Similac Total Comfort and Pro Total Comfort are partially hydrolyzed and lactose-reduced formulas designed for babies with gas, fussiness, and crying due to lactose and intact cow’s milk protein sensitivity, they are made from partially hydrolyzed whey protein and 1% of lactose. These two formulas are similar, they have the same protein, carbs, and fat sources. However, they differ in one thing.

In this article, we will dive into a complete comparison between Similac Total Comfort and Pro Total Comfort in terms of mom’s reviews, ingredients, nutrition, and price. Stay with me!!

Mom’s Reviews Comparison:

According to mom’s reviews, Similac Total Comfort has a good taste and shows better results for gas pain. But, it’s hard to mix.

In contrast, Pro Total Comfort is easy to digest and has good taste. However, it’s hard to mix, also, it can cause spit-up and gas pain for some babies.

Not every baby who drinks these formulas will have necessary the same negative responses because every baby is different, you can’t judge until your baby tries.

Ingredients Comparison:

The protein source for these formulas is a partially hydrolyzed whey protein; it’s a whey protein broken a little bit in size to be like that found in breast milk to be gentle on babies’ tummies who have an intact cow’s milk allergy.

Regarding carbohydrate sources, they have corn maltodextrin, sugar, and 1% lactose to not elicit bad responses for the baby in case he has lactose sensitivity.

Furthermore, Similac Total Comfort and Pro Total Comfort have an extra feature called OptiGro which is a blend of DHA, Lutein, and vitamin E to help the brain, cell, and eye development.

The only difference between Similac Total Comfort and Pro Total Comfort is in the prebiotics; the latter formula has the new 2′-FL HMO prebiotic that is naturally found in breast milk whereas Total Comfort doesn’t.

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

The table below shows a complete comparison between these formulas in terms of ingredients:

Both formulas have 6 generic brands to choose from in case you didn’t find them in stores, I wrote an article about the best 6 generic brands of Total Comfort and Pro Total Comfort if you want to check.

Nutrition Comparison:

In terms of Nutrition, Similac Total Comfort and Pro Total Comfort have the same nutrient, vitamin, and mineral values.

Price Comparison:

In terms of price, we can’t judge because they have different sizes, Similac Total Comfort has only one size (12.6 oz) whereas the PRO version has two powder sizes (22.5 oz and 29.8 oz) and a ready-to-feed form. Thus, if you want to save money it’s better to buy big sizes because they are cheap.

Similac Total Comfort	Similac Pro Total Comfort
12.6 oz 17.99 $ 1.43/oz	22.5 oz 28.98 $ 1.29 /oz 29.8 oz 36.96 $ 1.24 /oz 32 Fl Oz 11.30$ 35.3 ¢/fl oz
4.5 of 5.0 335 reviews	4.0 of 5.0 772 reviews
No RTF	Has RTF
Buy 12.6 oz HERE	Buy 22.5 oz HERE Buy 29.8 oz HERE Buy Ready-to-feed

Can You Mix and Switch Between Similac Total Comfort and Pro Total Comfort?

Yes, you can mix and switch between Similac Total Comfort and Pro Total Comfort because they are the same; regular milk-based formulas with the same protein, fat, and carbs sources, designed for babies with gas, fussiness, and crying due to lactose sensitivity or cow’s milk protein allergy. The missing prebiotic in Total Comfort doesn’t make a big difference.

The Best One?

We conclude that the “PRO” word is referring only to the 2′-FL HMO prebiotic, except that both formulas are similar, they have the same protein, carbohydrate, and fat sources, and the same nutrition value your baby needs.

However, according to mom’s reviews, the best one is Similac Total Comfort because it helps with gas contrary to Pro Total comfort which could cause spit-up and gas pain for some babies.