Similac Pro Sensitive Vs All Similac Formulas: Full Comparison

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Similac Pro Sensitive is a lactose-reduced formula, made from milk protein isolate and 1% lactose, the other carbohydrate sources are corn syrup and sugar, designed for babies with gas and fussiness due to lactose sensitivity. Moreover, it has an HMO’s prebiotic (2′-FL) to help the immune system and digestive health.

According to moms’ reviews, it shows good results for fussiness and reflux, also it has a good taste. However, it’s too foamy and may cause gas for some babies.

In this article, we will dive into a full comparison between Similac Pro Sensitive and all Similac Formulas to choose the best alternative to this one.

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Similac Sensitive vs Similac Pro Sensitive:

Similac Sensitive vs Similac Pro Sensitive

Similac Sensitive and Pro Sensitive are similar (lactose-reduced formulas), they have the same protein, carbohydrate, and fat source, also the same nutrient value. The only difference between them is in the prebiotics; Similac Pro Sensitive has two prebiotics (2′-FL HMO and FOS) whereas Similac Sensitive has only one prebiotic which is Short-chain Fructooligosaccharides (FOS).

2′-FL (Fucosyl Lactose) is a prebiotic that resembles chemically more than other prebiotics to that found in breast milk (Human Milk Oligosaccharides, or HMO’s).

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

Prebiotics are food for healthy bacteria (probiotics), they help them grow and do their job very well; which is helping the immune system develop properly and easing digestion.

Moms Reviews:

Similac SensitiveSimilac Pro Sensitive
Positive
Reviews
Good for fussiness
Good taste
Good for reflux
Less Expensive
Good for fussiness
Easy to digest
Good taste
Negative
Reviews
Too much foam
May cause gas
Doesn’t mix well
May cause constipation
May cause gas
Too foamy

Can you switch between Similac Sensitive and Pro Sensitive?

Yes, you can feed your baby Similac Sensitive and Pro Sensitive interchangeably because they are of the same type (lactose-reduced formulas) and have the same ingredients and nutrient value. The absence of the 2′-FL HMO prebiotic doesn’t have a negative impact on your baby’s health, babies are doing great!!

The table below will show you a complete comparison between Similac Sensitive and Pro Sensitive, for a better view rotate your phone screen.

Similac SensitiveSimilac Pro Sensitive
Protein sourceMilk Protein IsolateMilk Protein Isolate
Whey to Casein Ratio18:8218:82
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
 1% Lactose
Corn Syrup
Sugar
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOptiGro
PrebioticsShort-chain Fructooligosaccharides– 2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands7 Generic brands7 Generic brands
Protein (g)2.1 /100 Cal2.1 /100 Cal
Fat (g)5.4 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.9 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal84 /100 Cal
Phosphorus (mg)56 /100 Cal56 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal
Sodium (mg)30 /100 Cal30 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price12.5 oz
17.46 $
1.40/oz

34.9 oz
37.92 $
1.09 /oz


32 fl oz
7.82$
24.4 ¢/fl oz
29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
Rating4.5 of 5.0
1482 reviews
4.3 of 5.0
895 reviews
Ready-to-feedYesYes
Where to Buy?
Buy 12.5 oz HERE

Buy 34.9 oz HERE

Buy Ready-to-feed
Buy 29.8 oz HERE

Buy Ready-to-feed
Overall Note7.5/107.5/10
Similac Pro Sensitive vs Similac Sensitive

Similac Pro Sensitive vs Similac Total Comfort vs Similac Pro Total Comfort:

Similac Pro Sensitive vs Similac Total Comfort vs Similac Pro Total Comfort

The difference between Similac Pro Sensitive, Similac Total Comfort, and Pro Total Comfort is that these late have a partially hydrolyzed 100% whey protein and use corn maltodextrin among carbs sources whereas Pro Sensitive has an intact protein (milk protein isolate) with 18% of whey and 82% of casein. In terms of carbohydrate sources, it contains corn syrup instead of corn maltodextrin.

Furthermore, Similac Total Comfort has one prebiotic (FOS) while Pro Sensitive and Pro total Comfort have two prebiotics (2′-FL HMO and FOS) to help good bacteria (probiotics) grow and do their job.

