Similac Pro Advance Vs All Similac Formulas: Full Comparison

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Similac Pro Advance is a standard milk-based formula designed for babies with no sensitivity to dairy products or lactose. The protein in this formula is nonfat milk with a ratio of whey to casein of 48:52 plus whey protein concentrate. In terms of carbohydrates, lactose is the only source with no added sugar. Furthermore, it has an extra feature called OptiGro which is a blend of DHA, lutein, and vitamin E for eye, brain, and cell development.

Moreover, most babies like the taste of Similac Pro Advance, but it may cause gas for some.

In this article, we will see a full comparison between Similac Pro Advance and all Similac formulas. Stay with me!

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Similac Pro Advance vs Similac Advance:

Similac Pro Advance vs Similac Advance

Similac Advance and Pro Advance are standard milk-based formulas using the same nutrient value and protein, carbs, and fat sources, they are similar. The only difference between them is the 2′-FL HMO prebiotic in the Pro Advance formula and the price; Similac Advance is cheaper than Pro Advance.

Moms Reviews:

Similac AdvanceSimilac Pro Advance
Positive
Reviews
Easy to mix
Great taste
Available in a ready-to-use
Cheaper
Good taste
Available in a ready-to-use
Negative
Reviews
It may cause spit up
it may cause gas
May cause gas

Can You Switch Between Similac Advance and Pro Advance?

Yes, your baby can take Similac Advance and Pro Advance interchangeably because they are of the same type (standard milk-based formula) and have the same nutrient, vitamin, and mineral values. Thus, not finding Similac Pro Advance in stores is not a problem, instead, you can switch to Similac Advance.

The table below shows a full comparison between those formulas:

Similac AdvanceSimilac Pro Advance
Protein sourceNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio48:5248:52
Carbohydrate source 100% Lactose100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOptiGro
PrebioticsShort-chain Fructooligosaccharides– 2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands9 Generic brands9 Generic brands
Protein (g)2.07 /100 Cal2.07 /100 Cal
Fat (g)5.6 /100 Cal5.6 /100 Cal
Carbohydrate (g)10.7 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal78 /100 Cal
Phosphorus (mg)42 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal
Sodium (mg)24 /100 Cal24 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium Sp. oilSchizochytrium Sp. oil
Size and Price12.4 oz
17.46 $
1.41/oz

30.8 oz
32.54 $
1.06 /oz


40 oz
39.78$
0.99 /oz

32 Fl Oz
7.82$
24.4 ¢/fl oz
30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
Rating4.7 of 5.0
1472 reviews
4.5 of 5.0
665 reviews
Ready-to-feedYesYes
Where to Buy?
Buy 12.4 oz HERE

Buy 30.8 oz HERE

Buy 40 oz HERE

Buy Ready-to-feed
Buy 30.8 oz HERE

Buy Ready-to-feed
Overall Note8/107.5/10
Similac Advance vs Similac Pro Advance

Similac Pro Advance vs Similac 360 Total Care:

Similac Pro Advance vs Similac 360 Total Care

Similac Pro Advance and Similac 360 Total Care are almost the same; they are standard milk-based formulas with nonfat milk protein and whey protein concentrate as protein sources and 100% lactose as a carbohydrate source. The only difference between them is that 360 Total Care has 5 HMO prebiotics whereas Pro Advance has 2 prebiotics plus the OptiGro feature which is a blend of DHA, lutein, and vitamin E for eye, brain, and cell development.

In terms of price, Similac Pro Advance powder is cheaper than 360 Total Care. However, the ready-to-feed version of the latter is cheaper.

Moms Reviews:

There aren’t many reviews about Similac 360 Total Care to make a definitive decision.

Can You Switch Between Similac Pro Advance and Similac 360 Total Care?

Yes, your baby can take Similac Advance and 360 Total Care interchangeably because they are of the same type (standard milk-based formula) and have the same nutrient, vitamin, and mineral values. Therefore, in case you didn’t find Similac Pro Advance in stores is not a problem now. Instead, buy the 360 Total Care formula, especially the ready-to-feed version as it’s cheaper.

The table below shows a complete comparison between Similac Pro Advance and 360 Total Care:

Similac Pro AdvanceSimilac 360 Total Care
Protein sourceNonfat Milk
Whey Protein Concentrate
Nonfat Milk
Whey Protein Concentrate
Whey to Casein Ratio48:52Not Found
Carbohydrate source100% Lactose100% Lactose
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGro5 HMO Prebiotics
Prebiotics– 2′-FL HMO
Short-chain Fructooligosaccharides
2′-FL HMO
Lacto-N-Tetraose
3-Fucosyllactose
6′-Sialyllactose
3′-Sialyllactose
Protein (g)2.07 /100 Cal2.07 /100 Cal
Fat (g)5.6 /100 Cal5.6 /100 Cal
Carbohydrate (g)10.7 /100 Cal10.5 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal78 /100 Cal
Phosphorus (mg)42 /100 Cal42 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal
Sodium (mg)24 /100 Cal24 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oil
Size and Price30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
20.6 oz
35.99 $
1.75 /oz

