
Total Comfort
22.5 oz
28.98 $
1.29 /oz
Buy 22.5 oz HERE

29.8 oz
36.96 $
1.24 /oz
Buy 29.8 oz HERE

32 fl oz
11.30 $
35.3 ¢/fl oz
Buy Ready-to-feed

Enfamil Gentlease vs Similac 360 Total Care Sensitive

Enfamil Gentlease vs Similac 360 Total Care Sensitive

Enfamil Gentlease and Similac 360 Total Care Sensitive are designed for babies with gas and fussiness as a consequence of lactose sensitivity by reducing lactose percentage, but they differ in the percentage of the latter, the Gentlease formula reduces it by 80% whereas the other reduces it by 98%.

Also, they differ in the protein source, Similac 360 Total Care Sensitive has the milk protein isolate which is extracted from skim milk powder, it has been filtered to remove all or most of the minerals and the lactose in it.

In contrast, Enfamil Gentlease contains partially hydrolyzed nonfat milk plus whey protein concentrate to become closer to breast milk to ease digestion.

Furthermore, Similac 360 Total Care Sensitive is palm oil-free and has 5 HMO prebiotics to help promote digestive health, also it’s available in a ready-to-feed version.

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

Moms Reviews:

Related: The Best Formula For Babies With Colic in 2022!

Can You Switch Between Enfamil Gentlease and Similac 360 Total Care Sensitive?

In case your baby shows bad reactions to Enfamil Gentlease, the 360 Total Care Sensitive formula will be a good substitute because it’s lactose-reduced more than Gentlease plus the 5 HMO prebiotics and the non-existence of palm oil.

Price and Rating:

Enfamil GentleaseSimilac 360 Total
Care Sensitive
12.4 oz
18.26 $
1.47/oz

19.9 oz
28.30 $
1.42 /oz

27.7 oz
35.83 $
1.29 /oz
20.1 oz
– $
– /oz

30.2 oz
44.88 $
1.49 /oz

8fl oz
Case of 24
67.56 $
35.2 ¢/fl oz
4.8 of 5.0
3589 reviews
4.8 of 5.0
604 reviews
No RTFHas RTF
Buy 12.4 oz HERE

Buy 19.9 oz HERE

Buy 27.7 oz HERE

Buy 20.1 oz HERE

Buy 30.2 oz HERE

Buy Ready-to-feed

Nutrition Comparison:

Similac Sensitive vs Enfamil Gentlease vs Similac Pro Sensitive

Similac Sensitive vs Enfamil Gentlease vs Similac Pro Sensitive

Enfamil Gentlease, Similac Sensitive, and Pro Sensitive are designed for babies with gas and fussiness due to lactose sensitivity by reducing lactose percentage, but each brand reduced it by a different percentage, in the Similac Sensitive and Pro Sensitive the lactose is reduced by 99% whereas in the Gentlease formula it’s reduced by 80%.

Among the differences, we find that Similac Sensitive & Pro Sensitive have the milk protein isolate as a protein source with whey to casein ratio of 18:82 while Enfamil Gentlease contains partially hydrolyzed nonfat milk plus whey protein concentrate to ease digestion. The ratio of whey to casein in this formula is 60:40.

The ratio of whey to casein in breastmilk is 70% to 30% and 80% to 20% in early lactation and decreases to 50% to 50% in late lactation because the whey protein is easily digested by the body while the casein becomes curds in the stomach and take time to be digested. Thus, Enfamil Gentlease has the closest ratio to breastmilk.

Furthermore, Similac Sensitive & Pro Sensitive have the OptiGro feature which is a blend of DHA, lutein, and vitamin E for eye, brain, and cells development, also they have prebiotics to help promote digestive health, and they are available in a ready-to-feed version.

Mom’s Reviews:

According to moms’ reviews, Similac Sensitive and Pro Sensitive are too foamy and sometimes it’s hard to mix them. The solution to this problem is to use Dr. Brown bottles because it mixes well and the bubbles are no longer found especially if you swirl the bottle.

Related: Top Best Automatic And Manual Formula Dispensers in 2022

Nutrition Comparison:

Can You Switch Between Enfamil Gentlease, Similac Sensitive, and Similac Pro Sensitive?

In case your baby shows bad reactions to Enfamil Gentlease, the Similac Sensitive & Pro Sensitive formula will be a good substitute because they are lactose-reduced more than Gentlease and have no palm oil to ensure the absorption of fat and calcium.

Price Comparison:

FORMULASizes and Prices
Enfamil Gentlease12.4 oz
18.26 $
1.47/oz
Buy 12.4 oz HERE

19.9 oz
28.30 $
1.42 /oz
Buy 19.9 oz HERE

27.7 oz
35.83 $
1.29 /oz
Buy 27.7 oz HERE
Similac Sensitive12.5 oz
17.46 $
1.40/oz

Buy 12.5 oz HERE

34.9 oz
37.92 $
1.09 /oz
Buy 34.9 oz HERE

32 fl oz
7.82 $
24.4 ¢/fl oz
Buy Ready-to-feed
Similac Pro
Sensitive
29.8 oz
36.96 $
1.24 /oz
Buy 29.8 oz HERE

32 fl oz
8.12 $
25.4 ¢/fl oz
Buy Ready-to-feed

Final Thoughts:

Among all these formulas, the best alternative for Enfamil Gentlease in the Similac brand is the Total Comfort and Pro Total Comfort formulas because they are of the same type (partially hydrolyzed formulas) and are lactose-reduced more than the Gentlease formula. In terms of price, Similac Total Comfort & Pro Total Comfort is cheaper than Enfamil Gentlease.

Similac 360 Care Sensitive, Similac Sensitive, and Similac Pro Sensitive could be also an alternative to Enfamil Gentlease although they haven’t chopped the protein in the size. You can’t know until your baby try it because every baby is different.

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