The difference between whey and casein is that the latter takes time to be digested which makes it good at night whereas whey is digested quickly by the body.

Other than that, they are similar; lactose-reduced by 99% and have the same ingredients and nutrient value; they are good alternatives to each other.

A partially hydrolyzed formula is a formula that breakdown the protein a little bit in size to be gentle on babies’ tummies and to not elicit allergic responses by the immune system of babies who have intact cow’s milk protein allergy.

Image source: Nestle Health Science

Moms Reviews:

Similac Pro SensitiveSimilac Total ComfortSimilac Pro Total Comfort
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
Good for gas
Good taste
Good taste
Easy to digest
Available in a ready-to-use
Negative
Reviews
May cause constipation
May cause gas
Too foamy
Hard to mixHard to mix
Spit up
Bad gas pain

Can you switch between Similac Pro Sensitive, Similac Total Comfort, and Pro Total Comfort?

Yes, you can switch between Similac Pro Sensitive, Similac Total Comfort, and Pro Total Comfort as you want in case your baby has a sensitivity to lactose. However, make sure he hasn’t an intact cow’s milk protein allergy, in that case, the only switching you can make is from Pro Sensitive to Similac Total Comfort or Pro Total Comfort because they have a partially hydrolyzed protein.

The table below shows a complete comparison between those formulas in terms of ingredients, features, nutrient value, and price. For a better VIEW rotate your phone screen.

Similac Pro SensitiveSimilac Total ComfortSimilac Pro Total Comfort
Protein sourceMilk Protein IsolatePartially hydrolyzed whey
protein
Partially hydrolyzed whey
protein
Whey to Casein Ratio18:82100% whey100% whey
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
1% Lactose
Corn Maltodextrin
Sugar
1% Lactose
Corn Maltodextrin
Sugar
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOptiGroOptiGro
Prebiotics– 2′-FL HMO
Short-chain Fructooligosaccharides
Short-chain Fructooligosaccharides2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands7 Generic brands6 Generic brands6 Generic brands
Protein (g)2.1 /100 Cal2.32 /100 Cal2.32 /100 Cal
Fat (g)5.4 /100 Cal5.4 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.9 /100 Cal10.7 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal105 /100 Cal105 /100 Cal
Phosphorus (mg)56 /100 Cal75 /100 Cal75 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal5 /100 Cal
Sodium (mg)30 /100 Cal44 /100 Cal44 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilCrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
12.6 oz
17.99 $
1.43/oz
22.5 oz
28.98 $
1.29 /oz

29.8 oz
36.96 $
1.24 /oz

32-fl-oz
11.30$
35.3 ¢/fl oz
Rating4.3 of 5.0
895 reviews
4.5 of 5.0
311 reviews
4.1 of 5.0
950 reviews
Ready-to-feedYesNoYes
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 12.6 oz HEREBuy 22.5 oz HERE

Buy 29.8 oz HERE

Buy Ready-to-feed
Overall Note7.5/108/107.5/10
Similac Pro Sensitive vs Similac Pro Total Comfort vs Similac Total Comfort

Similac Pro Sensitive vs Similac 360 Total Care Sensitive:

Similac Pro Sensitive vs Similac 360 Total Care Sensitive

Similac Pro Sensitive and Similac 360 Total Care Sensitive are similar; they are lactose-reduced formulas and are using the same protein source (milk protein isolate), also they have exactly the same nutrient value. However, they slightly differ in lactose percentage and prebiotics; Similac Pro sensitive has 1% of lactose and 2 prebiotics whereas 360 Total Care Sensitive has 2% of lactose and has 5 HMO’s prebiotics (2′-FL HMO, Lacto-N-Tetraose, 3-Fucosyllactose, 6′-Sialyllactose, 3′-Sialyllactose) which will help the immune system, brain development, and digestive health

In terms of price, Similac Pro Sensitive is way cheaper (1.24$/oz) than 360 Total Care Sensitive (1.49$/oz), but the latter shows better results and isn’t a part of the recall.

