Similac Total Comfort Vs Pro Total Comfort: What’s The Difference?

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What is The Difference Between Them?

Similac Total Comfort and Similac Pro Total Comfort are infant formulas designed for sensitive tummies. Both are composed of 100% partially hydrolyzed whey protein and feature a substantial reduction in lactose content, by nearly 98%, catering to the specific needs of babies with digestive sensitivities. However, they differ in one thing:

The only difference between Similac Total Comfort and Pro Total Comfort is in the prebiotics; Pro Total Comfort has the new 2′-FL HMO prebiotic that is naturally found in breast milk plus Short-chain Fructooligosaccharides whereas Similac Total Comfort has only the Short-chain Fructooligosaccharides prebiotic.

Which One to Choose?

When choosing between the two, there are some differences to consider. Similac Total Comfort has a slightly higher user rating and may be a cost-effective choice for parents who prefer a smaller container. On the other hand, Similac Pro Total Comfort has the 2′-FL HMO prebiotic and offers more size options, including a ready-to-feed version, providing greater convenience and flexibility.

Mom’s Reviews Comparison:

Similac Total Comfort:

Positive Reviews:

  1. Good for Gas: Many moms reported that this formula was effective in reducing gas in their babies. This resulted in less fussiness and discomfort, making both the parents and the infants happier.
  2. Less Colic: Parents who tried Total Comfort found that it helped alleviate colic symptoms in their babies. The formula seemed to bring relief to infants who had been struggling with colic-related issues.
  3. Improved Bowel Movements: Several reviewers mentioned that their babies had better and more regular bowel movements while using this formula. This can be particularly comforting for both the baby and the parents.
  4. Easier Digestion: Moms appreciated that this formula was gentle on their baby’s stomachs. It made the digestion process easier for infants who may have experienced discomfort with other formulas.
  5. Better Sleep: Improved digestion and reduced discomfort seemed to result in better sleep patterns for some babies. This was a welcomed benefit for sleep-deprived parents.

Negative Reviews:

  1. Clumping/Foaming: Some mothers experienced issues with the formula clumping or foaming when preparing it. This could be slightly inconvenient during feeding times.
  2. Gas and Diarrhea: While some moms found it helpful for gas, a few others reported that their babies had gas and diarrhea issues with this formula. It’s essential to recognize that individual responses to formula can vary.
  3. Availability: The availability of Similac Total Comfort may have been an issue for some parents. This could lead to challenges in finding the product in local stores.

Related: Similac Total Comfort Vs. Enfamil Gentlease

Similac Pro Total Comfort:

Positive Reviews:

  1. Easy on Baby’s Tummy: Moms praised Similac Pro Total Comfort for being gentle on their baby’s sensitive stomachs. It was often described as an easy-to-digest formula, providing relief for infants with digestive sensitivities.
  2. Good for Digestive Issues: Reviewers noted that this formula was effective for babies with various digestive issues, such as colic and reflux. It appeared to alleviate discomfort associated with these conditions.
  3. Reduced Gas/Fussiness: Parents observed a decrease in gas and fussiness when their babies were fed this formula. This reduction in discomfort made for a more peaceful and content baby.
  4. Improved Bowel Movements: Similar to Similac Total Comfort, this formula seemed to help with more regular and comfortable bowel movements, which is essential for the well-being of the baby.
  5. Good for Reflux/Colic: Moms found this formula helpful in reducing symptoms of reflux and colic in their infants. It provided relief and comfort to babies who struggled with these conditions.

Negative Reviews:

  1. Constipation: A few parents experienced constipation issues with their babies after using Similac Pro Total Comfort. It’s important to note that individual responses can vary.
  2. Expensive: Some reviewers mentioned that this formula could be relatively expensive, which might be a drawback for cost-conscious parents. It’s essential to weigh the costs against the benefits.
  3. Availability Issues: Similar to Similac Total Comfort, availability problems were noted by some parents, making it harder to find in stores. This might require additional planning when purchasing the formula.
  4. Doesn’t Mix Well: A few moms mentioned difficulties in mixing this formula, which could be inconvenient during feedings. Ensuring that the formula is adequately mixed is essential for the baby’s comfort.

