Enfamil Gentlease Vs Enfamil Enspire Optimum: Full Comparison

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Navigating the world of infant formula can be a daunting task for new parents and caregivers. With a multitude of options on the market, choosing the right formula to meet your baby’s unique needs can be overwhelming. Two popular choices that often find themselves in the spotlight are Enfamil Gentlease and Enfamil Enspire Optimum.

As parents, you want the best for your little one, and that includes providing them with the highest quality nutrition and care. To help you make an informed decision, we have undertaken a comprehensive comparison of these two Enfamil formulas, taking into account parent reviews, ingredients, nutrients, and price.

In this article, we’ll delve into the key differences and similarities between Enfamil Gentlease and Enfamil Enspire Optimum, offering insights into which formula might be the right fit for your baby. We’ll examine what parents have to say about their experiences with these products, scrutinize the ingredients to understand their composition and potential benefits, evaluate the nutrient profiles to ensure they meet your baby’s requirements, and finally, consider the price factor, as budget considerations are often a crucial aspect of formula selection.

What’s The Difference Between Enfamil Gentlease and Enspire Optimum?

Enfamil Gentlease is a partially hydrolyzed, lactose-reduced formula, specially designed to ease fussiness, gas, and crying in babies. In contrast, Enfamil Enspire Optimum is a standard milk-based formula suitable for healthy babies without specific health issues. The key difference lies in their formula composition, with Gentlease targeting digestive comfort, while Enspire Optimum serves as a general, high-quality nutrition option.

Parent Reviews Comparison:

enfamil gentlease vs enfamil enspire optimum terms of user reviews

Enfamil Enspire Optimum:

Positive Reviews:

  1. Closest to Breast Milk: Many parents appreciate that Enspire Optimum comes closest to the composition of breast milk. This similarity is often a crucial factor for mothers who are transitioning from breastfeeding to formula feeding. Babies tend to adapt more easily when the formula is comparable to what they’ve been receiving from their mothers.
  2. Smooth Transition from Breastfeeding: Parents often find that their infants transition smoothly from breastfeeding to Enspire Optimum. This transition is crucial for those who need to introduce formula gradually or as a supplement to breastfeeding.
  3. No Digestion Problems: Enspire Optimum receives accolades for causing minimal or no digestive problems in babies. This is particularly reassuring for parents who worry about their baby’s stomach comfort and overall well-being.
  4. Improved Baby Growth and Development: Some parents report noticeable improvements in their baby’s growth and development while using this formula. The rich nutrient profile of Enspire Optimum is designed to support healthy growth, making it a popular choice for parents looking to provide the best nutrition for their little ones.

Negative Reviews:

  1. Overpriced: One common concern among parents is the cost of Enspire Optimum. Some find it relatively more expensive compared to other formula options on the market. This can be a deterrent for budget-conscious families.
  2. Smell/Taste Issues: A few parents have noted that this formula has an unpleasant odor or taste. While it may not impact the baby’s well-being, it can be a drawback for parents who are sensitive to such factors.
  3. Difficulty Dissolving the Formula: Some parents have reported issues with dissolving the formula properly. This can lead to clumps or residue in the bottle, causing inconvenience during feeding.

Related: Enfamil NeuroPro Vs. Enfamil Enspire OPTIMUM: Full Comparison

Enfamil Gentlease:

Positive Reviews:

  1. Good for Gas: Gentlease is highly praised for its effectiveness in reducing gas in infants. Parents often choose this formula to alleviate colic and discomfort caused by excessive gas.
  2. Good for Soft Stomachs: Many parents find that Gentlease is gentle on their baby’s stomach. It is designed to be easy to digest, which can be a relief for parents whose babies have sensitive digestive systems.
  3. Less Colic: The formula is credited with reducing the occurrence of colic, which can be a source of great distress for both babies and their parents. This is a significant benefit that makes Gentlease a popular choice.
  4. Less Spit-Up: Another positive aspect is its ability to minimize spit-up in babies. Parents appreciate that this formula can help reduce the mess and discomfort associated with excessive regurgitation.

Negative Reviews:

  1. Bad Taste: The primary criticism of Gentlease pertains to its taste. Some parents and babies may not find it as palatable as other formulas. This can result in a reluctance to feed and, in some cases, a need for additional flavor masking.

Related: Enfamil Gentlease Vs Enfamil Neuropro Gentlease: What’s The Difference?