Moms Reviews:

Similac Pro SensitiveSimilac 360 Total Care Sensitive
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
Not part of the recall
Good for constipation
Good for spit up
Mixed well
Negative
Reviews
May cause constipation
May cause gas
Too foamy
Expensive

Can you switch between Similac Pro Sensitive and Similac 360 Total Care Sensitive?

Yes, your baby can take Similac Pro Sensitive and Similac 360 Total Care Sensitive interchangeably because they are of the same type (lactose-reduced) and have the same purpose (help reduce fussiness and gas due to lactose sensitivity). Also, they have the same nutrient value.

The lack of some extra features doesn’t have a big impact on your baby’s health.

In the table below you’ll find a full comparison between these two formulas:

Similac Pro SensitiveSimilac 360 Total Care Sensitive
Protein sourceMilk Protein IsolateMilk Protein Isolate
Whey to Casein Ratio18:82Info Not Found
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
2% Lactose
Corn Syrup
Sugar
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGro5 Prebiotics
Prebiotics– 2′-FL HMO
– Short-chain Fructooligosaccharides
2′-FL HMO
Lacto-N-Tetraose
3-Fucosyllactose
6′-Sialyllactose
3′-Sialyllactose
Generic Brands7 Generic brands7 Generic brands
Protein (g)2.1 /100 Cal2.1 /100 Cal
Fat (g)5.4 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.9 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal84 /100 Cal
Phosphorus (mg)56 /100 Cal56 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal
Sodium (mg)30 /100 Cal30 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price29.8 oz
36.96 $
1.24 /oz


32 fl oz
8.12$
25.4 ¢/fl oz
30.2 oz
44.88 $
1.49 /oz
Rating4.3 of 5.0
895 reviews
4.8 of 5.0
604 reviews
Ready-to-feedYesYes
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 20.1 oz HERE

Buy 30.2 oz HERE

Buy Ready-to-feed
Overall Note7.5/107.5/10
Similac Pro Sensitive vs Similac 360 Total Care Sensitive

Similac Advance vs Similac Pro Sensitive vs Similac Pro Advance:

Similac Advance vs Similac Pro Sensitive vs Similac Pro Advance

There is a big difference between Similac Pro Sensitive, Similac Advance, and Pro Advance because these late are standard milk-based formulas designed for babies with no health issues made from nonfat milk plus whey protein concentrate and 100% lactose. In contrast, Similac Pro Sensitive is a lactose-reduced formula by 99% designed for babies with fussiness and gas due to lactose sensitivity.

Moms Reviews:

Similac Pro SensitiveSimilac AdvanceSimilac Pro Advance
Positive
Reviews
Good for fussiness
Easy to digest
Good taste
Easy to mix
Great taste
Available in a ready-to-use
Cheaper
Good taste
Available in a ready-to-use
Negative
Reviews
May cause constipation
May cause gas
Too foamy
It may cause spit up
it may cause gas
May cause gas

Can you switch between Similac Pro Sensitive, Similac Advance, and Pro Advance?

In case your baby drinks Similac Pro Sensitive formula and has already a lactose sensitivity; switching to Similac Advance or Pro Advance is not recommended because they are regular formulas and made from 100% lactose which means the baby will show negative responses. Instead, you can switch to other lactose-reduced formulas like Similac Sensitive, Total Comfort, Pro Total Comfort, 360 Total Care Sensitive…

There are some alternatives to Pro Sensitive in the Enfamil brand that’s why I made a full comparison between Similac Pro Sensitive and all Enfamil formulas if you want to check.

However, switching from Similac Advance or Pro Advance to Pro Sensitive is safe and recommended if your LO shows bad reactions due to lactose sensitivity.

