Enfamil Neuropro Gentlease Vs Enfamil Formulas

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Enfamil Neuropro Gentlease is a partially hydrolyzed and lactose-reduced formula by 80% designed to reduce fussiness, gas, and spit-up due to lactose sensitivity. The protein in this formula is from nonfat milk (partially hydrolyzed) plus whey protein concentrate (a source of MFGM). Moreover, carbohydrate is a mix of 80% corn syrup solids + 20% lactose.

As extra features, it has the milk fat globule membrane (MFGM) to help brain development and the 2’FL HMO prebiotic to promote digestive health.

According to moms’ reviews, Neuropro Gentlease help reduce fussiness, gas, and reflux. However, its taste is not so pleasant and it doesn’t mix well.

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In this article, we will dive into a full comparison between Enfamil Neuropro Gentlease and all Enfamil formulas in terms of ingredients, nutrients, extra features, and price. Stay with me!!

Enfamil Neuropro Gentlease vs Enfamil Enspire:

Enfamil Neuropro Gentlease vs Enfamil Enspire

The difference between Enfamil Neuropro Gentlease and Enfamil Enspire is that the latter is a regular milk-based formula designed for babies who haven’t an allergy to lactose or intact cow’s milk made from nonfat milk plus whey protein concentrate,100% lactose and contains two prebiotics (PDX and GOS).

In contrast, Neuropro Gentlease help reduces fussiness, gas, and spit-up due to lactose sensitivity made from partially hydrolyzed nonfat milk plus whey protein concentrate, and it’s lactose-reduced by 80%. Also, it contains the 2′-FL HMO prebiotic to support digestive health.

Ingredients Comparison:

Enfamil Enspire has as protein sources nonfat milk and whey protein concentrate with a whey-to-casein ratio of 60:40. In terms of extra features, Enspire has MFGM, Lactoferrin, and Omega 3 DHA.

Furthermore, Enspire has triple prebiotics one of them is an HMO prebiotic that resembles that found in breast milk.

Nutrition Comparison:

Price Comparison:

In terms of price, Enfamil Neuropro Gentlease is way cheaper (1.44 $/oz) than Enfamil Enspire (1.95 $/oz), the overprice of Enspire is due to its triple-added features: Omega 3 DHA to support cognitive development, Lactoferrin to help the immune health, and MFGM for brain development.

Enfamil Neuropro
Gentlease
Enfamil Enspire
19.5 oz
27.98 $
1.44/oz


27.4 oz
38.36 $
1.40 /oz


35.2 oz
47.46 $
1.35 /oz

32 Fl Oz
9.64$
30.1 ¢/fl oz
20.5 oz
39.98 $
1.95 /oz

30 oz
56.97 $
1.90 /oz
4.6 of 5.0
3370 reviews
4.8 of 5.0
1693 reviews
Has RTFNo RTF
Buy 19.5 oz HERE

Buy 27.4 oz HERE

Buy 35.2 oz HERE

Buy Ready-to-use
Buy 20.5 oz HERE

Buy 30 oz HERE

Mom’s Reviews Comparison:

What to choose?

In case your baby has lactose intolerance, then Neuropro Gentlease will be a good formula to start with because it has a gentle protein that is partially hydrolyzed and contains less lactose than the standard formula. On the other hand, when a baby hasn’t negative reactions to lactose or intact cow’s milk then Enfamil Enspire will be a good choice.

Enfamil Neuropro Gentlease vs Enfamil Neuropro Sensitive:

Enfamil Neuropro Gentlease vs Enfamil Neuropro Sensitive

The difference between Enfamil Neuropro Gentlease and Enfamil Neuropro Sensitive is that the latter is designed to reduce fussiness due to lactose sensitivity by lowering the lactose to 1% so the immune system won’t elicit negative responses to lactose, the protein source is milk protein isolate with whey to casein ratio of 60:40 plus whey protein concentrate (a source of MFGM)*

In contrast, Neuropro Gentlease and as its name indicates has a gentle protein that is partially hydrolyzed plus whey protein concentrate (a source of MFGM) to reduce fussiness, gas, and spit-up. However, as a carbohydrate source, it has 20% lactose + 80% corn syrup solids.

Neuropro Gentlease has 6 generic brands to choose from whereas Neuropro Sensitive has 7 store brands, I wrote an article about the best generic brands of Similac Neuropro Sensitive and Neuropro Gentlease.

Both formulas have the 2′-FL (Fucosyl Lactose) prebiotic to help promote digestive health by being food for probiotics (good bacteria), this prebiotic is resembling the important prebiotic in breast milk (Human Milk Oligosaccharides, or HMOs) that’s why it’s called 2’FL HMO.