In summary, both Similac Total Comfort and Similac Pro Total Comfort received positive feedback for their abilities to alleviate digestive issues, reduce gas, and improve bowel movements. However, both also faced availability concerns. Similac Total Comfort had mixed reviews regarding gas and clumping issues, while Similac Pro Total Comfort was considered expensive by some parents and had problems with mixing.

Ingredients Comparison:

Age Range:

Both Similac Total Comfort and Similac PRO Total Comfort are formulated for infants within the age range of 0 to 12 months. This means that they can be used from birth throughout the first year of a baby’s life, providing essential nutrition during this critical developmental stage.

Protein Source:

In terms of protein source, both formulas rely on partially hydrolyzed whey protein. Partially hydrolyzed proteins are broken down into smaller, more easily digestible components. This can be beneficial for infants with sensitive tummies as it may reduce the likelihood of protein-related digestive discomfort.

Image source: Nestle Health Science

Whey to Casein Ratio:

Both formulas maintain a 100% whey-based protein source. Whey proteins are known for their high-quality amino acid profile and easy digestibility, making them a good choice for infants.

Carbohydrate Source:

Both formulas predominantly rely on corn maltodextrin and sugar as the primary carbohydrate source and contain a very small percentage of lactose in order to reduce digestive issues like gas, fussiness, or crying due to lactose sensitivity.

Related: Similac Sensitive Vs. Similac Total Comfort

Fats and Oils:

Both formulas incorporate High Oleic Safflower Oil, Soy Oil, and Coconut Oil as sources of essential fatty acids and energy. These fats contribute to the overall nutritional profile.


DHA (docosahexaenoic acid) and ARA (arachidonic acid) are long-chain polyunsaturated fatty acids found in breast milk, and they play a crucial role in infant brain and eye development. Both Similac Total Comfort and Similac PRO Total Comfort include these important components in their formulations, ensuring that infants receive these essential nutrients.

Extra Features:

One notable feature in both formulas is the presence of OptiGro. OptiGro is a blend of DHA, Lutein, and Vitamin E designed to support a baby’s overall growth and development.


Both Similac Total Comfort and Similac PRO Total Comfort incorporate prebiotics in their formulations to support the development of a healthy gut microbiome in infants.

Short-chain Fructooligosaccharides (FOS): These are included in both formulas. FOS are non-digestible carbohydrates that act as food for beneficial gut bacteria. They can help promote the growth of these “friendly” bacteria, contributing to a balanced gut flora and improved digestive health.

2′-FL HMO (2′-Fucosyllactose Human Milk Oligosaccharide): This specific prebiotic is an important component in Similac PRO Total Comfort. 2′-FL HMO is an oligosaccharide naturally found in human breast milk. It’s known for its ability to encourage the growth of beneficial gut bacteria while discouraging the growth of harmful microorganisms. Including 2′-FL HMO in the formula aims to replicate some of the prebiotic benefits of breast milk.


Both Similac Total Comfort and Similac PRO Total Comfort proudly claim to be GMO-Free, meaning that their ingredients do not include genetically modified organisms. This can be an important factor for parents who prefer non-GMO products for their infants.

Generic Brands:

For those who may be looking for more budget-friendly alternatives, both Similac Total Comfort and Similac PRO Total Comfort have equivalent generic brands available in the market. These alternatives aim to provide a similar nutritional profile while potentially reducing costs. Read the best 6 generic brands of Total Comfort and Pro Total Comfort.

Nutrients Comparison:

The macronutrients and vitamin content in both Similac Total Comfort and Similac PRO Total Comfort are very similar, as seen in the provided table.


Protein (g): Both formulas contain 2.32 grams of protein per serving. The protein in these formulas is partially hydrolyzed whey protein, which is easier to digest.

Fat (g): Both formulas provide 5.4 grams of fat per serving. This fat is a crucial source of energy for growing infants.

Carbohydrate (g): Both formulas have 10.7 grams of carbohydrates per serving. These carbohydrates include a combination of 2% lactose and corn maltodextrin, which provide a source of energy for the baby.


In terms of vitamins, both formulas have the same vitamin levels. These vitamins are essential for the healthy growth and development of infants. They play vital roles in various bodily functions, including the development of the immune system, nervous system, and overall well-being.