The table below shows a complete comparison between these formulas:

Similac Pro SensitiveSimilac AdvanceSimilac Pro Advance
Protein sourceMilk Protein IsolateNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio18:8248:5248:52
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
 100% Lactose 100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOptiGroOptiGro
Prebiotics– 2′-FL HMO
Short-chain Fructooligosaccharides
Short-chain Fructooligosaccharides2′-FL HMO
– Short-chain Fructooligosaccharides
Generic Brands7 Generic brands9 Generic brands9 Generic brands
Protein (g)2.1 /100 Cal2.07 /100 Cal2.07 /100 Cal
Fat (g)5.4 /100 Cal5.6 /100 Cal5.6 /100 Cal
Carbohydrate (g)10.9 /100 Cal10.7 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal78 /100 Cal78 /100 Cal
Phosphorus (mg)56 /100 Cal42 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal5 /100 Cal
Sodium (mg)30 /100 Cal24 /100 Cal24 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilSchizochytrium sp. oilSchizochytrium sp. oil
Size and Price29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
12.4 oz
17.46 $
1.41/oz

30.8 oz
32.54 $
1.06 /oz


40 oz
39.78$
0.99 /oz

32 Fl Oz
7.82$
24.4 ¢/fl oz
30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
Rating4.3 of 5.0
895 reviews
4.7 of 5.0
1472 reviews
4.5 of 5.0
665 reviews
Ready-to-feedYesYesYes
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 12.4 oz HERE

Buy 30.8 oz HERE

Buy 40 oz HERE

Buy Ready-to-feed
Buy 30.8 oz HERE

Buy Ready-to-feed
Overall Note7.5/108/107.5/10
Similac Pro Sensitive vs Similac Pro Advance vs Similac Advance

Similac Pro Sensitive vs Similac 360 Total Care:

Similac Pro Sensitive vs Similac 360 Total Care

There is a big difference between Similac Pro Sensitive and Similac 360 Total Care because the latter is a regular milk-based formula designed for babies with no health issues made from nonfat milk plus whey protein concentrate and 100% lactose while Pro Sensitive is designed for babies with fussiness and gas due to lactose sensitivity made from milk protein isolate and 1% of lactose.

Can you switch between Similac Pro Sensitive, Similac Advance, and Pro Advance?

In case your baby is on Similac Pro Sensitive formula and has already lactose sensitivity; don’t switch to Similac 360 Total Care because it’s made from 100% lactose that will elicit negative responses. Unless your baby has recovered from this sensitivity then he can take them interchangeably.

However, switching from Similac 360 Total Care to Pro Sensitive is safe and recommended if your LO is lactose intolerant.

The table below shows a complete comparison between Similac Pro Sensitive vs Similac 360 Total Care:

Similac Pro SensitiveSimilac 360 Total Care
Protein sourceMilk Protein IsolateNonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio18:82Not Found
Carbohydrate source 1% Lactose
Corn Syrup
Sugar
 100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGro5 HMO Prebiotics
Prebiotics– 2′-FL HMO
– Short-chain Fructooligosaccharides
2′-FL HMO
Lacto-N-Tetraose
3-Fucosyllactose
6′-Sialyllactose
3′-Sialyllactose
Protein (g)2.1 /100 Cal2.07 /100 Cal
Fat (g)5.4 /100 Cal5.6 /100 Cal
Carbohydrate (g)10.9 /100 Cal10.5 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)84 /100 Cal78 /100 Cal
Phosphorus (mg)56 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal
Sodium (mg)30 /100 Cal24 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHACrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price29.8 oz
36.96 $
1.24 /oz


32 fl oz
8.12$
25.4 ¢/fl oz
20.6 oz
35.99 $
1.75 /oz

30.8 oz
44.88$
1.46 /oz

32-fl-oz
9.82$
30.7 ¢/fl oz
Rating4.3 of 5.0
895 reviews
4.8 of 5.0
197 reviews
Ready-to-feedYesYes
Where to Buy?Buy 29.8 oz HERE

Buy Ready-to-feed
Buy 20.6 oz HERE

Buy 30.8 oz HERE

Buy Ready-to-use
Overall Note7.5/107.5/10
Similac Pro Sensitive vs Similac 360 Total Care

Final Thoughts:

The best alternative to Similac Pro Sensitive in the Similac brand is Similac Sensitive, Similac Total Comfort, Similac Pro Total Comfort, and Similac 360 Total Care Sensitive because they are of the same type (lactose-reduced formulas) and have the same nutrient value.

Image Credit:

Versus Vectors by Vecteezy

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