Similac Pro Advance is a standard milk-based formula designed for babies with no sensitivity to dairy products or lactose. The protein in this formula is nonfat milk with a ratio of whey to casein of 48:52 plus whey protein concentrate. In terms of carbohydrates, lactose is the only source with no added sugar. Furthermore, it has an extra feature called OptiGro which is a blend of DHA, lutein, and vitamin E for eye, brain, and cell development.
Moreover, most babies like the taste of Similac Pro Advance, but it may cause gas for some.
In this article, we will see a full comparison between Similac Pro Advance and all Similac formulas. Stay with me!
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Similac Pro Advance vs Similac Advance:

Similac Advance and Pro Advance are standard milk-based formulas, they have the same protein source (nonfat milk + whey protein concentrate) and carbohydrate source (100% lactose). Also, they have the same nutrient, vitamin, and minerals level.
The only difference between Similac Advance and Pro Advance is the 2′-FL HMO prebiotic in the Pro Advance formula and the price; Similac Advance is cheaper than Pro Advance. Other than that, they are the same.
Moms Reviews:

Ingredients Comparison:
Similac Advance and Pro Advance have the OptiGro feature which is a blend of DHA, Lutein, and Vitamin E. This blend helps promote eye health and brain development and supports the development of cells.
Furthermore, both formulas have a whey-to-casein ratio of 48:52 whereas the average ratio in breast milk is 70% to 30% and 80% to 20% in early lactation and 50% to 50% in late lactation. The difference between them is that whey protein is digested quickly contrary to casein.
Related: HiPP Combiotic VS Similac Advance & Pro Advance: Which One is The Best?

Moreover, Both formulas have 9 generic brands to choose from in case you didn’t find these formulas, I have written an article about the best 9 generic brands of Similac Advance and Pro Advance if you want to check.
Nutrition Comparison:

Price Comparison:
In terms of price, Similac Advance is cheaper than Pro Advance in the powder and RTF forms. If we did a quick math, you will save 1440 $ in a year on Similac Advance.
Similac Advance | Similac Pro Advance |
---|---|
12.4 oz 17.46 $ 1.41/oz 30.8 oz 32.54 $ 1.06 /oz 40 oz 39.78$ 0.99 /oz 32 Fl Oz 7.82$ 24.4 ¢/fl oz | 30.8 oz 37.48 $ 1.22 /oz 32-fl oz 10.42$ 32.6 ¢/fl oz |
4.7 of 5.0 1472 reviews | 4.5 of 5.0 665 reviews |
Buy 12.4 oz HERE Buy 30.8 oz HERE Buy 40 oz HERE Buy Ready-to-feed | Buy 30.8 oz HERE Buy Ready-to-feed |
Can You Switch Between Similac Advance and Pro Advance?
Yes, your baby can take Similac Advance and Pro Advance interchangeably because they are of the same type (standard milk-based formula) and have the same nutrient, vitamin, and mineral values. Thus, not finding Similac Pro Advance in stores is not a problem, instead, you can switch to Similac Advance.
Similac Pro Advance vs Similac 360 Total Care:

Similac Pro Advance and Similac 360 Total Care are almost the same; they are standard milk-based formulas with nonfat milk protein and whey protein concentrate as protein sources and 100% lactose as a carbohydrate source.
The only difference between them is that 360 Total Care has 5 HMO prebiotics whereas Pro Advance has 2 prebiotics plus the OptiGro feature which is a blend of DHA, lutein, and vitamin E for eye, brain, and cell development.
In terms of price, Similac Pro Advance powder is cheaper than 360 Total Care. However, the ready-to-feed version of the latter is cheaper.
Moms Reviews:
There aren’t many reviews about Similac 360 Total Care to make a definitive decision.
Ingredients Comparison:
Similac Pro Advance and 360 Total Care have the same ingredients except that the latter has 5 HMO prebiotics which is a plus.
« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

Nutrition Comparison:

Price Comparison:
Similac Pro Advance | Similac 360 Total Care |
---|---|
30.8 oz 37.48 $ 1.22 /oz 32-fl oz 10.42$ 32.6 ¢/fl oz | 20.6 oz 35.99 $ 1.75 /oz 30.8 oz 44.88$ 1.46 /oz 32-fl-oz 9.82$ 30.7 ¢/fl oz |
4.5 of 5.0 665 reviews | 4.8 of 5.0 197 reviews |
Buy 30.8 oz HERE Buy Ready-to-feed | Buy 20.6 oz HERE Buy 30.8 oz HERE Buy Ready-to-use |
Can You Switch Between Similac Pro Advance and Similac 360 Total Care?
Yes, your baby can take Similac Advance and 360 Total Care interchangeably because they are of the same type (standard milk-based formula) and have the same nutrient, vitamin, and mineral values. Therefore, in case you didn’t find Similac Pro Advance in stores is not a problem now. Instead, buy the 360 Total Care formula, especially the ready-to-feed version as it’s cheaper.
Similac Pro Advance vs Similac Total Comfort vs Similac Pro Total Comfort:

The difference between Similac Pro Advance, Total Comfort, and Pro Total Comfort is that these late are partially hydrolyzed and lactose-reduced formulas whereas Similac Pro Advance is a standard milk-based formula for babies with no health issues.
Furthermore, Pro Advance is sugar-free and has 48% whey plus 52% casein as components of nonfat milk. In contrast, Total Comfort and Pro Total Comfort contain sugar and the protein is 100% whey.
Moms Reviews:

Ingredients Comparison:

Related: The best 6 generic brands of Similac Total Comfort and Pro Total comfort
Price Comparison:

Price Comparison:
Similac Pro Advance | 30.8 oz 37.48 $ 1.22 /oz Buy 30.8 oz HERE 32-fl oz 10.42$ 32.6 ¢/fl oz Buy Ready-to-feed |
Similac Total Comfort | 12.6 oz 17.99 $ 1.43/oz Buy 12.6 oz HERE |
Similac Pro Total Comfort | 22.5 oz 28.98 $ 1.29 /oz Buy 22.5 oz HERE 29.8 oz 36.96 $ 1.24 /oz Buy 29.8 oz HERE 32-fl-oz 11.30$ 35.3 ¢/fl oz Buy Ready-to-feed |
Can You Switch Between Similac Pro Advance, Total Comfort, and Pro Total Comfort?
You can switch from Pro Advance to Total Comfort and Pro Total Comfort in case your baby has allergic responses to standard milk-based formulas because the protein in these late formulas is gentle to your baby’s tummy plus the 1% of lactose. However, the opposite is not recommended unless your baby has recovered from lactose or intact cow’s milk sensitivity.
On the other hand, switching between Similac Total Comfort and Pro Total Comfort is safe because they are almost the same.
Final Thoughts:
Of all these formulas, the best alternative to Pro Advance in the Similac brand is Similac 360 Total Care and Similac Advance because they are of the same type (standard milk-based formulas). In terms of price, Similac Advance is the cheapest one either in powder or ready-to-use form.
The other formulas could be alternatives to Pro Advance in case your baby has an allergy to lactose or the intact cow’s milk protein.
Credit :
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