30.8 oz
44.88$
1.46 /oz

32-fl-oz
9.82$
30.7 ¢/fl oz
Ready-to-use versionYesYes
Rating4.5 of 5.0
665 reviews
4.8 of 5.0
197 reviews
Where to Buy?
Buy 30.8 oz HERE

Buy Ready-to-feed

Buy 20.6 oz HERE

Buy 30.8 oz HERE

Buy Ready-to-use
Overall Note7.5/107.5/10
Similac Pro Advance vs Similac 360 Total Care

Similac Pro Advance vs Similac Sensitive vs Similac Pro Sensitive:

Similac Pro Advance vs Similac Sensitive vs Similac Pro Sensitive

There is a big difference between Similac Pro Advance, Sensitive, and Pro Sensitive as they have different purposes. Similac Sensitive and Pro Sensitive are milk-based formulas and as their names show they are designed to reduce gas, fussiness, and spit-up due to lactose sensitivity by reducing lactose percentage by 99% and enriching them with vitamins and minerals. In contrast, Pro Advance is a standard milk-based formula for babies with no health issues.

In terms of price, Similac Pro Advance and Similac Sensitive are cheaper in powder form. However, in the ready-to-feed version, Similac Sensitive and Pro Sensitive are cheaper.

Moms Reviews:

Similac Pro AdvanceSimilac SensitiveSimilac Pro Sensitive
Positive
Reviews
Good taste
Available in a ready-to-use
The powder is cheaper
Good for fussiness
Good taste
Good for reflux
Less Expensive
Good for fussiness
Easy to digest
Good taste
Negative
Reviews
May cause gas
Hard to find
Too much foam
May cause gas
Doesn’t mix well
May cause constipation
May cause gas
Too foamy

Can You Switch Between Similac Pro Advance, Sensitive, and Pro Sensitive?

In case your baby shows bad reactions to Similac Pro Advance due to lactose sensitivity, at this moment, switching to Similac Sensitive or Pro Sensitive will be a good decision as these formulas are lactose-reduced. However, if your baby is on Similac Sensitive or Pro Sensitive and shows allergic reactions then you should switch to a formula of the same type or more gentle (partially hydrolyzed formula, extensively hydrolyzed formula, or the amino acid formula).

The safe switching is being from a standard milk-based formula to another standard milk-based formula, to a more sensitive formula, and so on like the picture below shows:

Image source: Nestle Health Science

I have done a full comparison between those formulas in the table below:

Similac Pro AdvanceSimilac SensitiveSimilac Pro Sensitive
Protein sourceNonfat Milk
Whey Protein Concentrate
Milk Protein IsolateMilk Protein Isolate
Whey to Casein Ratio48:5218:8218:82
Carbohydrate source100% Lactose 1% Lactose
Corn Syrup
Sugar
 1% Lactose
Corn Syrup
Sugar
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA/ARA
Extra FeaturesOptiGroOptiGroOptiGro
Prebiotics– 2′-FL HMO
Short-chain Fructooligosaccharides
Short-chain Fructooligosaccharides– 2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands9 Generic brands7 Generic brands7 Generic brands
Protein (g)2.07 /100 Cal2.1 /100 Cal2.1 /100 Cal
Fat (g)5.6 /100 Cal5.4 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.7 /100 Cal10.9 /100 Cal10.9 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal84 /100 Cal84 /100 Cal
Phosphorus (mg)42 /100 Cal56 /100 Cal56 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal5 /100 Cal
Sodium (mg)24 /100 Cal30 /100 Cal30 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
12.5 oz
17.46 $
1.40/oz

34.9 oz
37.92 $
1.09 /oz


32 fl oz
7.82$
24.4 ¢/fl oz
29.8 oz
36.96 $
1.24 /oz

32 fl oz
8.12$
25.4 ¢/fl oz
Rating4.5 of 5.0
665 reviews
4.5 of 5.0
1482 reviews
4.3 of 5.0
895 reviews
Ready-to-feedYesYesYes
Where to Buy?Buy 30.8 oz HERE

Buy Ready-to-feed

Buy 12.5 oz HERE

Buy 34.9 oz HERE

Buy Ready-to-feed
Buy 29.8 oz HERE

Buy Ready-to-feed
Overall Note7.5/107.5/107.5/10
Similac Pro Sensitive vs Similac Pro Advance vs Similac Sensitive

Similac Pro Advance vs Similac Total Comfort vs Similac Pro Total Comfort:

Similac Pro Advance vs Similac Total Comfort vs Similac Pro Total Comfort

The difference between Similac Pro Advance, Total Comfort, and Pro Total Comfort is that these late are partially hydrolyzed and lactose-reduced formulas whereas Similac Pro Advance is a standard milk-based formula for babies with no health issues. Furthermore, Pro Advance is sugar-free and has 48% whey plus 52% casein as components of nonfat milk. In contrast, Total Comfort and Pro Total Comfort contain sugar and the protein is 100% whey.