« HMOs are special prebiotics found naturally in a mother’s breast milk. They are the most abundant solid ingredient in breast milk after fat and carbohydrates. In breastfed babies, HMOs are scientifically shown to positively affect the microbiome. » says nutritionnews.Abbott

*MFGM is a milk fat globule membrane that protects against some infectious diseases and promotes brain development, it’s extracted from whey protein concentrate.

Mom’s Reviews Comparison:

Price Comparison:

In terms of price, Neuropro Gentlease is way cheaper than Neuropro Sensitive. However, the latter has good taste and shows better results regard to reflux and gas.

Enfamil Neuropro
Gentlease
Enfamil Neuropro
Sensitive
19.5 oz
27.98 $
1.44/oz


27.4 oz
38.36 $
1.40 /oz

35.2 oz
47.46 $
1.35 /oz

32 Fl Oz
9.64$
30.1 ¢/fl oz
19.5 oz
33.77 $
1.73 /oz
4.6 of 5.0
3370 reviews
4.8 of 5.0
621 reviews
Has RTFNo RTF
Buy 19.5 oz HERE

Buy 27.4 oz HERE

Buy 35.2 oz HERE

Buy Ready-to-use
Buy 19.5 oz HERE

The closest formula to Neuropro Gentlease is Enfamil Gentlease, I did a full comparison between them in this article if you want to check.

Can you switch between Neuropro Gentlease and Neuropro Sensitive?

Yes, you can switch between Neuropro Gentlease and Neuropro Sensitive because they are both designed for the same purpose. Although they have different lactose amounts and different protein sources, according to mom reviews, they are both good for gas and fussiness.

Enfamil Neuropro Gentlease vs Enfamil Reguline:

Enfamil Neuropro Gentlease vs Enfamil Reguline

The difference between Enfamil Neuropro Gentlease and Enfamil Reguline is that the latter is made to soften stools and helps with constipation thanks to the dual blend prebiotic (PDX and GOS) and low iron level (1.5 /100 Cal) whereas Neuropro Gentlease is made to reduce fussiness, gas, and spit-up caused by lactose sensitivity.

Neuropro Gentleas and Reguline are both using partially hydrolyzed nonfat milk plus whey protein concentrate as protein sources and have the same fat source as the table below shows.

However, they differ in the lactose percentage and prebiotics; Neuropro Gentlease is lactose-reduced by 80% and has the 2’FL HMO prebiotic while Reguline has two prebiotics to help soften stools by increasing fecal mass and water retention. Also, it’s lactose-reduced by 50%.

Furthermore, Enfamil Neuropro Gentlease has a high inositol level (24mg /100 Cal) than Enfamil Reguline (6mg /100 Cal) whereas the average level in breast milk during lactation is 22mg /100 Cal.

“Inositol is an essential nutrient required by human cells in culture for growth and survival. Inositol promotes maturation of several components of surfactant and may play a critical role in fetal and early neonatal life. A drop in inositol levels in infants with respiratory distress syndrome (RDS) can be a sign that their illness will be severe.”

Source: National Library of Medicine

Price Comparison:

In terms of price, Enfamil Neuropro Gentlease is cheaper (1.44 $/oz) than Enfamil Reguline (1.54 $/oz) and has a ready-to-feed whereas the latter doesn’t.

Enfamil Neuropro
Gentlease
Enfamil Reguline
19.5 oz
27.98 $
1.44/oz


27.4 oz
38.36 $
1.40 /oz

35.2 oz
47.46 $
1.35 /oz

32 Fl Oz
9.64$
30.1 ¢/fl oz
12.4 oz
18.72 $
1.51 /oz

19.5 oz
29.98 $
1.54/oz
4.6 of 5.0
3370 reviews
4.8 of 5.0
1020 reviews
Has RTFNo RTF
Buy 19.5 oz HERE

Buy 27.4 oz HERE

Buy 35.2 oz HERE

Buy Ready-to-use
Buy 12.4 oz HERE

Buy 19.5 oz HERE

Gerber brand has also lactose-reduced formulas, that’s why I did a full comparison between Neuropro Gentlease and all Gerber Good Start formulas if you want to check.

Mom’s Reviews Comparison:

Can you switch between Neuropro Gentlease and Enfamil Reguline?

These formulas have different purposes, thus switching is better to be for a must. In case your baby suffers from gas, fussiness, or spit-up then choose Neuropro Gentlease whereas Reguline is chosen for babies who have hard stools or constipation.

Final Thoughts:

Between all these formulas, the best alternative to Enfamil Neuropro Gentlease in the Enfamil brand is Enfamil Neuropro Sensitive and Enfamil Gentlease because they are lactose-reduced, thus they can help babies with a lactose sensitivity to recover from fussiness, gas, and spit-up.

In terms of price, Neuropro Gentlease is cheaper than Neuropro Sensitive. However, the latter shows better results and has good taste.

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