Ingredients Comparison:

enfamil enspire optimum vs enfamil gentlease in terms of ingredients

Age Range:

Both Enfamil Gentlease and Enfamil Enspire Optimum cater to the nutritional needs of infants from birth to 12 months, ensuring that they are appropriate for the entirety of the crucial first year of life.

Protein Source:

Enfamil Gentlease derives its protein from partially hydrolyzed nonfat milk whey protein concentrate solids. The partial hydrolyzation process breaks down proteins into smaller, more easily digestible components. This feature can be beneficial for infants who may experience discomfort or colic due to difficulty digesting standard milk-based formulas.

Enfamil Enspire Optimum’s protein blend consists of 55% nonfat milk, 44% whey protein concentrate, and 1% lactoferrin. Lactoferrin is a bioactive protein found in breast milk, known for its potential role in supporting infant immune health. This ingredient is a notable addition for parents seeking to provide their baby with immune-boosting benefits.

Related: Enfamil Gentlease Vs Enfamil Infant: Full Comparison

Whey to Casein Ratio:

Enfamil Gentlease: The whey to casein ratio in this formula is 60:40, which is considered balanced. Whey-dominant formulas are often preferred due to their ease of digestion.

Enfamil Enspire Optimum: This formula has a slightly higher whey-to-casein ratio of 65:35, potentially making it even gentler on an infant’s stomach, as whey proteins tend to be easier to digest.

Carbohydrate Source:

Enfamil Gentlease: It comprises 20% lactose and 80% corn syrup solids. The significant reduction in lactose content (80%) may be beneficial for babies with lactose sensitivity, as it helps prevent digestive discomfort caused by lactose.

Enfamil Enspire Optimum contains 100% lactose as the carbohydrate source. This closely mimics the carbohydrate composition of breast milk, making it suitable for babies who do not have lactose intolerance.

Fat Source:

Both formulas share a similar array of fat sources, including palm oil, high oleic sunflower oil, soy oil, and coconut oil. These fats provide essential fatty acids required for brain and eye development. Additionally, both formulas include DHA and ARA, which are long-chain fatty acids crucial for infant cognitive and visual development.

Extra Features:

Enfamil Gentlease: This formula does not include additional special ingredients beyond the basic nutritional components.

Enfamil Enspire Optimum: In addition to the core nutritional components, Enspire Optimum boasts extra features such as MFGM (Milk Fat Globule Membrane), lactoferrin, and HuMO6 (Premium Immune Blend). MFGM is found in breast milk and may contribute to cognitive development, while lactoferrin and HuMO6 are associated with immune support.

HuMO6 is a proprietary blend found in certain infant formulas, comprising 2′-FL (2′-Fucosyllactose) and LNnT (Lacto-N-neotetraose) Human Milk Oligosaccharides, which are not derived from human milk but mimic the composition of breast milk. This blend also includes essential nutrients such as Vitamin C, Vitamin E, Selenium, and Zinc. Together, these components support immune health, gut health, and overall development in infants, aiming to replicate the benefits of breast milk in formula-fed babies.


Enfamil Gentlease does not contain added prebiotics, which are compounds that support the growth of beneficial gut bacteria.

Enfamil Enspire Optimum is fortified with 2′-FL HMO (Human Milk Oligosaccharide) and Lacto-N-neotetraose, both of which are prebiotic compounds. These prebiotics promote a healthy gut microbiome, potentially enhancing digestion and immune function in infants.


Enfamil Gentlease is not labeled as GMO-free, indicating that it may contain genetically modified ingredients.

Enfamil Enspire Optimum is labeled as GMO-free. For parents who prioritize non-genetically modified ingredients, this can be a significant advantage.

Generic Brands:

Enfamil Gentlease has associated generic brands, providing consumers with multiple options that may be more budget-friendly.

Enspire Optimum is available in association with nine generic brands, offering even more choices for cost-conscious consumers, potentially making it easier to find affordable alternatives.

Source of ARA and DHA:

Both formulas use Mortierella alpina oil as a source of ARA (Arachidonic Acid) and Schizochytrium sp. oil as a source of DHA (Docosahexaenoic Acid). These long-chain fatty acids are vital for infant cognitive and visual development, and their inclusion in both formulas ensures that they meet these essential nutritional needs.