Moms Reviews:

Similac Pro AdvanceSimilac Total ComfortSimilac Pro Total Comfort
Positive
Reviews
Good taste
Available in a ready-to-use
Cheaper
Good for gas
Good taste
Good taste
Easy to digest
Available in a ready-to-use
Negative
Reviews
May cause gas
Hard to find
Hard to mixHard to mix
Spit up
Bad gas pain

Can You Switch Between Similac Pro Advance, Total Comfort, and Pro Total Comfort?

You can switch from Pro Advance to Total Comfort and Pro Total Comfort in case your baby has allergic responses to standard milk-based formulas because the protein in these late formulas is gentle to your baby’s tummy plus the 1% of lactose. However, the opposite is not recommended unless your baby has recovered from lactose or intact cow’s milk sensitivity.

On the other hand, switching between Similac Total Comfort and Pro Total Comfort is safe because they are almost the same.

The table below shows a full comparison between Similac Pro Advance, Total Comfort, and Pro Total Comfort:

Similac Pro AdvanceSimilac Total ComfortSimilac Pro Total Comfort
Protein sourceNonfat Milk
Whey Protein Concentrate
Partially hydrolyzed whey
protein
Partially hydrolyzed whey
protein
Whey to Casein Ratio48:52100% whey100% whey
Carbohydrate source100% Lactose1% Lactose
Corn Maltodextrin
Sugar
1% Lactose
Corn Maltodextrin
Sugar
Fat source– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
– High Oleic Safflower Oil
– Soy Oil
– Coconut Oil
– DHA and ARA
Extra FeaturesOptiGroOptiGroOptiGro
Prebiotics– 2′-FL HMO
Short-chain Fructooligosaccharides
Short-chain Fructooligosaccharides2′-FL HMO
Short-chain Fructooligosaccharides
Generic Brands9 Generic brands6 Generic brands6 Generic brands
Protein (g)2.07 /100 Cal2.32 /100 Cal2.32 /100 Cal
Fat (g)5.6 /100 Cal5.4 /100 Cal5.4 /100 Cal
Carbohydrate (g)10.7 /100 Cal10.7 /100 Cal10.7 /100 Cal
Vitamin A (IU)300 /100 Cal300 /100 Cal300 /100 Cal
Vitamin D (IU)60 /100 Cal60 /100 Cal60 /100 Cal
Vitamin E (IU)1.5 /100 Cal1.5 /100 Cal1.5 /100 Cal
Vitamin C (mg)
(Ascorbic acid)
9 /100 Cal9 /100 Cal9 /100 Cal
Inositol (mg)24 /100 Cal24 /100 Cal24 /100 Cal
Calcium (mg)78 /100 Cal105 /100 Cal105 /100 Cal
Phosphorus (mg)42 /100 Cal75 /100 Cal75 /100 Cal
Iron (mg)1.8 /100 Cal1.8 /100 Cal1.8 /100 Cal
Zinc (mg)0.75 /100 Cal0.75 /100 Cal0.75 /100 Cal
Manganese (mcg)5 /100 Cal5 /100 Cal5 /100 Cal
Sodium (mg)24 /100 Cal44 /100 Cal44 /100 Cal
Source of ARAMortierella alpina oilMortierella alpina oilMortierella alpina oil
Source of DHASchizochytrium sp. oilCrypthecodinium cohnii oilCrypthecodinium cohnii oil
Size and Price30.8 oz
37.48 $
1.22 /oz

32-fl oz
10.42$
32.6 ¢/fl oz
12.6 oz
17.99 $
1.43/oz
22.5 oz
28.98 $
1.29 /oz

29.8 oz
36.96 $
1.24 /oz

32-fl-oz
11.30$
35.3 ¢/fl oz
Whose Cheaper?Cheaper
Rating4.5 of 5.0
665 reviews
4.5 of 5.0
311 reviews
4.1 of 5.0
950 reviews
Ready-to-feedYesNoYes
Where to Buy?Buy 30.8 oz HERE

Buy Ready-to-feed

Buy 12.6 oz HERE
Buy 22.5 oz HERE

Buy 29.8 oz HERE

Buy Ready-to-feed
Overall Note7.5/108/108/10
Similac Total Comfort vs Similac Pro Advance vs Similac Pro Total Comfort

Final Thoughts:

Of all these formulas, the best alternative to Pro Advance in the Similac brand is Similac 360 Total Care and Similac Advance because they are of the same type (standard milk-based formulas). In terms of price, Similac Advance is the cheapest one either in powder or ready-to-use form.

The other formulas could be alternatives to Pro Advance in case your baby has an allergy to lactose or the intact cow’s milk protein.

Credit :

Image by starline on Freepik

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