The mineral content in these formulas is carefully balanced to ensure that infants receive the necessary minerals for their growth and development. The similarity in mineral content between Similac Total Comfort and Similac PRO Total Comfort indicates that both are designed to meet the nutritional needs of infants.

Price Comparison:

In terms of price, Similac Total Comfort is cheaper and has a higher user rating whereas Similac Pro Total Comfort is slightly expensive and has a low user rating indicating the dissatisfaction of parents. But it provides more size options, including a ready-to-feed version.

Similac Total
Similac Pro
Total Comfort
12.6 oz

20.1 oz
29.8 oz
1.38 /oz
32 Fl Oz
35.3 ¢/fl oz

4.5 of 5.0
658 reviews
4.2 of 5.0
1182 reviews

Can You Mix Between Similac Total Comfort and Pro Total Comfort?

Yes, you can mix and switch between Similac Total Comfort and Pro Total Comfort because they are the same; regular milk-based formulas with the same protein, fat, and carbs sources, designed for babies with gas, fussiness, and crying due to lactose sensitivity or cow’s milk protein allergy. The missing prebiotic in Total Comfort doesn’t make a big difference.

How to Switch Between Similac Total Comfort and Pro Total Comfort?

Switching between Similac Total Comfort and Similac PRO Total Comfort infant formulas could be done gradually to minimize digestive upset and help your baby adjust to the new formula or “cold turkey”.

Gradually Switching:

Here’s a step-by-step guide on how to switch gradually between these formulas:

Step 1: Gather Supplies Ensure you have both the Similac Total Comfort and Similac PRO Total Comfort formulas on hand.

Step 2: Gradual Transition To help your baby adapt to the new formula, make the transition gradual. Start by mixing the two formulas together. You can use a formula mixing chart provided by Similac to determine the ratio you should use based on your baby’s current formula consumption.

For example, you can start with a mixture that’s 75% of the old formula and 25% of the new formula for a few days. Gradually increase the proportion of the new formula while decreasing the old formula over about a week. Here’s a sample transition plan:

  • Days 1-2: 75% old formula, 25% new formula.
  • Days 3-4: 50% old formula, 50% new formula.
  • Days 5-6: 25% old formula, 75% new formula.
  • Day 7 and beyond: Switch to 100% new formula (Similac PRO Total Comfort).

Step 3: Monitor Your Baby During the transition period and after the full switch, closely monitor your baby’s reactions and behaviors. Look for any signs of discomfort, changes in bowel movements, or other unusual reactions. Keep an eye on their feeding patterns and general demeanor.

Cold Turkey Switching:

Here’s a step-by-step guide on how to switch cold turkey between these formulas:

  1. Single-Feed Transition: For a cold turkey switch, you’ll start with a single feeding. Here’s what to do:
    • Prepare the new formula according to the manufacturer’s instructions.
    • Replace one feeding with the new formula. This means if you are currently using Similac Total Comfort, you’ll give your baby Similac Pro Total Comfort for one feeding.
    • Continue to feed your baby the old formula for the remaining feedings during the day.
  2. Observe Your Baby: After the first feeding with the new formula, observe your baby closely for any adverse reactions or signs of digestive upset. Pay attention to their overall well-being, behavior, and any unusual changes in bowel movements or gas.
  3. Gradual Transition: Based on your baby’s response to the single feeding of the new formula, you can choose to either continue with the cold turkey switch or gradually increase the number of feedings with the new formula each day. If your baby tolerates the new formula well after the first feeding, you can increase the number of feedings with the new formula over the next few days.
  4. Continue Monitoring: Continue to monitor your baby’s reactions and well-being throughout the transition. Make sure there are no severe adverse effects like persistent fussiness, diarrhea, or feeding refusal.
  5. Complete the Switch: Once you are confident that your baby is tolerating the new formula well and there are no significant adverse effects, you can complete the switch and replace all feedings with the new formula.


In conclusion, Similac offers two popular formulas, Similac Total Comfort and Similac Pro Total Comfort, designed to address the needs of infants with sensitive tummies. Both formulas come from a trusted brand and share many similarities, including their age range, protein source, macronutrient composition, and added extras like OptiGro and prebiotics. Both formulas are also non-GMO and offer generic brand alternatives.

This Post Has One Comment

  1. Nina

    I agree with the moms.. ???????? Total comfort

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