Nutrients Comparison:

enfamil enspire optimum vs enfamil gentlease in terms of macronutrients and vitamins


Enspire Optimum provides 2.1 grams of protein per 100 calories, while Enfamil Gentlease offers slightly more protein at 2.3 grams per 100 calories. This subtle difference in protein content may be advantageous for infants who need additional protein to support their growth and development.


Both formulas contain 5.3 grams of fat per 100 calories. The fat content remains consistent between these formulas, providing essential fatty acids for brain and eye development.


Enfamil Enspire Optimum Contains more carbohydrates, 11.1 grams per 100 calories than Gentlease.


The two formulas are matched in terms of vitamin content including Vitamin A, E, K, C, and B vitamins per 100 calories except for Vitamin D, Enspire Optimum is fortified more with it.

Other Nutrients:

Enfamil Enspire Optimum is enriched more with inositol, 24 mg per 100 calories, which is an important nutrient for brain development.


enfamil enspire optimum vs enfamil gentlease in terms of minerals

In terms of minerals, Enfamil boasts higher levels of calcium, phosphorus, and sodium when compared to Enspire Optimum. This divergence in mineral content is particularly noticeable, signifying that Enfamil provides a more concentrated source of these essential minerals.

The variance in calcium and phosphorus levels is relevant as they play a pivotal role in promoting bone development and growth, while the difference in sodium levels, although not substantial, might be of interest to parents who closely monitor their baby’s sodium intake.

Price Comparison:

When evaluating Enfamil Gentlease and Enfamil Enspire Optimum in terms of price, size, and ratings, several key factors emerge:

12.4 oz
Buy 12.4 oz
20.5 oz
Buy 20.5 oz
19.9 oz
Buy 19.9 oz
27.4 oz
Buy 27.4 oz
27.7 oz
Buy 27.7 oz
30 oz
Buy 30 oz
4.8 of 5.0
2228 reviews
4.8 of 5.0
7096 reviews


Enfamil Gentlease is the more cost-effective option when compared to Enfamil Enspire Optimum. The price per ounce for Gentlease is consistently lower across various sizes. This cost difference may be due to variations in ingredients and additional features found in Enspire Optimum, which contribute to a higher price point.


Both Enfamil Gentlease and Enfamil Enspire Optimum hold the same rating of 4.8 out of 5.0, indicating a high level of customer satisfaction. Enfamil Gentlease has garnered 7,096 reviews, while Enfamil Enspire Optimum has received 2,228 reviews.


Neither Enfamil Gentlease nor Enfamil Enspire Optimum are available as ready-to-feed formulas, so they both require preparation.

How to Switch Between Enfamil Enspire Optimum and Gentlease?

Switching between Enfamil Enspire Optimum and Gentlease can be done gradually or cold turkey, depending on your baby’s tolerance and preferences. Here’s how to do both:

Gradual Switch:

  1. Start by mixing the two formulas, with a higher proportion of the current formula (the one your baby is used to) and a smaller amount of the new formula. For instance, use 75% Enspire Optimum and 25% Gentlease.
  2. Gradually increase the proportion of the new formula while decreasing the old one over several days. For instance, after a few days, switch to a 50-50 mix.
  3. Continue to adjust the ratio until your baby is comfortably consuming the new formula exclusively.

Cold Turkey Switch:

  1. If your baby is known to adapt easily to formula changes, if you prefer a quicker transition, or if you are obliged to switch immediately from one formula to the other.
  2. Ensure you have an adequate supply of the new formula on hand to support the full transition.
  3. Monitor your baby closely for any signs of discomfort or digestive issues during the first few feedings with the new formula.
  4. In case of any adverse reactions or if your baby struggles with the abrupt change, you may need to consider a gradual switch instead.

Whichever method you choose, observe your baby’s reactions, including changes in behavior, stool consistency, and feeding patterns. It’s essential to consult with your pediatrician before making the switch to ensure that the new formula aligns with your baby’s specific needs and any dietary considerations.


In conclusion, the comparison between Enfamil Gentlease and Enfamil Enspire Optimum reveals that both formulas have their own set of strengths and characteristics.

Enfamil Gentlease is designed to ease digestive discomfort (fussiness, gas, and crying), making it a favored choice for infants with sensitive stomachs. On the other hand, Enfamil Enspire Optimum closely mimics the composition of breast milk and offers additional immune-boosting components.

The choice between the two formulas should depend on your baby’s specific needs, your budget, and any particular dietary considerations.

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